Финоптин Drug photo

The description is actual on 02.07.2016

  • Latin name: Finoptin
  • ATH code: C08DA01
  • Active ingredient: Verapamil (Verapamil)
  • Producer: Orion Corporation/Orion Pharma (Finland)


In 1 tablet of verapamil of a hydrochloride of 40 or 80 mg. MKTs, lactose monohydrate, silicon dioxide, gelatin, magnesium stearate as excipients.

Release form

Tablets in a cover of 40 mg and 80 mg.

Pharmacological action

Antiarrhytmic, anti-anginal, hypotensive.

Pharmacodynamics and pharmacokinetics


Blocker of calcium channels. Has antiarrhytmic, anti-anginal and hypotensive effect. The mechanism of action is connected with braking of transport of calcium ions in a cell that attracts reduction of contractility of a myocardium. Considerably slows down conductivity on AV connection, automatism of a sinus node oppresses. Has vasodilating, hypotensive effect. Reduces contractility of a myocardium and reduces Chss.Antianginalny effect of drug is explained by decrease in a tone of peripheral vessels and OPSS, expansion of coronary vessels and increase in a coronary blood-groove.

At verapamil influence on the carrying-out system of heart — a sinus and atrioventricular node therefore it is effective only at supraventricular arrhythmias is more expressed. Action on vessels is expressed much more weakly. It is applied at treatment of vasospastic stenocardia and stenocardia with supraventricular disturbances of a rhythm. Action is shown in 1-2 hours, and the maximum action is reached in two days after an initiation of treatment.


At intake more than 90% of a dose are soaked up. The maximum concentration in plasma is defined in 1-2 hours. Meal does not reduce absorbability. It is actively metabolized, and one of metabolites has the concentration exceeding concentration of verapamil. Accumulation in an organism of active ingredient and metabolites explains action strengthening.

Contacts blood proteins for 90%. The t of ½ from 2 to 8 hours, at repeated receptions is extended till 5-12 o'clock. 70% are brought by kidneys and 25% with bile. At liver diseases bioavailability increases, the clearance decreases and the elimination half-life increases. At diseases of kidneys insignificant are defined or there are no changes of kinetics. At elderly persons the clearance decreases, and concentration in plasma increases.

Indications to use


  • The expressed bradycardia;
  • heart failure;
  • sinoauricular block;
  • cardiogenic shock;
  • arterial hypotension;
  • AV blockade of the II-III degree;
  • age till 18 flyings.

With care it is appointed at AV blockade of the I degree, a hypertrophic subaortal stenosis, at elderly people.

Side effects

The met side reactions are more often:

  • nausea, vomiting;
  • lock (diarrhea is more rare);
  • appetite increase;
  • dizziness;
  • hyperemia of the person;
  • uneasiness, depression;
  • drowsiness;
  • increased fatigue;
  • adynamy;
  • increase in weight;
  • increase of activity of transaminases of a liver;
  • skin itch, rash;
  • peripheral hypostases.

Seldom met side reactions:

  • stenocardia;
  • the expressed bradycardia;
  • hypotension;
  • atrioventricular block;
  • aggravation of heart failure at reception of high doses;
  • agranulocytosis, thrombocytopenia;
  • galactorrhoea;
  • gynecomastia;
  • arthritis;
  • decrease in fertility at men.

Finoptinum, application instruction (Way and dosage)

Pill is taken inside after food, them follows entirely, without chewing. Daily dose no more than 480 mg.

At stenocardia treatment is begun with 40-80 mg three times a day. Then the dose increases to achievement of effect and can reach 240-480 mg a day, for 3-4 receptions. At arterial hypertension take 40-80 mg 3 times a day, in certain cases to 480 mg a day for 3 receptions. In such cases it is more reasonable to use Finoptinum of 80 mg.

For prevention of supraventricular tachycardia appoint 240-480 mg a day for 4 receptions. During the trembling or atrial fibrillation — 240-320 mg a day for 3 receptions. The antiarrhytmic effect is noted in two days from an initiation of treatment in such dosages. Elderly people need reduction of a dosage. At the expressed insufficiency it is appointed 1/3 from a daily dose. It is impossible to stop suddenly treatment by drug.


Overdose is observed when exceeding a dose at 5-10 times by confusion of consciousness, nausea, vomiting, bradycardia, an atrioventricular block, spasms, a metabolic acidosis, a collapse and an asystolia. Treatment is begun with a gastric lavage and reception of absorbent carbon. At conductivity disturbance — intravenously atropine, calcium a gluconate, plasma substituting solutions. At hypotension Phenylephrinum. The hemodialysis is not effective.


Verapamil raises Cmax of cyclosporine, Glibenclamidum, a sirolimus and a takrolimus, Buspiron and midazolam, theophylline, ethanol, quinidine, a simvastatin and an atorvastatin, an almotriptan, cardiac glycosides, a metoprolol and propranolol, colchicine, doxorubicine, Prazozinum and a terazozin. Strengthens effect of peripheral muscle relaxants.

Increases concentration of verapamil in blood a concomitant use of erythromycin, a ritonavir, a telitromitsin, reception of grapefruit juice.

Cimetidinum increases bioavailability of drug by 50%, and rifampicin considerably reduces it.
Phenobarbital increases clearance by 5 times, and Sulfinpyrazonum by 3 times.

At simultaneous use of inhalation anesthetics the risk of bradycardia and an atrioventricular block is high. Increase in risk of bradycardia and disturbances of AV of conductivity is observed at a combination with beta adrenoblockers. Alpha adrenoblockers, diuretics, APF inhibitors, vazodilatator strengthen hypotensive effect.

Drugs of lithium and carbamazepine increase risk of a neurotoxicity. At use with acetylsalicylic acid the bleeding time increases.

Terms of sale

According to the recipe.

Storage conditions

Temperature of storage is up to 25 °C.

Period of validity

5 years.


Coincidence on the ATH code of the 4th level:

Verogalid, Verapamil, Likoptin, Isoptinum, Kaveril.

About Finoptinum

 At arrhythmia carry Finoptinum which is appointed at supraventricular arrhythmias (a ciliary arrhythmia and a Bouveret's disease) to number of often used drugs. Its use at stenocardia is also shown.

In responses of patients it has reflection:

  • "… I have a stenocardia with frequent attacks, after a hospital accept Finoptinum. It helps to prevent attacks";
  • "… At sinus tachycardia the cardiologist recommended to drink this drug constantly";
  • "… Extrasystoles sometimes whole day. The cardiologist recommends constantly it to drink".

Rather often this drug is appointed in parallel with Ginipral who causes tachycardia, at threat of an abortion or premature births: "… About 22 weeks drank Finoptinum + giniprat — there was a threat of premature births. Transferred well, pregnancy informed".

At stenocardia it reduced myocardium ischemia that was registered on an ECG. At patients at reception of this drug portability of an exercise stress considerably increased, but the effect came at reception of 160-240 mg a day. Such dose was reached gradually under pulse control. Recently the group of drugs of verapamil is forced out by generation drugs II which use is more reasonable in cardiological practice as they have higher performance, it is less than side effects and can be appointed  once a day.


  • Finoptinum of 80 mg No. 30 of a tablet
  • Finoptinum of 40 mg No. 30 of a tablet
  • Finoptinum of 40 mg No. 100 of a tablet
  • Finoptinum of 80 mg No. 100 of a tablet
to show still


  • Finoptinum of a tablet 40 of mg No. 30 Orion (Finland)
  • Finoptinorion (Finland)
  • Finoptinorion (Finland)


  • Finoptinum of the tab. of 40 mg No. 100
Section: Cardiological Cardiovascular
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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