Hexamethylenetetramine

• Structure
• Release form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications to use
• Contraindications
• Side effects
• Hexamethylenetetramine, application instruction
• Overdose
• Interaction
• Terms of sale
• Storage conditions
• Period of validity
• Analogs
• Responses

Structure

Methenamin.

Release form

• Solution for in/in introductions (40%) in glass ampoules on 5 ml in cardboard packaging.
• Mg tablets 250, 500 in a glass flask No. 10.

Pharmacological action

Bactericidal, fungicidal, virulitsidny.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The antiseptic effect of drug is based on its property to emit formaldehyde which influences proteinaceous structures of microorganisms in acid medium, destroying them.

Pharmacokinetics

Completely and quickly it is also soaked up in a gastrointestinal tract. Practically does not contact proteins of plasma. Bioavailability — 30-60%. An elimination half-life — 4,3 hours. It is removed by kidneys within a day.

Indications to use

• Infectious diseases of urinary tract.
• Keratitis, iridocyclites.
• Cholangites and cholecystitises.
• Allergic skin diseases.
• Meningitis, arachnoiditis, encephalitis.

Contraindications

Hypersensitivity to drug, hepatonephric insufficiency, organism dehydration, pregnancy and the period of a lactation, age till 6 flyings.

Side effects

Nausea, pains in epigastric area, diarrhea, vomiting; defeat of a parenchyma of kidneys, hamaturia, crystalluria, albuminemia; allergic local reactions: reddening, skin rashes, morbidity and an itch in an injection site.

Hexamethylenetetramine, application instruction

The adult — hexamethylenetetramine solution (40%) intravenously 5-10 ml; in tablets 3-4 times a day on 0,5-1 g on reception, to children of 0,1-0,5 g.

Overdose

Perhaps in rare instances emergence of dysuric frustration and allergic reactions, and also, hamaturia, irritation of urinary tract.

Interaction

Drug in solutions is incompatible with alkaloid salts, acids, Pyramidon, tannins, caffeine, salicylates, salts of heavy metals, Resorcin, glucose, Salol. Loses activity at simultaneous use with streptocides.

Efficiency of Hexamethylenetetramine decreases at its joint appointment with the HP capable to alkalize urine (antiacid drugs, karboangidraza inhibitors, thiazide diuretics, hydrosodium carbonate).

Terms of sale

According to the recipe.

Storage conditions

In the dry place in tight packaging at a temperature not above 20 °C.

Period of validity

Hexamethylenetetramine ampoules — 5 years, tablets — 10 years.

Analogs

Analogs of Hexamethylenetetramine on the ATH code are Hexamin, Methenamin, Amiinoform, Metraminum, Urotropin, Cystogenum, Urisolum, Cystaminum, Formaminum.

Analogs on clinical action — Galenofillipt, 5-HOK, Diksin, Zivoks, Kirin, the Dioxidin, Kubitsin, Nitroxoline, Monural, Ristomycinum sulfate, Urofosfabol, Sangviritrin, the Eucalyptus tincture, Fosfomitsin, Zeniks, Linezolid-Teva, Amizolid.

About Hexamethylenetetramine

Responses are practically absent as in connection with emergence of more effective remedies, Hexamethylenetetramine has no broad use.