Phthorafurum

Фторафур Drug photo

The description is actual on 21.07.2016

  • Latin name: Ftorafur
  • ATH code: L01BC03
  • Active ingredient: Tegafurum (Tegafur)
  • Producer: Gniiskls (Russia); Nizhpharm (Russia); "Гриндекс" Public joint-stock company (Latvia); IOS of AN of Latvia (Latvia)

Structure

Tegafurum, stearic acid, titanium dioxide, gelatin, quinolinic yellow.

Release form

Capsules gelatinous 400 mg of yellow color in polyethylene bottles in a cardboard pack No. 100.

Pharmacological action

Antineoplastic, cytostatic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Drug with the antineoplastic action caused by disturbance of process of synthesis of DNA/RNA. Ftoruratsil who is formed in the course of hydrolysis inhibits a timidilatsintetaza and process of synthesis of DNA, is implemented instead of uracil into structure of RNA, causing defect of its structure, breaks proliferation of cells.

In cells of malignant new growths turns into fluorine-dezoksiuridin-monophosphate which is phosphorylated further in triphosphate and is implemented into structure of RNA, and the monophosphate of a floksuridin inhibiting a timidilatsintetaza. Is rather less toxic.

Pharmacokinetics

Drug is quickly absorbed from a gastrointestinal tract. Cmax is reached in 5-6 hours after introduction. Bioavailability at the level of 95%. Gets through GEB. It Biotransformirutsya in a liver. Most pharmacological an active metabolite is 5-ftoruratsit.

Indications to use

Malignant tumors of a gastrointestinal tract, ovaries, uterus, mammary gland, liver, prostate, bladder, skin lymphoma, bazalioma, diffusion neurodermatitis.

Contraindications

Diseases in an end-stage, dysfunctions of kidneys/liver, acute profuse bleedings, pregnancy, high sensitivity to drug, a lactation, a leukopenia, anemia, thrombocytopenia. To take with caution to patients with infectious diseases, dysfunction of marrow, a glucose metabolism, tendency to bleedings.

Side effects

Thrombocytopenia, leukopenia, anemia, anorexia, diarrhea, vomiting, confusion of consciousness, euphoria, drowsiness, dizziness, stenocardia, myocardial infarction, ischemic heart disease, diplopia, alopecia, allergic reactions.

Phthorafurum, application instruction (Way and dosage)

To accept inside in 30 minutes prior to or after meal. A daily dose at monotherapy — 1,2-1,6 g (20-30 mg/kg of body weight, 3-4 capsules), but no more than 2 g; to accept in two steps every 12 hours. A course dose — 30-40 g; Duration of treatment is 28 days. In schemes of a combination therapy the dose of drug decreases. In 1,5-2 months the course of treatment can be repeated.

Overdose

It is shown by oppression of a hemogenesis, strengthening of side effects from TsNS and gastrointestinal tract.

Interaction

At joint reception of Phthorafurum with Phenytoinum therapeutic action of the last amplifies. It is incompatible with anthracycline antibiotics, Cytarabinum, diazepam. Phthorafurum strengthens action of radiation therapy and other chemotherapeutic means. Strengthens (mutually) action of a methotrexate.

Terms of sale

Prescription issue.

Storage conditions

At a temperature up to 25 °C.

Period of validity

48 months.

Analogs

Coincidence on the ATH code of the 4th level:

With similar therapeutic action treat drugs: Aleksan, Vizflur, Gemtsibin, Vizgem, Gemtsitabin, Gemzar, Gematiks, Onkogy, Flura-5, Ftoruratsil, Kseloda, Dertsin, Flyuorouratsil, Cytarabinum, Tsitogem, Cytosarum and others.

About Phthorafurum

Oral administration of Phthorafurum the cytostatics allows to maintain in tumoral fabric optimum and constant concentration, providing thereby rather high performance of therapy with decrease in frequency of manifestations of toxicity and improving quality of life of patients – the most important component of chemotherapy. Results of treatment by drug demonstrate that efficiency of Phthorafurum is sufficient is high and is shown by active antineoplastic action at rather low toxic effect.

Many patients write that the tablets Phthorafurum allow them to transfer chemotherapy much easier. Taking into account an economic component, Phthorafurum at the price is available to patients practically of all social groups, without conceding at the same time in efficiency in comparison with expensive drugs. All this allows to consider Phthorafurum as drug of the choice both in the monochemotherapy mode, and in schemes of the combined chemotherapy.

Zdravzona

  • Phthorafurum of 400 mg No. 100 kapsulygrindex

Drugstore of IFC

  • Phthorafurum kaps 400 mg No. 100, Grindexlatviya
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Apteka24

  • Ftorafurgrindeks (Latvia)

BIOSPHERE

  • Phthorafurum of 400 mg No. 100 kaps.
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Section: Antineoplastic
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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