Genferon

Генферон Drug photo

The description is actual on 14.05.2014

  • Latin name: Genferone
  • ATH code: L03AB05
  • Active ingredient: Interferon human recombinant alpha 2b (Interferon alfa-2b)
  • Producer: JSC BIOCAD, Russian Federation

Structure

1 candle (suppository) contains: interferon recombinant human alpha 2b – 500000 ME or 1000000 ME (depending on a dosage), taurine – 10,0 mg, benzocaine – 55,0 mg.

Excipients: a macrogoal 1500, a dextran 60000, polysorbate 80, citric acid, T2 emulsifier, sodium hydrocitrate, solid fat, the water purified.

Release form

Candles of white or light yellow color. Have the cylindrical form, the pointed termination, on longitudinal section homogeneous, but existence of air inclusions is allowed.

1 or 2 planimetric packagings containing 5 suppositories are issued in cardboard packs, in one such pack.

Pharmacological action

Genferon possesses the immunomodulatory, anti-proliferative, antibacterial, antiviral, mestnoanesteziruyushchy, regenerating action.

Pharmacodynamics and pharmacokinetics

The combined Genferon's action is caused by components in his structure which have local and systemic effect.

As a part of Genferon there is a human recombinant interferon alpha 2b. It is synthesized by genetically engineered modified Escherichia coli microorganism strain.

Interferon alpha 2b is an immunomodulator, and also has anti-proliferative, anti-virus and antibacterial effect. These effects are caused by a promoting effect of drug on desmoenzymes which inhibit reproduction of a virus. Interferon increases cellular immunity by means of activation of a number of markers of cells killers, acceleration of division of B-lymphocytes and synthesis of antibodies by them, increases in activity of monocytic and macrophagic system and increase of recognizability of the infected and tumor cells. As a result of it efficiency of fight of an organism against viruses, bacteria, parasites and cancer cells increases. Also under the influence of interferon there is an activation of leukocytes of a mucous membrane which participate in suppression of the pathological centers.

Taurine normalizes metabolic processes in fabrics, promotes their regeneration, interacts with free radicals of oxygen, neutralizing them and protecting fabrics from damage. Interferon is less subject to disintegration and longer keeps the action thanks to taurine presence.

Benzocaine (anaesthesin) – a local anesthetic. It changes permeability of cytoplasm of neurons for ions of sodium and calcium therefore not only carrying out nervous impulses on axons is blocked, but also process of emergence of nervous impulses is inhibited. Benzocaine has only local effect and is not soaked up in a system blood stream.

At rectal use of Genferon bioavailability reaches more than 80%. It allows to reach both the local, and expressed immunomodulatory action in scales of all organism. At vaginal use, thanks to big concentration of drug in the center of an infection and its fixing on cells mucous, the noticeable local antiviral, antibacterial and anti-proliferative effect, however in this case system effect is reached (because of the small adsorbing ability of mucous internal generative organs) it is insignificant. The maximum concentration of interferon in blood comes to light in 4-6 hours after drug use. It is removed generally by kidneys. The elimination half-life is equal to 12 hours that causes the necessity to use drug 2 times a day.

Indications to use

Indications to use of candles Genferon means rectal or vaginal (in dosages of 500 thousand ME or 1 million ME) their use from what in treatment of the corresponding uncomplicated diseases at children the children's candles (Genferon Layt) of the same name, and also their analogs in different forms are used (for example ointment, syrup or tablets).

In other cases Genferon is used in complex treatment at diseases of urinogenital system of infectious and inflammatory character at adults:

Use of drug at the milkwoman (vaginal candidiasis) is also proved.

Contraindications

Hypersensitivity to the interferon or other substances which are in composition of drug is contraindication to its use. Treatment by drug inadmissibly in the first 12 weeks of pregnancy. Also with care it is necessary to apply Genferon at patients with exacerbations of diseases of immune system.

Side effects

At treatment by drug in a dose 10000000 ME in days and more the possibility of development of the following side effects raises:

  • headache – from the central nervous system;
  • leukopenia, thrombocytopenia – from system of a hemopoiesis;
  • system reactions (hyperthermia, increase in sweating, increase of fatigue, muscle and joints pain, deterioration in appetite).

Emergence of allergic reactions is possible: skin rash, itch. These symptoms are reversible and pass within 72 hours after the termination of administration of drug.

The instruction on candles Genferon

The application instruction of Genferon explains that duration of a course of treatment, the dosage and a way of introduction are defined by the attending physician and depend on a specific disease. The application instruction of candles Genferon and the instruction on children's Genferon are almost identical the offered schemes of use of drug. However children not always suit a rectal or vaginal way of administration of drug therefore in some cases it is worth thinking of transition to Genferon's analogs with other ways of introduction (a tablet, ointment, syrup).

Drug is used vaginalno or rektalno.

At treatment of diseases of urinogenital system of infectious and inflammatory character at women about 1 candle is recommended to enter (500000 ME or 1000000 ME, depends on a disease form) vaginalno or rektalno (depends on a disease form) 2 day a day within 10 days. At long and chronic forms introduction every other day on 1 candle is possible. In this case the course of treatment will make from 1 to 3 months.

Use of 1 suppository (500000 ME) vnutrivlagalishchno in the morning and 1 suppository (1000000 ME) rektalno in the evening along with intra vulval use of antibacterial suppositories is proved at serious infectious and inflammatory process in internal generative organs.

Treatment of diseases of an urogenital path of infectious and inflammatory character at men is reduced to the following scheme of treatment: rektalno about 1 candle (the dosage depends on a disease form) 2 times a day within 10 days is applied.

Overdose

There are no data on cases of overdose by Genferon so far. If the large number of candles was accidentally at the same time entered, it is necessary to stop use of drug for days. After the specified time it is possible to start over again Genferon's use according to the appointed scheme.

Interaction

Vitamins C and E strengthen action of components of Genferon. Benzocaine reduces bactericidal and bacteriostatic activity of streptocides. Non-narcotic analgesics often strengthen effect of benzocaine.

Terms of sale

In Russia and in Ukraine Genferon it is possible to buy in a drugstore only according to the recipe.

Storage conditions

Drug needs to be stored in the dark place, unavailable to children, in the range of temperatures of 2 - 8 °C.

Period of validity

Period of validity — 24 months. Use of drug after expiry date is not recommended (it is specified on packaging).

Special instructions

Genferon is most effective at simultaneous use with antimicrobic medicines.

About safety of use of drug at monthly there are no reliable data. Therefore it is necessary to use with care drug during monthly.

Genferon's analogs

At once It should be noted that often the analogs provided in our drugstores are cheaper than Genferon and in most cases reasonable price of analogs is connected with their Ukrainian origin.

So, than it is possible to replace candles Genferon:

  • full analogs on active ingredient and a form of release – Vitaferon, Viferon, Viferon-Feron, Laferobion, Laferon Farmbiotek, Kipferon;
  • analogs on active ingredient – Alfarekin, Alfarona, Bioferon, Virogel, Gerpferon, Grippferon, Introbion interferon alpha 2b, the Intron And, Interoferobion interferon alpha 2b, Laferon Farmbiotek, Lipoferon, Okoferon, Realdiron and others.

Zdravzona

  • Genferon of 1 million ME No. 10 suppozitoriibiokad closed joint stock company
  • Genferon of 500 thousand ME No. 10 suppozitoriibiokad closed joint stock company
  • Genferon of light 250 thousand ME No. 10 suppozitoriibiokad closed joint stock company
  • Genferon of light 125 thousand ME No. 10 suppozitoriibiokad closed joint stock company
  • Genferon light spray nasal 50000ME +1mg/dose 100 doses with raspylitelembiokad closed joint stock company

Drugstore of IFC

  • Genferon soup. vaginas / rekt. 500 thousand ME No. 10, Biokad Zaorossiya
  • Genferon light soup. vaginas / рект.250тыс. No. 10 ME, Biokad Zaorossiya
  • Genferon soup. vaginas / rekt. 1000000 ME No. 10, Biokad Zaorossiya
  • Genferon light soup. vaginas / рект.125тыс. No. 10 ME, Biokad Zaorossiya
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Apteka24

  • Genferon Light spray naz. 50000 100dozbiokad (Russia)
  • Genferon Layt of IB soup. 125000ME No. 10biokard (Russia)
  • Genferonbiokad (Russia, Moscow)

BIOSPHERE

  • ÂÑ¡õÑÓ«¡® 1000000 ME No. 10 soup. Bioring road of closed joint stock company (Russia)
  • ÂÑ¡õÑÓ«¡® 500000 ME No. 10 soup. Bioring road of closed joint stock company (Russia)
  • Генферон® Light 125000 ME No. 10 soup. Bioring road of closed joint stock company (Russia)
  • Генферон® Light 250000 ME No. 10 soup. Bioring road of closed joint stock company (Russia)
  • Генферон® Light 50000 ME/dose of 100 doses spreybiokad closed joint stock company (Russia)
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Section: Gynecologic Immunity increase Antiviral Urological
in more detail

Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Genferon surely consult with the attending physician.