Flamaks

Фламакс Drug photo

The description is actual on 23.07.2014

  • Latin name: Flamax
  • ATH code: M01AE03
  • Active ingredient: Ketoprofen (Ketoprofen)
  • Producer: Soteks Farmfirma (Russia)

Structure

Flamaks capsules (1 capsule) contain in structure the operating ingredient ketoprofen (50 mg), and also additional substances: MKTs, lactoses monohydrate, sodium lauryl sulfate, croscarmellose sodium, silicon dioxide colloid, povidone.

Flamaks Forte tablets contain 100 mg of active ingredient ketoprofen (1 tablet), and also additional ingredients: rice starch, lactoses monohydrate, croscarmellose sodium, silicon dioxide colloid, MKTs, povidone, sodium lauryl sulfate, macrogoal 6000, magnesium stearate, gipromelloz, talc, titanium dioxide.

Flamaks in the form of solution contains 100 mg of ketoprofen in one ampoule (2 ml). Also additional substances propylene glycol, benzyl alcohol, ethanol, sodium hydroxide, water for injections are a part.

Release form

Flamaks (Flamax) is issued in the form of capsules, solution for introduction intravenously and intramusculary, rectal suppositories, lyophilisate for the subsequent preparation of solution, tablets, capsules.

Capsules of Flamaks have a white body and a blue lid, white powder which has a homogeneous consistence contains inside.

Solution contains in ampoules on 2 ml having a color ring of a break or a notch. Strip planimetric packaging contains 5 ampoules.

Flamaks Forte is issued in the form of biconvex round tablets of blue color which are covered with a film cover. The blister contains 10 tablets, in a cardboard pack 2 blisters are located.

Capsules of Flamaks forte contain in the container from plastic which is placed in a pack from a cardboard.

Pharmacological action

Drug renders anti-aggregation, analgeziruyushchy, antiinflammatory, febrifugal impact on an organism. The analgesic effect is caused by both the central, and peripheral mechanisms.

Pharmacodynamics and pharmacokinetics

Ketoprofen contacts blood proteins in an organism for 99%, generally albumine. The greatest concentration of substance in plasma is reached rather quickly. Ketoprofen quickly gets to connecting fabrics and synovial fluid. In 15 minutes after one-time administration of drug high concentration of active agent in synovial fluid is intramusculary noted. It remains till 30 o'clock therefore it is possible to reduce pain and constraint in joints by a long span. Through GEB in essential quantities does not get.

The metabolism of ketoprofen occurs generally in a liver. There takes place process of a glyukuronirovaniye after which esters and glucuronic acid are formed. Further they are brought by kidneys. The elimination half-life of ketoprofen makes from 1,6 to 1,9 h.

Indications to use

Medicine of Flamaks and Flamaks is Forte applied for the purpose of symptomatic therapy of pains and inflammatory processes of a different origin at their moderate intensity:

  • diseases of a musculoskeletal system of the person (arthritis, rheumatic defeat of soft tissues, ankylosing spondylitis, osteoarthrosis);
  • sciatica, neuralgia, lumbago;
  • migraine, pain after operation;
  • painful periods, inflammatory processes in bodies of a small pelvis;
  • pain and inflammatory processes after traumatized;
  • dentagra;
  • pain at onkoboleznyakh.

Contraindications

Flamaks (Flamax) it is not applied in the following cases:

  • high sensitivity;
  • period of an exacerbation of ulcers and erosion of a gastrointestinal tract;
  • exacerbation of inflammatory diseases of intestines;
  • bleedings from a gastrointestinal tract;
  • acute period of diseases of kidneys, severe form of a liver failure.
  • hyperpotassemia;
  • the progressing diseases of kidneys;
  • combination of the nose recuring a polypose or bronchial asthma with intolerance of NPVS, in particular acetylsalicylic acid;
  • disturbances of a hemostasis, hemopoiesis;
  • after aortocoronary shunting;
  • third trimester of pregnancy and chest feeding;
  • age of the patient till 15 flyings.

Carefully medicine is applied at arterial hypertension, bronchial asthma, hypostases, chronic heart failure, sepsis, a diabetes mellitus, a renal failure, an ischemic heart disease, serious somatic illnesses.

Side effects

Emergence of such side effects is possible:

  • Alimentary system: dyspepsia, abdominal pain, change of flavoring feelings, disturbances of functions of a liver, stomatitis, taste change. At long treatment by high doses of HP bleeding of a gastrointestinal tract, gums, and also emergence of ulcers on mucous a gastrointestinal tract is possible.
  • Nervous system: sleeplessness, headache, nervousness, dizziness, migraine, manifestations of drowsiness or hyperexcitability, memory impairment.
  • Sense bodys: deterioration in sight, a ring in ears, pain and dryness in eyes, deterioration in hearing, a conjunctiva hyperemia.
  • Cardiovascular system: tachycardia, increase of the ABP.
  • Bodies of a hemopoiesis: anemia, agranulocytosis, leukopenia, thrombocytopenia.
  • Urinary system: cystitis, an urethritis, disturbances in work of kidneys, nephrite, a hamaturia.
  • Allergic manifestations: rash, itch of integuments, hypostases, rhinitis, bronchospasm, dermatitis.
  • Other manifestations: pneumorrhagia, strong sweating, twitching of muscles, asthma, mialgiya, nasal bleeding. At treatment by high doses of drug perhaps vaginal bleeding.

Application instruction of Flamaks (Way and dosage)

If the patient begins treatment with drug of Flamaks, the application instruction has to them be carefully studied.

Pricks (solution) are entered intravenously and intramusculary. Intravenous administration is carried out only in a hospital. On average infusion continues 0,5–1 h, at most – 48 hours. The medicine dose at the same time should not be higher than 300 mg. At short infusion of 100-200 mg of means gets divorced in 100 ml of 0,9% of solution of sodium chloride, introduction continues no more than 1 hour. The following time the drug can be administered after 8 hours. At long infusion of 100-200 mg of means gets divorced in 500 ml of solution for infusions, introduction continues 8 hours. The following time it is possible to administer the drug in 8 hours.

Intramusculary Flamaks is entered on 100 mg 1–2 times a day.

Capsules of Flamaks need to be accepted inside, in the course of reception of food. The dosage is appointed by the doctor depending on disease. The maximum dose of means in days — 300 mg.

The application instruction of Flamaks Forte provides that a pill should be taken orally in the course of reception of food. As a rule, reception of 1 tablet 2–3 times a day is appointed. An admissible daily dose — 300 mg.

Overdose

Overdose of means is not dangerous. At the same time dizziness, a headache, vomiting, abdominal pains, short wind, bleedings and other side effects can be shown.

The symptomatic treatment, in particular, a gastric lavage, reception of sorbents is necessary. The specific antidote is absent.

Interaction

At treatment by any other drugs together with Flamaks it is necessary to consult surely before therapy with the doctor.

If Flamaks and loopback diuretics is at the same time appointed, nephrotoxic influence of these drugs amplifies. Flamaks reduces efficiency of uricosuric drugs, but strengthens influence of anticoagulants, ethanol, fibrinolitik, antiagregant, and also manifestation of by-effects at reception of GKS and mineralokortikosteroid, estrogen.

Flamaks reduces efficiency of influence of antihypertensives and diuretics.

At simultaneous use with GKS, other NPVS, corticotropin, ethanol display of bleedings of a gastrointestinal tract, ulcers, disturbances of functions of kidneys is possible.

The risk of developing of bleedings increases at a concomitant use with heparin, anticoagulants, trombolitika, antiagregant, tsefoperazony, tsefamandoly, tsefotetany.

At treatment by Flamaks it is necessary to carry out recalculation of doses of insulin and other hypoglycemic drugs as their hypoglycemic action increases.

Simultaneous treatment with reception of Valproatum of sodium leads to decrease in aggregation of thrombocytes.

Increases concentration of nifedipine, verapamil, drugs of lithium, a methotrexate in a blood plasma.

Raises a gematotoksichnost of miyelotoksichny means.

Absorption of drug decreases at a concomitant use of Colestyraminum and antacids.

When mixing rolled into one Tramadola and Flamaks is formed a deposit.

Terms of sale

Flamaks and Flamaks are Forte implemented to the recipe of the doctor.

Storage conditions

It is necessary to store Flamaks in the dark and dry place, temperature at the same time should not exceed 25 °C. Means needs to be protected from children.

Period of validity

It is possible to store HP 3 years.

Special instructions

If treatment is at the same time carried out by means of Flamaks and Warfarin or drugs of lithium, strict control from the attending physician is necessary.

Flamaks can mask symptoms of infectious diseases.

In the course of therapy it is important to control indicators of peripheral blood, and also activity of a liver, kidneys. If their functions are broken, it is necessary to lower a dose and to conduct careful supervision over the patient.

To reduce probability of development of by-effects from a gastrointestinal tract, it is necessary to use the minimum doses drug and not to practice prolonged treatment.

If definition of 17 ketosteroids is necessary, Flamaks is cancelled in 48 hours prior to carrying out research.

It is important to consider that at treatment by means concentration of attention therefore it is necessary to drive carefully transport can worsen and to perform other potentially dangerous works.

Analogs

Analogs of Flamaks and Flamaks Forte which are implemented in drugstores it is drugs Ketonal, Fleksen, Artrozilen, Ketosprey, Ketonal uno, Arketal, Artrum, Profenid , etc.

All analogs have the same action on an organism, as well as Flamaks, but drug only the doctor has to make the decision on the final choice.

Zdravzona

  • Flamaks 50 mg No. 25 kapsulyreplek Pharm Ltd
  • Flamaks forte 100 mg No. 20 tabletkireplek Pharm Ltd
  • Flamaks solution for injections 50mg/ml 2 ml No. 5 ampulysoteks Farmfirma of closed joint stock company
  • Flamaks solution for injections 50mg/ml 2 ml No. 10 ampulysoteks Farmfirma of closed joint stock company

Drugstore of IFC

  • Flamaks Forte tbl p/pl/o 100 mg No. 20 **, Soteks Zaorossiya Replekpharm AD/
  • Flamaks kaps 50 mg No. 25, Replekpharm AD/of Soteks Zaorossiya
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Section: Anesthetics
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Education: "Pharmacy" graduated from the Rovno state basic medical college majoring in. Graduated from the Vinnytsia state medical university of M. I. Pirogov and internship on its base.

Experience: From 2003 to 2013 – worked at positions of the pharmacist and manager of a pharmaceutical booth. It is awarded by diplomas and distinctions for long-term and honest work. Articles on medical subject were published in local editions (newspaper) and on various Internet portals.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before use of medicine of Flamaks surely consult with the attending physician.