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In 1 tablet of an alendronat of sodium of 10 mg or 70 mg.
Cellulose microcrystallic, lactose, sodium of a kroskarmeloz, magnesium stearate, wax — as excipients.
Suppression of a bone resorption.
Pharmacodynamics and pharmacokinetics
Non-hormonal inhibitor of a bone resorption from group of biphosphonates — analogs of pyrophosphates. It is localized under osteoclasts in zones of a resorption of a bone and inhibits this process. In its chemical structure there is P-O-P - communication by means of which it joins in fabric and suppresses osteoclasts. The resorption and formation of a new bone tissue occur in parallel therefore process of formation of a bone decreases too, however it is less, than the resorption also results increase in a bone tissue.
Fosamaks stimulates bone formation, increases the mineral density of a bone (MDB), well influences forming of a normal bone tissue, reduces risk of changes at osteoporosis.
In therapeutic doses does not cause osteomalacy. Its efficiency at the osteoporosis at men and women caused by reception of glucocorticoids is proved and also at osteoporosis at men.
Osteoporosis involution at reception of this drug is proved by researches — the bone acquires normal structure and a mineralization, indicators of disintegration of collagen of a bone and calcium in urine decrease.
Efficiency of drug does not depend on age, function of kidneys and initial speed of processes of an exchange in a bone tissue.
At reception on an empty stomach for 2 h before meal bioavailability makes 0,64% if administration of drug is carried out for 1 h till a breakfast, then bioavailability decreases by 40%.
The concomitant use of coffee reduces bioavailability by 60%. Reception of Prednisolonum does not exert impact on bioavailability of drug. Linkng with proteins makes 78%. Later in/in maintaining in blood in 6 h concentration decreases by 95%. With urine vyvoditsya50 drug %. A final elimination half-life — 10 years.
Indications to use
- osteoporosis at women in a postmenopause;
- hypercalcemia (at malignant tumors);
- osteoporosis at men;
- Pedzhet's illness;
- the osteoporosis which arose against reception of glucocorticoids;
- prevention of osteoporosis.
- diseases of upper parts of a gastrointestinal tract (achalasia, dysphagy, gullet strictures, duodenitis, peptic ulcer);
- hypocalcemia (hypoparathyroidism, calcium malabsorption, deficit of vitamin D);
- pregnancy, feeding by a breast;
- children's age;
- the expressed renal failure;
- hypersensitivity to drug.
- urticaria, rash, itch, it is rare — a Quincke's disease;
- dizziness, vertigo;
- ostealgia, mialgiya, arthralgia;
- peripheral hypostases;
- esophagitis, ulcers of a gullet, stomatopharynx, stomach.
The instruction to Fosamaks (A way and a dosage)
Once a day is accepted inside, it is desirable in the morning, without chewing, for 2 h before meal. It is necessary to wash down a tablet only with water as other drinks reduce absorption.
At Pedzhet's illness — 40 mg not less than 6 months.
For prevention of osteoporosis appoint 5 mg/days.
At osteoporosis in a postmenopause — 10 mg/days. The release form in tablets on 70 mg which accept once a week is had. For weekly reception there is also a combined drug with vitamin D. Reception of 10 mg of drug on productivity and emergence of side reactions is equivalent to weekly reception on 70 mg.
The application instruction of Fosamaks contains the warning that for the purpose of reduction of an irritant action of drug by a gullet it is necessary to take a pill in the morning, washing down with a glass of water then it is impossible to lay down within 30 min. If to take a pill before going to bed, the risk of emergence of an esophagitis and other diseases of a gullet increases. Lecheniyeneobkhodimo to combine with the diet rich with Ca2+ salts.
Specific therapy does not exist. For binding of an alendronat to accept milk or antacids. It is not necessary to cause vomiting.
At combined use with antacids, drugs of calcium disturbance of absorption of an alendronat therefore it is necessary to carry reception of these drugs on time is noted.
Ranitidine increases Fosamaks's bioavailability twice.
The undesirable phenomena from a gastrointestinal tract increases if to accept Fosamaks together with acetylsalicylic acid and other NPVP.
At combined use with estrogen safety of treatment corresponds to safety at use of each drug independently.
Terms of sale
According to the recipe.
At a temperature from 150 With to 250 C.
Period of validity
Ostalon, Ostemaks, Osteofos, Ralenost, Alendronat Pliva, Strongos, Tevanat, Alental, Lindron.
Drugs of the first line for treatment of osteoporosis are bisfosfonata. Their high performance and rather good tolerance are proved. In Russia it is registered preparatalendronovy acid of Fosamaks. Everything, accepting it, note good effect which is confirmed not only reduction of ostealgias and joints, but also inspections (biochemical, radiological, densitometry). Treatment of osteoporosis lasts 3–5 years.
"I accept Fasomaks 1 year 2 months. Improvements are".
With the preventive purpose at low MPK in an early menopause accept 35 mg once a week.
"I accepted 6 months, I feel well, improvement is. It is necessary to adhere to the instruction strictly!"
There are messages on what Fosamaks applied in complex treatment at a generalized periodontal disease (10 mg within three months).
Comments of patients on Fosamaks concern, first of all, side effects of drug. Many patients accepting drug once a week note the minimum dispeptic frustration in day of its reception. These phenomena passed independently in 2-3 months.
Damages of a gullet were not registered, but cases of an exacerbation of gastritis or a peptic ulcer occurred at patients who had these diseases earlier.
"…. Fosamaks I drink the second year, there were problems with a stomach — it began to ache a bit".
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