Famvir

Фамвир Drug photo

The description is actual on 06.11.2014

  • Latin name: Famvir
  • ATH code: J05AB09
  • Active ingredient: Famtsiklovir (Famciclovir)
  • Producer: Novartis Pharma (Switzerland)

Structure

Active agent of drug Famvir (Famvir) – famtsiklovir. Additional components: hydroxypropyl cellulose, starch sodium glycollate, lactose anhydrous, magnesium stearate.

The cover consists of a gipromelloza, polyethyleneglycol 4000, titanium of dioxide, polyethyleneglycol 6000.

Release form

Medicine is sold in tablets. In one packaging there can be 1-4 blisters. In one blister there can be from 3 to 10 tablets.

Pharmacological action

This medicine has antiviral effect.

Pharmacodynamics and pharmacokinetics

After oral administration active agent of drug will be transformed in pentsiklovir which makes impact on a cytomegalovirus, and also Epstein-Barre's virus and viruses of herpes of the person. It gets to the infected organism sites where turns into the monophosphate passing into triphosphate. Being in the infected cells more than 12 hours, it interferes with replication of virus DNA. Its contents in cells where there is no virus, minimum therefore triphosphate does not influence them.

Pentsiklovir acts in relation to steady against an acyclovir of virus strains of Herpes simplex with changed a DNA polymerase.

Drug reduces manifestation and duration of post-herpetic neuralgia at people with the surrounding herpes.

Its bioavailability – 77%. The maximum concentration of medicine is reached approximately 45 minutes later. Pentsiklovir is characterized by extent of communication with proteins of plasma less than for 20%. Time of semi-removal from plasma till 2 o'clock. Active agent of drug is removed mainly with urine.

Indications to use

This medicine is appointed by the doctor at:

  • to chicken pox;
  • supressivny therapy of the recurrent infection connected with herpes;
  • primary infection with a herpes simplex virus;
  • shingles;
  • to oftalmogerpesa;
  • viral infections because of Herpes simplex and Varicella zoster;
  • post-herpetic neuralgia;
  • exacerbation of the infections connected with herpes.

Contraindications

Drug cannot be used at:

  • special sensitivity to a pentsiklovir and components of medicine;
  • viral infectious diseases at children;
  • pregnancies;
  • breastfeeding.

Side effects

Side reactions when using drug appear seldom. Sometimes patients complain of a headache or nausea, but these manifestations are poorly expressed. Besides, the following possible collateral manifestations are known:

Application instruction of Famvir (Way and dosage)

The instruction on Famvir reports that a pill should be taken orally. Time of their reception does not depend on food, at the same time they cannot be chewed, but it is possible to wash down with water. Dosages depend on morbid condition and other factors.

At the infection provoked by the Varicella zoster virus (at the same time the patient has a normal immunity), recommend to accept 3 times during the day 250 mg, 2 times during the day on 500 mg or 1 time during the day on 750 mg. At post-herpetic neuralgia give 3 times during the day 250-500 mg. At an oftalmogerpesa appoint 3 times during the day 500 mg. At the infection provoked by the type Herpes simplex 1 and 2 virus (at the same time the patient has a reduced immunity), accept 2 times during the day 500 mg. The application instruction of Famvir reports that in all four cases the course of use is expected a week. It is desirable to begin therapy right after manifestation of the first symptoms of diseases.

At infections which are caused by the Varicella zoster virus patients with reduced immunity for 10 days are given 500 mg of medicine 3 times/days.

At the infections provoked by the type Herpes simplex 1 and 2 virus (at the same time the patient has a normal immunity), give 3 times/days on 250 mg. At recurrence of persistent infection to patients at adult age appoint medicine 2 times/days in a dosage of 125 mg. In both cases it is desirable to begin therapy at the first symptoms of a disease, medicine is applied for five days.

In case of a recurrent herpes infection accept 2 times/days on 250 mg. The course of therapy is appointed individually in each case depending on weight of a course of a disease.

For the purpose of an assessment of possible changes it is recommended to stop once a year use of tablets.

Effective dosage for HIV-positive patients, as a rule, 2 times/days on 500 mg.

Day doses according to KK (ml/min. / 1.73 sq.m) can be the following:

The infections provoked by the Varicella zoster virus at KK indicators:

  • it is more or equal 40 – 3 times on 250/500 mg;
  • from 30 to 39 - 2 or 3 times on 250 mg;
  • from 10 to 29 - 2 or 3 times on 125 mg.

The infections provoked by the Herpes simplex virus (at the same time the patient has a reduced immunity), at KK indicators:

  • it is more or equal 40 – 2 times on 500 mg;
  • from 30 to 39 - 2 times on 250 mg;
  • from 10 to 29 - 2 times on 125 mg.

The infections provoked by the Herpes simplex virus (at the same time the patient has a normal immunity):

  • the first episode – indicators of KK is more or 30 – 3 times on 250 mg are equal; indicators of KK from 10 to 29 – 3 times on 125 mg;
  • the recurrent infection – indicators of KK is more or 10 – 3 times on 125 mg are equal.

Supressivny therapy of a recurrent herpes infection, at KK indicators:

  • it is more or equal 30 – 2 times on 250 mg;
  • from 10 to 29 - 2 times on 125 mg.

People with a renal failure who are on a hemodialysis need to take medicine right after a hemodialysis. Reception of 125 mg at genital herpes is recommended and 250 mg at the surrounding herpes.

Overdose

At the raised dosage in case of a chronic renal failure the acute renal failure can develop.

In case of overdose the symptomatic and supporting treatment is carried out. Active agent of drug can be removed by means of a hemodialysis. At the same time the maintenance of a famtsiklovir decreases by 75% within four hours.

Interaction

Clinically significant interaction of Famtsiklovir with other drugs is not noted. Drugs which block canalicular secretion can increase plasma concentration of a pentsiklovir.

Terms of sale

Is on sale according to the recipe of the specialist.

Storage conditions

Optimum temperature is up to 30 °C. Medicine needs to be stored in the place unavailable to small children.

Period of validity

Three years.

Famvir's analogs

Famvir's analogs in drugstores it is possible to get the following:

The last drug is often appointed if it is necessary to replace Famvir.

The price of analogs can be different. The majority of them are cheaper than Famvir so many patients give preference to these means.

What it is better — Valtreks or Famvir?

Quite often on consultation people ask the doctor that Valtreks or Famvir is better. Specialists do not give a definite answer. Actually, effect of both drugs is similar. Nevertheless, Famvir's cost is higher. So patients who want to save often choose Valtreks as its price much less.

About Famvire

About Famvire it is possible to meet different. Someone enthusiastically tells about how this means helped it, however also cases when the rate of drug was ineffectual are not rare. Besides, some About Famvire report about side reactions in the form of an allergy.

Zdravzona

  • Famvir of 250 mg No. 21 tabletkinovartis Farm
  • Famvir of 125 mg No. 10 tabletkinovartis Farm
  • Famvir of 500 mg No. 3 tabletkinovartis Farm

Drugstore of IFC

  • Famvir tbl p / about 500 mg No. 3, Novartis Farmaceutica S.A.Ispaniya
  • Famvir tbl p / about 250 mg No. 21, Novartis Pharma S.A.S.Frantion
  • Famvir tbl p / about 125 mg No. 10, Novartis Pharma S.A.S.Frantion
to show still

Apteka24

  • Famvir14
  • Famvirnovartis Pharmaceutica (Spain)
  • Famvirnovartis Pharmaceutica (Spain)

Paniapteka

  • Famvir of the tab. of 250 mg of N21novartis
  • Famvir of the tab. of 250 mg of N21novartis
  • Famvir of the tab. of 250 mg of N21novartis
Section: Antiviral
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Famvir surely consult with the attending physician.