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Floksal
Structure
- Floksal 0,3% contain eye drops in 1 ml of an ofloksatsin – 3 mg. Excipients: chloride benzalkoniya, acid solution hydrochloric, sodium chloride, sodium hydroxide solution, water.
- The oculentum Floksal of 0,3% contains ofloxacin in number of 3 mg in 1 gram. Excipients: liquid paraffin; wool fat; white vaseline.
Release form
Drops for eyes represent transparent solution of pale yellow color. 5 ml of such solution in a polyethylene bottle with a cover dropper, one such bottle in a cardboard pack.
The oculentum is usually homogeneous, pale yellow color. 3 g of such ointment in a tuba, one such tuba in a cardboard pack.
Pharmacological action
Drug possesses antibacterial action.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Ofloxacin is ftorkhinolony (to derivatives of hinolonovy acid), the antibacterial drug having bactericidal effect.
Range of antibacterial action of an ofloksatsin: facultative anaerobes, strict anaerobes, aerobes and some other bacteria, for example Chlamydia.
Frequency of occurrence of the acquired resistance of separate species of microorganisms varies depending on the region and changes eventually. Therefore the basic for purpose of the correct treatment of infections is the possession of information on local resistance. Cross resistance of an ofloksatsin and other ftorkhinolon is possible.
The most sensitive types:
- gram-positive aerobic bacteria of Staphylococcus aureus, Bacillus spp.;
- gram-negative aerobic bacteria of Acinetobacter lwoffi, Acinetobacter baumannii, Escherichia coli, Haemophilus influenzae, Klebsiella oxytoca, Enterobacter cloacae, Proteus mirabilis, Haemophilus parainfluenzae, Moraxella catarrhalis, Klebsiella pneumoniae, Serratia marcescens.
Types at which presence of the acquired resistance is possible:
- gram-positive aerobic bacteria of Enterococcus faecalis, Corynebacterium spp., metsitilenrezistentny strains of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis;
- gram-negative aerobic bacteria of Stenotrophomonas maltophilia, Pseudomonas aeruginosa.
The types possessing inborn resistance:
- gram-positive aerobic bacteria of Enterococcus spp.
Pharmacokinetics
Efficiency of drug depends on a ratio of its greatest concentration in fabric and the minimum overwhelming concentration of the activator.
At repeated use medicine collects in a vitreous in medical concentration. After administration of drug of 5 times a day with exposure 5 minutes, in 1-2 hours concentration in intraocular liquid becomes the maximum, and 5-6 more hours it decreases to zero.
Floksal elimination half-life at its regular use makes from 3 to 7 hours of blood.
Indications to use
The infectious diseases of front department of an organ of sight caused by microorganisms sensitive to drug:
- helcoma;
- barley;
- blepharitis;
- conjunctivitis;
- keratitis;
- dacryocystitis;
- Chlamidia damage of eyes.
And also prevention and therapy of infectious complications after surgical interventions and injuries of an eye.
Contraindications
- Breastfeeding.
- Pregnancy.
- Allergy to drug components.
Side effects
The expressed reactions after regular use of an ofloksatsin develop seldom, the majority of them are reversible.
Directly after use of drug there can be a sight illegibility which disappears in several minutes.
- From immunity: a conjunctiva hyperemia, a Quincke's edema, a burning sensation in an eye, anaphylactic reactions, stomatopharynx hypostasis.
- From a nervous system: dizziness.
- From an eye: a sensation of discomfort in eyes, irritation, a keratitis, a sight illegibility, conjunctivitis, photophobia, a xerophthalmus, dacryagogue.
- From digestive organs: nausea.
- From skin: face edemas and periorbital area.
There are data that at local use Stephens-Johnson's syndrome and a toxic epidermal necrosis very seldom developed. Relationship of cause and effect of such manifestations with ofloksotsiny is not established.
Application instruction of Floksal
Floksal the application instruction 3–4 times a day are offered to dig in eye drops on 1 drop for an eyelid of a sore eye.
The instruction of an oculentum Floksal also recommends to use drug konjyunktivalno. The ointment strip to 1,5 cm is put in a conjunctival sac by 2–3 times a day, at Chlamidia defeat — 5 times a day. Ointment and drops for eyes is not recommended to apply more than 2 weeks.
It is possible to combine an oculentum and drops Floksal. At joint local reception ointment the last needs to use more than one medicine.
Overdose
Messages on cases of overdose were not. Therapy – symptomatic, it is necessary to wash out quickly an eye clear water.
Interaction
Features of interaction are not studied.
Terms of sale
Medicine is sold only according to the recipe of the doctor.
Storage conditions
To protect from children. Drug needs to be stored the dark place at a temperature up to 25 °C. After opening of a tuba and or a bottle it is possible to use drug no more than 6 weeks.
Period of validity
3 years.
Special instructions
If there was an allergic reaction to Floksal, reception needs to be stopped.
Before the first administration of drug it is recommended to carry out microbiological crops of the material taken from a conjunctival sac for detection of sensitivity of bacteria to an ofloksatsin.
At long-term use development of bacterial resistance and emergence of microorganisms, insensitive to drug, is possible. If symptoms amplified or clinical improvement is absent it is necessary to stop treatment by Floksal and to begin alternative therapy.
During treatment it is forbidden to use rigid contact lenses. Therefore it is necessary to remove such lenses before use of drug and to dress them in 20 minutes after an instillation.
Floksal's analogs
The following analogs of eye drops Floksal are known: Vigamoks, Unifloks.
Zdravzona
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Drugstore of IFC
- Floksal of a hl drop. 0.3% of 5 ml, Dr. Gerhard Manngermaniyaa class="drug-price-link" href="/javascript:if(confirm(%27medicalmed.us/goto/ad.admitad.com/g/fa400bb23009dcb39bb46fa0457639/?i=5&ulp=http%3A%2F%2Fwww.apteka-ifk.ru%2Fart%2F41018%2F \n\nThis file was not retrieved by Teleport Pro, because it is addressed on a path excluded by the site\%27s Robot Exclusion parameters. (Teleport Pro\%27s compliance with this system is optional; see the Project Properties, Netiquette page.) \n\nDo you want to open it from the server?%27))window.location=%27medicalmed.us/goto/ad.admitad.com/g/fa400bb23009dcb39bb46fa0457639/?i=5&ulp=http%3A%2F%2Fwww.apteka-ifk.ru%2Fart%2F41018%2F%27" tppabs="medicalmed.us/goto/ad.admitad.com/g/fa400bb23009dcb39bb46fa0457639/?i=5&ulp=http%3A%2F%2Fwww.apteka-ifk.ru%2Fart%2F41018%2F" target="_blank">
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Apteka24
- Floksal oculentum of 0.3% 3gdoktor Gerhard Mann (Germany)a class="drug-price-link" href="/javascript:if(confirm(%27medicalmed.us/goto/www.apteka24.com.ua/20491/ \n\nThis file was not retrieved by Teleport Pro, because it is addressed on a path excluded by the site\%27s Robot Exclusion parameters. (Teleport Pro\%27s compliance with this system is optional; see the Project Properties, Netiquette page.) \n\nDo you want to open it from the server?%27))window.location=%27medicalmed.us/goto/www.apteka24.com.ua/20491/%27" tppabs="medicalmed.us/goto/www.apteka24.com.ua/20491/" target="_blank">
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BIOSPHERE
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