Фосаванс Drug photo

The description is actual on 21.07.2016

  • Latin name: Fosavance
  • ATH code: M05BB03
  • Active ingredient: Alendronovy acid + Kolekaltsiferol (Acidum alendronicum + Colecalciferolum)
  • Producer: Frosst Iberica (Spain)


In 1 tablet of alendronovy acid — 70 mg and a kolekaltsiferola of 70 mkg. Lactose, silicon dioxide, cellulose microcrystallic, magnesium stearate, sodium of a kroskarmelloz, as excipients.

Release form

Tablets of 70 mg / 70 mkg No. 4.

Pharmacological action

Correction of an exchange of calcium in a bone tissue.

Pharmacodynamics and pharmacokinetics


Bisfosfonat inhibiting a resorption of a bone tissue. Active agent alendronovy acid is localized in a zone of an active resorption where makes the action, without having significant effect on formation of new fabric. Suppression of a resorption reduces education new, but to a lesser extent that attracts the progressing increase in bone weight.

Alendronat is built in a matrix of again forming bone tissue, in therapeutic doses does not cause osteomalacy. D3 vitamin (kolekaltsiferol) is produced in skin, in the absence of a sunlight its development decreases therefore the necessary quantity has to arrive with food. Vitamin strengthens absorption of calcium and phosphates in intestines, regulates calcium level in blood, is necessary for forming of a bone tissue. Its insufficiency causes loss of bone weight (negative balance of calcium) and risk of changes at osteoporosis.


Bioavailability of alendronovy acid at reception on an empty stomach (in 2 hours prior to a breakfast) makes 0,64% at women. It is insignificant at a concomitant use with food, reception from coffee reduces bioavailability by 60%. Concentration of drug in blood insignificant. Linkng of an alendronat with proteins about 78%. After absorption, D3 vitamin is found in blood as a part of chylomicrons, is quickly distributed (more in a liver), here is metabolized to an active form of vitamin.

Insignificant amounts of vitamin get to fatty tissue, accumulate for the subsequent emission in a blood stream here. Circulates in a blood-groove in the connected view with protein. Data on a metabolism of an alendronat are absent. 50% of sodium of an alendronat are removed with urine in 72 hours, and a final elimination half-life — more than 10 years, that is it is slowly released from a bone tissue. D3 vitamin elimination half-life about 24 hours.

Indications to use

  • disturbances of an exchange of calcium;
  • the osteoporosis which is not specified at men and women;
  • post-menopausal osteoporosis.


  • hypersensitivity;
  • gullet diseases (strictures or achalasia);
  • hypocalcemia;
  • renal failure;
  • pregnancy;
  • feeding period breast;
  • age till 18 flyings;
  • hypoparathyrosis;
  • calcium malabsorption;
  • hereditary deficit of lactase.

With care it is appointed at an exacerbation of gastritis, an esophagitis, a duodenitis, at gastrointestinal bleeding, a hypercalcemia and a hypercalcuria.

Side effects

Fosavans, application instruction (Way and dosage)

Accept inside on 1 tablet in 30 minutes prior to a breakfast, washing down with a large amount of water for fast receipt of a tablet in a stomach. It is necessary to exclude any drinks for a zapivaniye as they can reduce absorption. The recommended dose is accepted in the same day once a week.

For reduction of side reactions in the form of irritation of a gullet drug should be accepted right after rise from a bed, not to chew and not to rassasyvat tablets, and at least within 30 minutes after that not to accept horizontal position.

Reception of tablets fills need for vitamin D within a week. If intake of calcium and vitamin C food is not enough, then it is recommended to accept in addition them in the form of drugs. At the admission of reception it is necessary to accept drug in the morning of the next day.

Fosavans Forte contains a double dose of a kolekaltsiferol (Vit. D3) — 140 mkg in this connection the daily dose of vitamin will make 800 ME. It is more reasonable to patients who do not receive in addition this vitamin C food to take this form of drug.


Overdose is shown by heartburn, an esophagitis, a stomach/gullet ulcer. In blood the hypocalcemia and a hypophosphatemia is found. For binding of an alendronat of sodium it is necessary to accept antacids or milk. It is not necessary to cause vomiting as it will aggravate irritation of a gullet. The patient should not accept horizontal position.


Reception along with antacids and drugs of calcium worsens absorption of active agent. Reception of other medicines is possible in 1,5-2 hours. Worsen vitamin D absorption: Colestyraminum, Kolestipol, Olestra, Orlistat. Diuretics, Cimetidinum, anticonvulsant drugs accelerate a vitamin catabolism.

Terms of sale

According to the recipe.

Storage conditions

Temperature is up to 25 °C.

Period of validity

18 months.

Fosavans's analogs

Coincidence on the ATH code of the 4th level:

Alendronat, Tevabon, Ostalon, Osteohoney, Fosamaks, Tevanat, Foroza, Osterepar.

About Fosavans

Drug of Fosavans favourably differs from other biophosphonates (for example, from Fosamaks and Ksidifon) in the fact that contains vitamin D in a dose 2800 ME or a dose 5600 ME (Fosavans Forte) therefore need to accept in addition drugs of calcium and vitamin D disappears. With drug of the patient receives a week dose of vitamin — it is important as 2/3 women in a postmenopause suffer from the expressed hypovitaminosis. At treatment this drug notes the best result — level Vit is normalized. The increase of density of a bone tissue occurs D and more effectively. It is possible to tell that this essentially new medicine in treatment of osteoporosis.

Judging by responses, drug is well transferred by many. If to follow instructions, then irritation mucous a digestive tract meets seldom. Patients were informed by doctors on need of the termination of administration of drug at emergence of undesirable symptoms (a dysphagy, gullet pains when swallowing, heartburn) therefore terrible complications in the form of cankers mucous were not noted. Besides, clinical trials confirmed higher level of portability of this drug in comparison with Fosamaks. It is also proved that long reception (during 10 flyings) attracts increase of density of a bone for 13% and decrease in losses of a bone tissue which happened earlier.

  • "… Accepted at osteoporosis of Fosavans 1,5 years. Pobochek was not, it is necessary to accept correctly as it is written to instructions".
  • "… Drug good — me was succeeded to suspend a course of a disease and "to increase" bone density. But the problem is that at my osteoporosis it should be accepted very long".
  • "… I accept the third month, periodically I do densitometry. In a month of a bone became stronger, I will continue treatment".
  • "… After densitometry wrote out this medicine, but told to drink every two weeks. Probably not so everything is bad".
  • "… Drank Fosavans's course and threw. Problems with digestion — a lock constant began".


  • Fosavans 70 mg No. 4 of a tablet
  • Fosavans 70 mg +70mkg No. 4 tabletkifrosst Iberika S. A./Merk Sharp and Doum
  • Fosavans forte 70 mg + 140 mkg No. 4 tabletkifrosst Iberika S. A./Merk Sharp and Doum

Drugstore of IFC

  • Fosavans forte tbl 70 mg +140mkg No. 4, Merck Sharp & Dohmeniderlandy
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  • Fosavans Plus 70 mg / 5600 ME No. 4 of the tab. Frost Iberika, S. A. (Spain)
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Section: Others
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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