Гексамидин Drug photo

The description is actual on 29.07.2016

  • Latin name: Hexamidin
  • ATH code: N03AA03
  • Active ingredient: Primidonum (Primidone)
  • Producer: JSC Himiko-farmatsevtichesky QUINACRINE combine (Russia)


Primidonum, potato starch, glikolit sodium starch, erases calcium, polyvinylpirrolidone.

Release form

Mg tablets 125 and 250 ploskotsilindrichesky white color in planimetric packaging in a cardboard pack No. 10, 20, 50.

Pharmacological action


Pharmacodynamics and pharmacokinetics


Drug reduces excitability of neurons in the epileptogenic center of a brain, reduces quantity of big epileptic seizures, possesses weak somnolent action. The chemical structure of drug is close to phenobarbital, but it renders more expressed anticonvulsant effect, at the same time, has no the systemic oppressing effect on TsNS.


Drug is completely and quickly absorbed from a gastrointestinal tract. Cmax is reached in 2 hours. Bioavailability of drug more than 90%. Primidonum biotransformirutsya in a liver therefore it is formed 2 pharmacological active a metabolite: feniletilmalonamid and phenobarbital. Primidonum and derivative metabolites are allocated with breast milk. It is removed with urine.

Indications to use

Treatment of epilepsy of various genesis with mainly big convulsive attacks.


High sensitivity to drug, kidneys/liver diseases, a leukopenia, anemia, pregnancy, a lactation.

To take with caution to persons of advanced and children's age because of high risk of motive and paradoxical excitement.

Side effects

Headache, drowsiness, uneasiness, dizziness, apathy, psychotic reactions, ataxy, vomiting, nausea, leukopenia, B12 - scarce anemia, an arthralgia, allergic reactions. At long reception — development of medicinal dependence.

Hexamidine, application instruction (Way and dosage)

To accept after food, once in a single dose of 125 mg, then the daily dose is increased by each 3 days by 250 mg - for adults and by 125 mg to children till 9 flyings. To accept before achievement of therapeutic effect. For adults the maximum daily dose makes 1,5 g (in 2 receptions), for children — 1 g.


TsNS function oppression, ataxy, nausea, dizziness.


Drug accelerates a metabolism and weakens pharmacological effect of paracetamol, indirect anticoagulants, GKS, tricyclic antidepressants, glycosides of a foxglove, caffeine, chloramphenicol, cyclosporine, Disopyramidum, doxycycline, a dakarbazin, left thyroxine, a meksiletin, metronidazole, quinidine, vitamin D, the phenopro-hair dryer, Aminophyllinum, theophylline, an okstrifillin.

At joint reception with the alcohol, drugs possessing the central depriving of bonuses action strengthens oppression of TsNS. Strengthens action of HP with somnolent action, a derivative methotrexate, cyclophosphamide, a sulfonilmochevina, and also toxic action on a liver of group of the drugs used for the general anesthesia (a metoksifluran, a halothane, an enfluran). At joint reception with karboangidraza inhibitors high risk of disturbance of processes of bone formation. Drug reduces antifungal activity of griseofulvin.

Methylphenidate oppresses processes of a metabolism of Primidonum. Leykovorin weakens anticonvulsant effect of drug. At joint reception with Phenylbutazone — the pharmacological effect of two drugs is mutually weakened. Myelotoxic drugs strengthen Primidonum gematotoksichnost. At joint reception with the drugs stimulating microsomal enzymatic activity of a liver: rifampicin, phenobarbital, ethanol (at the long use), carbamazepine, the metabolism of Primidonum accelerates and decreases its pharmacological efficiency.

Terms of sale

According to the recipe.

Conditions hraneniyamilepsin

Period of validity

60 months.

Analogs of the Hexamidine

Coincidence on the ATH code of the 4th level:

Primidonum, Misolynum, Mizolin, Primaklon, Sertanum, Dezoksifenobarbiton, Lepidine, Lespiral, Liskantinum, Mizodinum, Mylepsinum, Prilepsinum, Primolinum, Prysolinum, Sedilenum and others.

About the Hexamidine

According to doctors the Hexamidine is an effective antikonvulsant, especially in cases of generalized toniko-clonic convulsive attacks. Drug can be used, both as mono means, and in a complex with other HP (dipheninum, phenobarbital, clonazepam).


  • Hexamidine of 250 mg No. 50 of a tablet
to show still
Section: For a nervous system
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use the Hexamidine surely consult with the attending physician.