Ганатон Drug photo

The description is actual on 06.06.2014

  • Latin name: Ganaton
  • ATH code: A03FA
  • Active ingredient: Itoprid (Itopride)
  • Producer: ABBOTT JAPAN, Co. Ltd. (Japan)


One tablet of Ganaton contains as active agent a hydrochloride of an itoprid in number of 50 mg. As excipients contain: corn starch — 15 mg, lactose — 34.975 mg, a karmelloza — 20 mg, silicon anhydrous acid — 4 mg, magnesium stearate — 1 mg, a gipromelloza — 4.4 mg, titanium dioxide — 0.2 mg, a macrogoal of 6000 — 0.4 mg, wax a Brazilian wax palm — 0.025 mg.

Release form

Drug is issued in tablets, coated light color, roundish, with a strip at one edge and a text "HC 803 ". Seven, ten or fourteen such tablets in the blister. Five, four, three, two or one such blister in a cardboard pack.

Pharmacological action

Drug renders the action stimulating a tone and motility of a stomach and intestines.

Pharmacodynamics and pharmacokinetics


Action mechanism. The hydrochloride of an itoprid activates a stomach peristaltics due to suppression of D2 - dopamine receptors and acetylcholinesterase. Itoprid suppresses destruction of acetylcholine and strengthens its release.

The hydrochloride of an itoprid also renders antiemetic effect inhibiting D2 receptors, localized in trigger area, and causes dozozavisimy oppression of the vomiting caused by Apomorphinum.

Drug activates propulsive motility of a stomach and accelerates transit of food on a stomach and its emptying. Does not influence concentration of gastrin in blood serum.


Absorption. Drug is quickly and almost entirely soaked up from a stomach and intestines. Bioavailability makes 60% — it is connected with transformations of a molecule at the first passing through liver tissues. Meal does not influence bioavailability indicators.

After intake of 50 mg of a hydrochloride of an itoprid the maximum concentration is reached in half an hour. At the following administrations of drug by the number from 50 to 200 mg three times a day within a week the pharmacokinetics of the drug and its derivatives did not change, and the effect of cumulation was not observed.

Itoprid contacts plasma proteins (albumine, to a lesser extent alpha 1-acid glycoproteins) for 96%. It is actively carried on fabrics and comes to light in big concentration in a small bowel, kidneys, adrenal glands, a liver and a stomach. Also the brain in insignificant quantities gets in back. It is capable to get into breast milk.

Metabolism. Drug undergoes active transformation in a liver. Three metabolites are known, only one of them shows the weak activity which is not of great importance.

Itoprid decays under the influence of flavinzavisimy monooxygenase, its concentration and efficiency at the person depends on inborn polymorphism. At patients with a trimetilaminuriya the elimination half-life of an itoprid increases.

Removal. Drug and its metabolites are emitted with urine. The terminal elimination half-life of an itoprid makes 6 hours.

Indications to Ganaton's use

Drug is used for treatment of functional dyspepsia of not ulcer character (chronic gastritis). Use of drug is proved for stopping:

  • feelings of fast saturation;
  • abdominal distentions;
  • discomfort and pain in the upper floor of an abdominal cavity;
  • anorexias;
  • nausea;
  • heartburn;
  • vomitings.


  • Gastric or intestinal bleeding, mechanical obstruction or perforation of a gastrointestinal tract.
  • Period of breastfeeding (lactation).
  • Pregnancy.
  • The children's age is younger than 16 years.
  • Sensitization to an itoprid or other component of drug.

Side effects

During clinical trials (1-3 phases) itoprid it was transferred by patients well, about serious by-effects it was not reported. The bulk of complaints to side reactions was made: headache, diarrhea, abdominal pain.

Deviation of indicators of blood, observed during researches: leukopenia, increase in level of prolactin.

The most often this medicine can cause the following by-effects:

  • from system of immunity — an acute anaphylaxis;
  • from closed glands — a gynecomastia, increase in level of prolactin;
  • from a peripheral and central nervous system — a headache, dizziness, a tremor;
  • from system of digestion — diarrhea, abdominal pains, a lock, salivation, nausea;
  • from gepatobiliarny system — jaundice;
  • from integuments — rash, a hyperemia, an itch;
  • disturbances from clinical analyses — increase in the ALT, nuclear Heating Plant level, an alkaline phosphatase, GGT, bilirubin.

Application instruction of Ganaton

The application instruction of Ganaton recommends to take this medicine inside on 50 mg (1 tablet) three times a day before meal. The recommended day dose of drug – 3 tablets. This dose can be reduced proceeding from age of the patient.


About cases of overdose there are no messages. If it nevertheless came, it is necessary to make a gastric lavage and to begin a symptomatic treatment.


At a concomitant use of Ganaton with diazepam, warfarin, diclofenac, a hydrochloride of a tiklopidin, nifedipine and a hydrochloride of a nikardipin of disturbances of interaction of an itoprid with proteins of blood it is not observed.

Itoprid improves motility of a stomach owing to what it influences absorption of other substances which are at the same time applied with Ganaton. Extra care needs to be observed when using drugs with the small therapeutic index prolonged by release of active ingredient and a kishechnorastvorimy cover.

Anticholinergic drugs weaken action of an itoprid.

Terms of sale

Drug is released strictly according to the recipe of the doctor.

Storage conditions

To store in the place, unavailable to children.

Period of validity

Three years.

Special instructions

Hydrochloride elderly people need to appoint Itoprid with care. It is necessary to watch health of such patients as at them damages of kidneys, a liver and other diseases or parallel therapy of other medicines meet more often.

At the solution of a question of driving it is necessary to consider a possibility of development of dizziness.

Ganaton's analogs

Coincidence on the ATH code of the 4th level:

The most known analogs of Ganaton: Zirid (Slovakia), Itomed (Czech Republic), Primer (India/Great Britain). A form of release of all above-mentioned analogs – tablets. The price of analogs of Ganaton, as a rule, fluctuates in the same price category or below it.


  • Ganaton of 50 mg No. 70 of a tablet
  • Ganaton of 50 mg No. 40 of a tablet
  • Ganaton of 50 mg No. 10 of a tablet

Drugstore of IFC

  • Ganaton tbl p / about 50 mg No. 40, Abbott Gmbhyaponiya
  • Ganaton tbl p / about 50 mg No. 70, Abbott Gmbhyaponiya
  • Ganaton tbl p / about 50 mg No. 10, Abbott Gmbhyaponiya
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  • Ganaton of 50 mg No. 40 tabl.p.p.o. Abbott Dzhepeng Ko. Ltd. (Japan)
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Section: Gastrointestinal
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Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
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