Gatifloksatsin

Гатифлоксацин Drug photo

The description is actual on 02.08.2016

  • Latin name: Gatifloxacin
  • ATH code: J01MA16
  • Active ingredient: Gatifloksatsin (Gatifloxacin)
  • Producer: RUP of "Belmedpreparata" Republic of Belarus; Alkon Parenteralz (I) Ltd. (India)

Structure

In 1 ml of solution of a gatifloksatsin of 2 mg.

In 1 tablet of a gatifloksatsin of 200 or 400 mg. Cellulose microcrystallic, starch, calcium hydrophosphate, sodium propylparaben, sodium methylparaben, magnesium stearate, sodium krakhmalglikolit, talc, polyethyleneglycol-6000, a gidroksipropilmetiltsellyuloz, the titan dioxide, dibutyl phthalate.

Release form

Solution in a polyethylene bottle of 2 mg/ml on 400 ml and 200 ml.

Tablets in a cover of 200 mg and 400 mg.

Pharmacological action

Antibacterial.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug of a ftorkhinolonovy row IV of generation having antibacterial activity of a wide range: streptococci, staphylococcus, strains of Haemophillus, Neisseria gonorrhoeae, Klebsiella pneumoniae, an escherichia if, Moraxella catarrhalis, Enterobacter cloacae. Are rather sensitive to the drug Bordetella pertussis, Enterobacter aerogenes and agglomerans, Proteus mіrabilis and vulgaris, Morganella morganii, Bacteroides distasonis, eggerthiі and fragilis, Fusobacterium spp., Porphyromonas, Prevotella spp., clostridiums, C. pneumoniae, Ureaplasma, M. pneumoniae, Legionella pneumophila. Sensitive to it also tuberculosis mycobacteria.

Antibacterial action is connected with oppression of topoisomerase IV and DNK-girazy which is the important enzyme participating in reduplication of DNA of microorganisms. Topoisomerase — the enzyme which is important in division of chromosomes of DNA of a bacterial cell.

Pharmacokinetics

Bioavailability of active agent makes 96% at intake. Cmax in blood is defined in 1–2 hours. Slightly contacts proteins (20%). Well gets into fabrics and it is quickly distributed in liquids.

Especially high concentration are defined in a cover of bronchial tubes, pulmonary fabric, a middle ear, mucous adnexal bosoms, skin, a prostate gland, sperm, bile, an endometria, ovaries and uterine tubes. It biotransformirutsya minimum and allocated with urine where concentration its quite high. Elimination half-life of 7-14 hours. At a renal failure the dose of a gatifloksatsin needs to be reduced. The pharmacokinetics at persons till 18 flyings was not investigated.

Indications to use

Contraindications

  • intolerance and hypersensitivity;
  • age till 18 flyings;
  • pregnancy.

Side effects

With care to apply at increase in an interval of QT, hypercalcemia, bradycardia and a concomitant use of antiarrhytmic means, the expressed atherosclerosis of vessels of a brain, epilepsy, a renal failure. During administration of drug the speed of psychomotor reactions decreases that needs to be considered during the driving and work with dangerous mechanisms.

Gatifloksatsin, application instruction (Way and dosage)

Pill Gatifloksatsin is taken inside, it is not dependent on meal.

At the complicated bronchitis, infections of skin, pneumonia, acute pyelonephritis a dose for adults — 400 mg of times a day or 200 mg two times. A reception course till 10 days.

At acute sinusitis the dose and frequency rate of reception the same, but treatment can last 14 days.

At cystitis appoint 200 mg once a day, 3 days.

At uncomplicated gonorrhea — appoint Gatifloksatsin 400 mg of times a day.

At a renal failure patients need dose adjustment. At a single dose or reception within 3 days dose adjustment is not carried out. At administration of drug it is not necessary to take alcohol.

Solution of drug is intended only for intravenous infusions, lasting 60 minutes. It is necessary to avoid fast infusions. Enter 1 time a day. Unused solution is destroyed. Before introduction carry out an intracutaneous test. 5% solution of a dextrose, 0,9% of sodium of chloride, Ringer's solution of a lactate are compatible.

At an acute bronchitis, pneumonia, skin infections, acute pyelonephritis — 400 mg of 1 times a day 7 days. At cystitis — 400 mg once. At acute sinusitis — 400 mg a day 7–10 days. At a gonococcal urethritis and an endocervicitis — 400 mg once.

Overdose

Overdose is shown by slackness, vomiting, reduction of a respiration rate, a tremor and spasms. The gastric lavage and a symptomatic treatment is carried out.

Interaction

Probenitsid at simultaneous use increases concentration of active agent in blood.

Antacids, vitamins C microelements, and also zinc and ferrous sulfate reduce drug absorption.

Combined use with digoxin causes increase in concentration of the last.

Use with warfarin does not cause changes of time of coagulation. But, considering that drugs of this row strengthen effect of warfarin, it is necessary to control a prothrombin time.

The concomitant use with apo-Glyburidum patients with a diabetes mellitus does not influence distribution of drugs.

At a concomitant use of NPVS the risk of excitement of TsNS and convulsive reactions increases.

Terms of sale

It is released according to the recipe.

Storage conditions

Temperature is up to 25 °C. To protect from light.

Period of validity

2 years.

Gatifloksatsin's analogs

Gatispan, Zarkvin, Tebris, Tekvin.

About Gatifloksatsin

This drug is implemented in practice in 2001. It by 4 times exceeds activity of ciprofloxacin concerning steptokokk, stafilakokk, and enterococci and by 16 times concerning a kampilobakter and clostridiums. Bacteriological efficiency at negonokkokovy uretrita exceeds that a levofloksatsin. Concerning intracellular activators is more effective than azithromycin and a roksitromitsin. The broad spectrum of activity causes good effect at starting treatment of sepsis. Gatifloksatsin include treatment of tuberculosis, and also mikst-infections of an urogenital path in schemes.

Its efficiency is really high, but by results of researches drug is recognized toxic, and is removed from use in Europe and the USA since 2006. Gatifloksatsin's use can cause toxic action on heart which consists in emergence of arrhythmias and increase in an interval of QT, but the most frequent complication is a hyperglycemia or a hypoglycemia. Disturbances develop at patients with a diabetes mellitus more often, however cases also occur among the persons who do not have this disease. About side effects of drug it is reported in responses of patients.

  • "… The universal remedy, however has the big list of side effects. I, fortunately, did not have them".
  • "… The gynecologist a course of 10 days appointed. There was nausea from the second day and a diarrhea, but a course was completed nevertheless. However, the effect was".
  • "… Gatifloksatsin at a heavy purulent bronchitis accepted. Drug strong, helped me, but side effects much. There was candidosis stomatitis and a liquid chair. Another time would not accept it".
  • "… Saws this drug 2 weeks concerning chronic prostatitis. After that noticed vision disorders".

Apteka24

  • Gatifloksatsin solution for infusions 2ml/ml a bottle polyethylene 200 mlalkon Parenterals (India)

Paniapteka

  • Gatifloksatsin solution for inf. 2ml/ml p/et. fl. 200 ml
Section: Antibiotics
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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