Haemoferum

Гемофер Drug photo

The description is actual on 16.03.2016

  • Latin name: Hemofer
  • ATH code: B03AA05
  • Active ingredient: Gland chloride (drops), Gland sulfate (dragee)
  • Producer: Medana Pharma TERPOL Group J.S., Co. (Poland), GlaxoSmithKline Pharmaceuticals (Poland)

Structure

  • In 1 ml of drops of ferric chloride (II) of 157 mg.
  • In 1 dragee of ferrous sulfate of 325 mg. Lactoses monohydrate, ammonium methacrylate, talc, magnesium stearate as excipients.

Release form

  • Drops in a bottle on 10 ml and 30 ml.
  • Dragee of 325 mg No. 30.

Pharmacological action

Antianemic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The antianemic drug containing iron in the form of bivalent salt, applied to treatment of iron deficiency states. Iron is a part of hemoglobin, a myoglobin and enzymes, plays a large role in tissue respiration. The part of the arrived iron is spent for synthesis in an organism of ferriferous connections, and other — is deposited in a liver and a spleen. The need for it makes 3 mg/days. Drug fills the existing shortage of iron and stimulates hemoglobin synthesis. Effects of its action at anemias are noted in 10 days, but reserves of iron are recovered in 3 months of regular reception.

Pharmacokinetics

It is soaked up in a small intestine, generally a duodenum. Extent of absorption depends on deficit of iron – the it is higher, the absorption is better. At essential deficit absorption of 10-30% (at normal content no more than 15%). In process of normalization of its level, in a gastrointestinal tract the amount of assimilable iron decreases. Also absorption depends on the valency of iron and acidity of a gastric juice. The drugs Fe2 + are easily soaked up in a small intestine. It joins in composition of hemoglobin in marrow.

Indications to use

All dosage forms of drug are applied to treatment:

  • posthemorrhagic anemia (operations, childbirth, profuse bleedings);
  • iron deficiency anemia;
  • deficit of iron.

For the purpose of prevention:

  • at pregnancy and a lactation;
  • in a growth period of children;
  • at newborns from polycarpous pregnancy;
  • at premature newborns;
  • at adults (donorship, vegetarianism).

Contraindications

  • hypersensitivity;
  • hemosiderosis, hemochromatosis;
  • aplastic and hemolitic anemias;
  • disturbance of digestion of iron;
  • gastrointestinal tract dysfunctions which interfere with iron absorption.

With care drug is appointed at a peptic ulcer, ulcer colitis and enteritis.

Side effects

  • dizziness, headache;
  • feeling of a prelum behind a breast;
  • abdominal pains, weight in epigastric area, nausea, frustration of a chair or a lock;
  • allergic reactions;
  • hyperemia of the person, weakness, indisposition.

Haemoferum, application instruction (Way and dosage)

Drops accept inside between meals, diluting with water or juice. At emergence of side reactions drug is accepted during food. The daily dose can be divided into several receptions. Calculation of a dose: for children of 3 mg/kg a day, for adults – 200 mg a day. In 1 ml 44 mg of iron, in 1 drop of 1,6 mg of iron.

At anemias treatment is carried out it is long – 3 - 5 months. In case of the expressed deficit of iron hemoglobin is normalized in 2-3 months. However, for recovery of reserves of iron administration of drug is continued in preventive doses by several months.

To premature children appoint 1 drop a day.

To children till 1 year: 10-19 drops, from 1 year to 12 flyings – 28 drops a day, the adult – 55 drops 2 times a day.

Half doses are applied to prevention.

Drug can paint enamel of teeth not to allow it it is necessary to accept it through a straw.

Haemoferum prolongatum in the form of a dragee is accepted on an empty stomach or between meals. Reception right after food is possible. For the purpose of prevention adults and children since 12 accept 1 dragee once a day. At anemia — on 1 dragee 2 times a day. Treatment lasts from 2 weeks to 5 months. All dosage forms of iron paint a chair in dark color.

Overdose

Overdose is shown by nausea, vomiting, the diarrhea, abdominal pains which is speeded up by pulse, increase of arterial pressure, a hyperpermeability of capillaries, a collapse.

At poisoning with high doses there is a bloody diarrhea, perforation of intestines and bleeding is possible.

Treatment is begun with a gastric lavage, purpose of purgatives, then Deferoxaminum which connects iron is entered.

Interaction

Antiacid drugs somewhat reduce iron absorption.

The food, in particular eggs, milk and dairy products, reduce drug absorption. Ascorbic acid increases its absorption.

Drug reduces efficiency of hinolon, Levotiroksin, Levodofy, Methyldopas, Penicillin, tetracyclines, Sulfasalazinum, zinc salts.

Colloid bismuth citrate, chloramphenicol, kolestipol, holestiramin, tetracyclines, Pancreatinum reduce efficiency of this drug. Vitamin E reduces its action.

It is necessary to avoid joint appointment with Allopyrinolum.

Terms of sale

According to the recipe.

Storage conditions

At a temperature of 15-25 Pages.

Period of validity

  • Drops 2 years.
  • Tablets Haemoferum (Dragee) 3 years.

Analogs

Coincidence on the ATH code of the 4th level:

Aktiferrin, Sorbifer Durules, Tardiferon, Ferro-Folgamma, Fumarates gland, Ferroplexum, Ferrogradumet, the Totem, Ferronat.

About Haemoferum

Ferrous sulfate is "the gold standard" of peroral iron preparations. It has high absorbability which is much higher, than Fumarat or the Gluconate have gland. According to patients very much had to accept this drug – most often it is pregnant women and women who suffer from an iron deficiency anemia. As a rule, treatment was begun with drugs for intake, and in rare instances (bad portability, absorption disturbance, a state after a resection of a small intestine) were appointed intramusculary.

Adults accepted drug in a dragee or drops, and to children it was appointed only in the form of drops. At treatment at all children in 6 — 10 weeks hemoglobin level was normalized. At anemia of easy degree treatment duration Haemoferum made 6 weeks, moderately severe – 8 weeks, and at heavy anemia of 10 weeks. Preventive reception in a half dose for 1-1,5 months was recommended to all. All noticed efficiency of treatment in 7–10 days: weakness, fatigue, perspiration, dizziness disappeared.

By-effects forced many patients to refuse administration of drug. At its use there is an irritation mucous a stomach (there is a dissolution) and a duodenum where there is an absorption. At many nausea, stomach aches, frustration of a chair were noted.

To minimize by-effects from a gastrointestinal tract, it is better to begin treatment with 1/4 for a necessary dose and gradually within 7 days to bring to a full dose. Reduces a drug irritant action on a gastrointestinal tract its reception after food.

Zdravzona

  • Haemoferum prolongatum dragee No. 30
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Apteka24

  • Gemoferon solution for oral administration 200mlsperko (Ukraine, Vinnytsia)

Paniapteka

  • Gemoferon solution for peror. comment of 200 ml

BIOSPHERE

  • Haemoferum prolongatum 325 mg No. 30 drazheglaxo Wellcome Poznan (Poland)
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Section: For blood
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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