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In 1 ml of solution of a gatifloksatsin of 2 mg.
In 1 tablet of a gatifloksatsin of 200 or 400 mg. Cellulose microcrystallic, starch, calcium hydrophosphate, sodium propylparaben, sodium methylparaben, magnesium stearate, sodium krakhmalglikolit, talc, polyethyleneglycol-6000, a gidroksipropilmetiltsellyuloz, the titan dioxide, dibutyl phthalate.
Solution in a polyethylene bottle of 2 mg/ml on 400 ml and 200 ml.
Tablets in a cover of 200 mg and 400 mg.
Pharmacodynamics and pharmacokinetics
The drug of a ftorkhinolonovy row IV of generation having antibacterial activity of a wide range: streptococci, staphylococcus, strains of Haemophillus, Neisseria gonorrhoeae, Klebsiella pneumoniae, an escherichia if, Moraxella catarrhalis, Enterobacter cloacae. Are rather sensitive to the drug Bordetella pertussis, Enterobacter aerogenes and agglomerans, Proteus mіrabilis and vulgaris, Morganella morganii, Bacteroides distasonis, eggerthiі and fragilis, Fusobacterium spp., Porphyromonas, Prevotella spp., clostridiums, C. pneumoniae, Ureaplasma, M. pneumoniae, Legionella pneumophila. Sensitive to it also tuberculosis mycobacteria.
Antibacterial action is connected with oppression of topoisomerase IV and DNK-girazy which is the important enzyme participating in reduplication of DNA of microorganisms. Topoisomerase — the enzyme which is important in division of chromosomes of DNA of a bacterial cell.
Bioavailability of active agent makes 96% at intake. Cmax in blood is defined in 1–2 hours. Slightly contacts proteins (20%). Well gets into fabrics and it is quickly distributed in liquids.
Especially high concentration are defined in a cover of bronchial tubes, pulmonary fabric, a middle ear, mucous adnexal bosoms, skin, a prostate gland, sperm, bile, an endometria, ovaries and uterine tubes. It biotransformirutsya minimum and allocated with urine where concentration its quite high. Elimination half-life of 7-14 hours. At a renal failure the dose of a gatifloksatsin needs to be reduced. The pharmacokinetics at persons till 18 flyings was not investigated.
Indications to use
- acute sinusitis;
- acute otitis;
- bronchitis, pneumonia, cystous fibrosis;
- infections of an urinary system (pyelonephritis, cystitis, prostatitis);
- infections of skin, bones and joints;
- postoperative complications;
- mikst-infection of an urogenital path at women;
- gonorrhea at men and women.
- intolerance and hypersensitivity;
- age till 18 flyings;
- fever, dorsodynia, perspiration;
- sleep disorder, sonitus, dizziness, paresthesias, vision disorders, tremor;
- tachycardia, arrhythmia;
- abdominal pain, vomiting, lock, nausea, oral cavity candidiasis, stomatitis;
- hamaturia, dysuric frustration;
- skin rashes;
- hyperglycemia, diabetes mellitus, hypoglycemia, diabetic ketoacidosis;
- peripheral hypostases.
With care to apply at increase in an interval of QT, hypercalcemia, bradycardia and a concomitant use of antiarrhytmic means, the expressed atherosclerosis of vessels of a brain, epilepsy, a renal failure. During administration of drug the speed of psychomotor reactions decreases that needs to be considered during the driving and work with dangerous mechanisms.
Gatifloksatsin, application instruction (Way and dosage)
Pill Gatifloksatsin is taken inside, it is not dependent on meal.
At acute sinusitis the dose and frequency rate of reception the same, but treatment can last 14 days.
At cystitis appoint 200 mg once a day, 3 days.
At uncomplicated gonorrhea — appoint Gatifloksatsin 400 mg of times a day.
At a renal failure patients need dose adjustment. At a single dose or reception within 3 days dose adjustment is not carried out. At administration of drug it is not necessary to take alcohol.
Solution of drug is intended only for intravenous infusions, lasting 60 minutes. It is necessary to avoid fast infusions. Enter 1 time a day. Unused solution is destroyed. Before introduction carry out an intracutaneous test. 5% solution of a dextrose, 0,9% of sodium of chloride, Ringer's solution of a lactate are compatible.
At an acute bronchitis, pneumonia, skin infections, acute pyelonephritis — 400 mg of 1 times a day 7 days. At cystitis — 400 mg once. At acute sinusitis — 400 mg a day 7–10 days. At a gonococcal urethritis and an endocervicitis — 400 mg once.
Overdose is shown by slackness, vomiting, reduction of a respiration rate, a tremor and spasms. The gastric lavage and a symptomatic treatment is carried out.
Probenitsid at simultaneous use increases concentration of active agent in blood.
Antacids, vitamins C microelements, and also zinc and ferrous sulfate reduce drug absorption.
Combined use with digoxin causes increase in concentration of the last.
Use with warfarin does not cause changes of time of coagulation. But, considering that drugs of this row strengthen effect of warfarin, it is necessary to control a prothrombin time.
The concomitant use with apo-Glyburidum patients with a diabetes mellitus does not influence distribution of drugs.
At a concomitant use of NPVS the risk of excitement of TsNS and convulsive reactions increases.
Terms of sale
It is released according to the recipe.
Temperature is up to 25 °C. To protect from light.
Period of validity
Coincidence on the ATH code of the 4th level:
Gatispan, Zarkvin, Tebris, Tekvin.
This drug is implemented in practice in 2001. It by 4 times exceeds activity of ciprofloxacin concerning steptokokk, stafilakokk, and enterococci and by 16 times concerning a kampilobakter and clostridiums. Bacteriological efficiency at negonokkokovy uretrita exceeds that a levofloksatsin. Concerning intracellular activators is more effective than azithromycin and a roksitromitsin. The broad spectrum of activity causes good effect at starting treatment of sepsis. Gatifloksatsin include treatment of tuberculosis, and also mikst-infections of an urogenital path in schemes.
Its efficiency is really high, but by results of researches drug is recognized toxic, and is removed from use in Europe and the USA since 2006. Gatifloksatsin's use can cause toxic action on heart which consists in emergence of arrhythmias and increase in an interval of QT, but the most frequent complication is a hyperglycemia or a hypoglycemia. Disturbances develop at patients with a diabetes mellitus more often, however cases also occur among the persons who do not have this disease. About side effects of drug it is reported in responses of patients.
- "… The universal remedy, however has the big list of side effects. I, fortunately, did not have them".
- "… The gynecologist a course of 10 days appointed. There was nausea from the second day and a diarrhea, but a course was completed nevertheless. However, the effect was".
- "… Gatifloksatsin at a heavy purulent bronchitis accepted. Drug strong, helped me, but side effects much. There was candidosis stomatitis and a liquid chair. Another time would not accept it".
- "… Saws this drug 2 weeks concerning chronic prostatitis. After that noticed vision disorders".
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