Flebodia 600

Флебодиа 600 Drug photo

The description is actual on 04.07.2014

  • Latin name: Flebodia 600
  • ATH code: C05CA03
  • Active ingredient: Diosmin (Diosmin)
  • Producer: Innothera Chouzy (France)

Structure

The granulated diosmin (the main active agent of drug) which corresponds to the cleared anhydrous – 600 mg.

Auxiliary components:

  • talc;
  • colloid silicon dioxide;
  • stearic acid;
  • microcrystallic cellulose;
  • mix of dyes – the red cochineal insect (ponso 4R), titanium dioxide, propylene glycol, red and black iron oxide;
  • opaglos 6000 – palm and beeswax, gummilak, 95 percent ethanol.

The protective covering film consists from:

  • gipromelloza;
  • microcrystallic cellulose;
  • polyethylene glycol stearate 400.

Release form

The biconvex tablets of a round form covered with a pink cover (a protective film like Sepifilm 002). On a section look as a gray-brown kernel with a surrounding light cloak. About 15 pieces in the blister, a cardboard box one or two blister strip packagings are packed up.

Pharmacological action

The main effects of medicine are directed to a venous bed:

  • reduces distensibility of veins;
  • tones up a vascular wall;
  • strengthens a wall of capillaries, considerably preventing a possibility of their damage;
  • to some extent relieves of venous stagnation;
  • increases resistance of a microcirculator bed;
  • reduces permeability of venous capillaries.

The Flebotoniziruyushchy effect of active component is dozozavisimy, that is manifestations of biological effect in direct ratio to amount of the accepted medicine.

Flebodia influences also nalimfatichesky vessels – considerably increases the frequency of reductions of capillaries, thereby increasing their functional capacity (a vozrastayetlimfatichesky drainage), reduces lymphatic pressure, expands density of a vascular bed.

Drug improves blood supply of skin as promotes the facilitated diffusion of oxygen and perfusion in epidermal covers, influences in a stimulating way a microcirculator bed.

Separately it should be noted that Flebodia influences active components of the biological nature:

  • strengthens vasoconstrictive effects of adrenaline, noradrenaline;
  • interferes with allocation of free radical elements, prostaglandins and thromboxanes;
  • reduces adhesion of leukocytes to walls of a venous bed;
  • reduces quantity free superoxide-anions;
  • reduces redistribution migration of white blood cells in paravenous fabrics.

Pharmacodynamics and pharmacokinetics

Tablets of Flebodia are quickly adsorbed from a digestive tract (are accepted orally). It is found in plasma after two hours, and the maximum concentration of drug in blood is noted in five hours after medicine use.

Diosmin is evenly deposited, both in venas cava, and in an underfoot vascular bed of the lower extremities or in other fabrics. Active components mainly by means of kidneys (about 80 percent of a one-time dosage), to a lesser extent with a stake (about 11 percent) and bile (2.4 percent) are removed.

Indications to use

Contraindications

  • intolerance, hereditary idiosyncrasy or individual hypersensitivity to compound components of medicine;
  • the period of a lactation and chest feeding for young mothers;
  • the age category is younger than 18 years.

Side effects

Medicine of Flebodia is, as a rule, transferred well, rendering the maximum therapeutic effect without collateral influences. However in clinical practice of some qualified specialists such undesirable reactions as are described:

Such side effects do not demand treatment and pass independently after a short break in conservative therapy.

Application instruction of Flebodia 600 (Way and dosage)

Tablets are used orally, regardless of meal, physical activity and the periods of wakefulness. The scheme of therapy is appointed by individually attending physician or the qualified druggist, however usually it passes by one of three most tested techniques.

If medicine is used at a lecheniivarikozny phlebectasia of ilikhronichesky insufficiency of a venous bed of the lower extremities, then the daily dosage of drug makes 1 tablet a day. The course depends on a pathophysiological stage of a disease: the initial stages of development demand administration of drug within two months, and later – three-four months. In the presence of trophic changes of an integument (necrotic ulcers as extreme extent of development of pathology) the course is prolonged before half a year. Will repeat, treatment can each two-three months.

600 at an aggravation of a hemorrhoidal inflammation of venous cavities of a rectum it is much easier to remember the instruction to Flebodia. About 2-3 tablets per day within a week for stopping of an acute state are appointed. Further, if necessary, the course is prolonged one tablet a day for two-three months.

During the second and third trimester of pregnancy medicine helps to get rid of chronic limfovenozny insufficiency if to accept on 1 tablet of times a day. It is recommended to take a therapeutic course under supervision of qualified specialists, that is pristatsionarny treatment. It is necessary to stop sanitation in two-three weeks prior to childbirth what the attending physician has to report about.

Overdose

Symptoms of the increased concentration of drug in a blood plasma are not registered.

Interaction

Significant effects at combined use of medicines with tablets of Flebodia are not described.

Terms of sale

Drug is in free sale, that is in pharmaceutical booths is released without presentation of the prescription form.

Storage conditions

It is necessary to store tablets in the dry place unavailable to children of a younger age category, at the room temperature to 27 degrees Celsius. It is impossible to leave medicine under the influence of straight lines or the reflected sunshine.

Period of validity

2 years.

Special instructions

At therapy of acute hemorrhoidal crisis it is necessary to be observed at the proctologist and to conduct regular additional researches as drug can have the pharmaceutical effect not at once that is fraught with an aggravation of symptoms and a progression of pathological process up to loss of the inflamed venous cavities of a rectum. In case of absence of fast effect therapy is supplemented specialized medicinal sredstvamigemodinamichesky itoniziruyushchy action.

Synonyms

Detralex, Diosmin.

Zdravzona

  • Flebodia of 600 600 mg No. 15 tabletkiinnothera Chouzy
  • Flebodia of 600 600 mg No. 30 tabletkiinnothera Chouzy
  • Flebodia of 600 600 mg No. 60 tabletkiinnothera Chouzy
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BIOSPHERE

  • Flebodia of 600 mg No. 30 of table.
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Section: Cardiovascular
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Education: Kharkiv national medical university

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