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Cream includes Fucidinum of in number of 1 grams the 10th acetate of a hydrocortisone and 20 mg of fuzidovy acid.
Additional substances: cetyl alcohol, water, liquid paraffin, polysorbate, glitserol 85%, soft white paraffin, potassium sorbate, Acidum hydrochloricum, butylhydroxyanisole.
White homogeneous cream. 15 grams of cream in a metal tuba, 1 tuba in a paper pack.
Local antibacterial, anti-inflammatory and glucocorticoid action.
Pharmacodynamics and pharmacokinetics
The Bikomponentny drug intended for external use. Combines antipruritic and anti-inflammatory action of a hydrocortisone with the bacteriostatic effect of fuzidovy acid based on disturbance of biosynthesis of protein in an activator cell.
Gram-positive microorganisms and gram-negative cocci are most sensitive to the drug Fucidinum: Streptococcus pyogenes, Neisseria meningitidis and gonorrhoeae, Staphylococcus aureus and epidemridis, Corynebacterium minutissimum, Nocardia asteroides, and also representatives of the sorts Pseudomonas and Clostridium.
Drug is not active concerning colibacillus, and also representatives of the sorts Salmonella and Proteus, protozoa and mushrooms.
The Antibakterilny effect of fuzidovy acid is not weakened in the presence of a hydrocortisone.
About 2% of active ingredients get into skin the field of drawing. System absorption weak.
Fuzidovy acid is emitted generally with bile, and only a small small amount is evacuated from an organism with urine.
The soaked-up hydrocortisone quickly is transformed and removed with urine.
Indications to use
The atopic dermatitis complicated by the infection sensitive to fuzidovy acid.
- perioral dermatitis;
- primary infectious damages of skin caused by mushrooms, bacteria or viruses (herpes, chicken pox);
- allergy to drug components;
- pink eels;
- skin complications of tuberculosis or syphilis;
- age less than 2 years.
Fucidinum of is taken with caution during pregnancy and a lactation.
- Allergic phenomena: eczema, urticaria, Quincke's edema.
- Dermatological phenomena: contact dermatitis, irritation of skin, eczema, rash and itch of skin, xeroderma, depigmentation.
- The reactions connected with presence of a hydrocortisone: teleangiectasia and striya, skin atrophy, hypertrichosis, depigmentation, folliculitis, contact allergic dermatitis, perioral dermatitis, oppression of activity of adrenal glands.
Application instruction (Way and dosage)
Cream is applied and used only outwardly.
Cream Fucidinum of, application instruction
To persons 2 years are more senior appoint to apply with a thin layer on the struck part of skin up to 3 times a day. Treatment duration usually makes 14 days.
There are no data on the registered overdose cases.
Interaction with other medicines was not investigated.
Terms of sale
It is possible to get strictly according to the recipe.
To store at a temperature up to 24 degrees Celsius. To protect from children.
Period of validity
It is impossible to apply cream on skin a century as fuzidovy acid causes irritation of fabrics of a conjunctiva.
Cream includes butylhydroxyanisole, sorbate of potassium and cetyl alcohol in the structure. These substances are the reason of development of the local allergic skin phenomena. Butilgidroksianizol can also serve as the reason of irritation mucous and an eye.
When using fuzidovy acid development of bacterial resistance is not excluded. The long or regularly repeating use is capable to increase risk of resistance to antibacterial drugs. Use of constant combinations of glucocorticosteroids with an antibiotic should not last more than 2 weeks because of ability of the first to mask symptoms of an infection or reactions of hypersensitivity.
It is recommended to avoid long use of local glucocorticosteroids because it is capable to lead to suppression of work of adrenal glands even at small system absorption. After long-term treatment by glucocorticosteroids atrophic changes on face skin and other parts of a body can develop.
Influence of medicine on ability to driving is not revealed.
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