Фолликулин Drug photo

The description is actual on 13.07.2016

  • Latin name: Folliculin
  • ATH code: G03CA07
  • Active ingredient: Estrone (Oestronum)
  • Producer: LLC Pharmaceutical Company Zdorovye


In 1 ml of solution — estrone of 1 mg. Oil peach, as excipient.

Release form

Solutio oleosa of 0,1% on 1 ml.

Pharmacological action


Pharmacodynamics and pharmacokinetics


Hormone folliculin (estrone) is synthesized at women by a follicular epithelium of an ovary, since the puberty period to a climacteric. It influences development of secondary sexual characteristics in female type. Under its action follicles and ova ripen, there is a proliferation of an endometria and regulation of a menstrual cycle. If the ovum is not impregnated, under the influence of folliculin there is a rejection mucous together with an unfertilized ovum. The drug Folliculin — contains the natural hormone of ovaries received from urine of animal or pregnant women.

Stimulates development of a uterus at its underdevelopment, eliminates the disturbances arising at women in a climacteric in connection with insufficient function of ovaries. Use with progesterone regulates a menstrual cycle and function of a child-bearing. Stimulates production of follicle-stimulating hormone in small doses, and slows down it at use in high doses. Detains in an organism water and sodium, improves a glucose expenditure. Has nonspecific effects: strengthens reparative processes and epithelization of mucous. Reduces cholesterol level in blood.


Estrone is well absorbed, necessary concentration in plasma remains 4–5 days. It is metabolized in a liver. It is removed with bile, and in intestines there is a reabsorption and repeated receipt in a liver. Finally in the form of conjugates it is removed by kidneys. Removal speed in many respects depends on a state (phases of a menstrual cycle, pregnancy), and also age of the patient.

Indications to use


  • Mastopathy;
  • hypersensitivity;
  • endometritis;
  • new growths of generative organs at women till 60 flyings;
  • uterine bleedings and predisposition to them;
  • hyper oestrogenic phase in a climacteric;
  • liver failure;
  • pregnancy;
  • thrombophlebitis and thromboembolisms in the anamnesis;
  • age till 14 flyings.

With care appoint drug at epilepsy, a depression, an arterial hypertension, diseases of a gall bladder.

Side effects

  • The century swelled;
  • nausea, vomiting;
  • erythropenia;
  • headache;
  • allergic reactions;
  • dizziness;
  • congestive jaundice;
  • uterine bleedings (at prolonged use);
  • disturbance of a water salt metabolism;
  • sclerosis of ovaries;
  • the feminization phenomena  at men.

Folliculin, application instruction (Way and dosage)

Solution of Folliculin is entered intramusculary, previously having warmed an ampoule in a hand. In case of loss of crystals, the ampoule is heated on the water bath of 15 — 20 min. Disappearance of crystals and absence them when cooling solution to 37 °C demonstrates that drug is good for use. At treatment minimal effective doses are selected.

At primary amenorrhea and an underdevelopment of generative organs appoint 10 000 — 20 000 PIECES every day 1-2 months before increase in the sizes of a uterus. In the subsequent appoint intramusculary progesterone on 5 mg daily.

At a secondary amenorrhea — 10 000 PIECES every day within 15 days. Courses are repeated.

At an oligomenorrhea, algodismenory, infertility against the lowered function of ovaries enter 5000-10 000 PIECES every day within 15 days after the termination of periods.

In a climacteric with the expressed symptoms (the angioneurotic phenomena, a depression) — on 5 000-10 000 PIECES every day till 10-15 injections on a course.

At weakness of patrimonial activity — 40 000-50 000 PIECES before administration of parturifacient drugs. Before an initiation of treatment pass careful gynecologic inspection in all cases.


It is shown by symptoms: strengthening of nausea, headache, emergence of uterine bleeding. Treatment: symptomatic.


Folic acid and hormones of a thyroid gland strengthen effect of estrone, and anti-oestrogenic drugs, phenobarbital and rifampicin — weaken. Estrone strengthens effect of antiarrhytmic, gipokholesterinemichesky, hypotensive drugs, anticoagulants, diuretics, glucocorticoids, antidepressants, hormones of a thyroid gland. Reduce concentration of hormone in blood — ampicillin, tetracycline, levomycetinum, Neomycinum, streptocides, and ascorbic acid — raises.

Terms of sale

It is released according to the recipe.

Storage conditions

Temperature of storage is 8-15 °C.

Period of validity

5 years.

Analogs of Folliculin

Natural hormones — Estrone, Oestradiol, Estriol; ethers of natural hormones — Oestradiol valeriat, Dipropionas, propionate, semi-synthetic drugs — Mestranol, Ethinylestradiol, Microfollinum, synthetic drugs — Sinestrolum, Diethylstulbestrole, Dimoestrolum, Oktestrol, Sygethinum, Progynonum, Thelestrinum, Telekinin.

About Folliculin

The drugs containing natural hormone oestradiol or estrone are applied to a stop of juvenile bleeding at girls. Oestrogenic therapy is obligatory for maintenance of a female phenotype after a hysterectomy with appendages at young women and girls. Natural estrogen replaced Microfollinum which contains a high dose of synthetic ethinylestradiol — 50 mkg. Replacement hormonal therapy by natural estrogen exerts full impact in comparison with Microfollinum that allows to apply it is long.

There is not a lot of reviews of drug that is connected with absence it in pharmacy chain. Judging by responses most often it was applied at disfunktsinalny uterine bleedings, the amenorrhea connected with reduced function of a hypophysis and ovaries. Schemes of hormonal therapy at these diseases were different and included estrogen in combination with progesterone.

At cancelled abortion (a delay in a uterus of the died fetal egg) for creation of an oestrogenic background folliculin in oil within 3 days then the drugs reducing a uterus was also appointed. Are available About drug, confirming its efficiency at treatment of a natural climax and postkastratsionny (after removal of ovaries).

"… Recently it is impossible to buy Folliculin ampoules, and it is necessary to me as periodically I accept courses at a climax".

Very many patients note local reaction to administration of drug in the form of consolidation of fabrics, an itch and rashes:

  • "… Was in hospital pricked folliculin for preparation of a neck for childbirth. Now having on site pricked pruritic spots".
  • "… All women who lay with me in chamber after the delivery had painful cones and an itch the field of pricks of folliculin".


  • Folliculin 0,1%/1 of ml No. 10 solution for in.masl. Health - the pharmaceutical company (Ukraine)
to show still
Section: Gynecologic Hormonal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Folliculin surely consult with the attending physician.