Gentamycin

Гентамицин Drug photo

The description is actual on 09.06.2016

  • Latin name: Gentamicin
  • ATH code: S01AA11
  • Active ingredient: Gentamycin (Gentamicin)
  • Producer: Belmedpreparata of RUP (Republic of Belarus), Warsaw Pharmaceutical Works Polfa (Poland), Moscow endocrine plant, NIZHPHARM, Synthesis of joint stock company, Mikrogen of NPO Federal State Unitary Enterprise, Pharmstandard-UFAVITA (Russia), etc.

Structure

As a part of solution for introduction intravenously and intramusculary active component Gentamycini sulfas, and also a number of additional components contains: sodium metabisulphite, salt disodium ethylene diamine tetraacetic acid, water.

Drops eye contain in structure active component Gentamycini sulfas, and also additional components: dihydrophosphate sodium monohydrate, sodium chloride, hydrophosphate sodium dodecahydrate, solution benzalkoniya chloride, water.

Form of production of Gentamycin

Drug in several forms is made:

  • powder for preparation of solution which contains in bottles;
  • solution of 4% in ampoules (ampoules on 1 and 2 ml) – the colourless or a little painted transparent liquid;
  • drops eye 0,3% in tubes droppers;
  • ointment for outside use;
  • aerosol Gentamycin.

Gentamycin in tablets are not made.

Pharmacological action

Gentamycin is the antibiotic showing a wide range of influence, belongs to group of aminoglycosides. In an organism communicates with 30S in subunit of ribosomes owing to what there is a disturbance of synthesis of protein, products of a complex of transport and information RNA stop. Wrong reading of RNA is noted and nonfunctional proteins are formed. Bactericidal influence is observed – on condition of high concentration of substance reduces barrier functions of cytoplasmic membranes owing to what microorganisms perish.

High sensitivity to this antibiotic from some gram-negative microorganisms is noted.

Sensitivity to substance of a number of gram-positive microorganisms is also noted.

Resistance to an antibiotic is shown: Neisseria meningitidis, Providencia rettgeri, Clostridium spp., Treponema pallidum, Bacteroides spp., Streptococcus spp.

If Gentamycin is combined with penicillin, activity in relation to Enterococcus faecium, Enterococcus faecalis, Enterococcus avium, Enterococcus durans, Streptococcus faecium, Streptococcus durans, Streptococcus faecalis is noted it.

Stability of microorganisms to this drug develops slowly, but those strains which show resistance to Neomycinum and Kanamycinum, can also be steady against gentamycin influence. On mushrooms, the elementary, viruses does not work.

Pharmacokinetics and pharmacodynamics

After introduction intramusculary there is a fast and full absorption of substance. The maximum concentration in an organism after introduction is intramusculary reached 0.5-1.5 hours later. After carrying out 30-minute infusion intravenously – in 30 min., after 60-minute infusion intravenously – in 15 min.

Contacts proteins of plasma a little — to 10%. Therapeutic concentration of substance are found in kidneys, a liver, lungs, and also in organism liquids — peritoneal, ascitic, synovial, pericardiac, pleural, lymphatic; it is found in the pus separated by wounds, granulations in urine.

Low concentration of substance are observed in muscles, fatty tissue, breast milk, bile, bones, a phlegm, a secret of bronchial tubes, cerebrospinal fluid, eye moisture.

Through GEB at adult patients almost does not get, through a placenta gets.

In cerebrospinal fluid at newborns of concentration is higher, than at adults.

Is not exposed to a metabolism in an organism. Semi-removal time at adults is equal 2-4 hours, children till 6 months have 3-3.5 hours.

Out of an organism it is generally brought through kidneys, in not changed look, insignificant quantities of an antibiotic are output with bile. If functions of kidneys at the patient normal, then for the first days 70-95% of substance are removed. At the same time in urine concentration more than 100 mkg/ml is noted. Cumulation at repeated introduction is noted.

Indications to use

Indications to use of means — diseases of infectious and inflammatory character which were provoked by the microorganisms sensitive to gentamycin.

Parenteral use of medicine (solution of 4%) is shown at such diseases:

  • pyelonephritis;
  • acute cholecystitis;
  • cholangitis;
  • cystitis;
  • pneumonia;
  • peritonitis;
  • pleura empyema;
  • ventrikulit;
  • sepsis, purulent defeats of soft tissues and skin;
  • infections owing to wounds and burns;
  • infections of joints and bones.

Pricks in gynecology are applied at heavy inflammatory processes.

External use of medicine (ointment Gentamycin) is shown at such diseases:

  • the folliculitis is superficial;
  • pyoderma;
  • furunculosis;
  • the seborrheal dermatitis infected;
  • paronychias;
  • sycosis;
  • acne infected;
  • manifestation of secondary bacterial infection in case of viral and fungus diseases of integuments;
  • wounds of a different origin (stings, burns, ulcers, etc.);
  • the varicose ulcers infected.

Topical administration of Gentamycin (a drop eye) is reasonable at such diseases:

  • blefarokonjyunktivit;
  • blepharitis;
  • conjunctivitis;
  • meibomitis;
  • keratitis;
  • keratoconjunctivitis;
  • dacryocystitis.

Contraindications

It is not necessary to apply this medicine in such cases:

  • high sensitivity to this antibiotic and other aminoglycosides;
  • neuritis of an acoustical nerve;
  • uraemia;
  • renal failures in a severe form;
  • pregnancy and feeding.

In the course of use of this medicine it is necessary to control function of kidneys periodically.

Side effects

In the course of reception certain side effects can be noted:

  • system of digestion: hyperbilirubinemia, nausea and vomiting, growth of activity of "hepatic" transaminases;
  • hemopoiesis: leukopenia, anemia, thrombocytopenia, granulocytopenia;
  • nervous system: paresthesias, headache, twitching of muscles, feeling of numbness, epileptic seizures, drowsiness; display of psychosis at children is possible;
  • sense bodys: sonitus, deterioration in hearing, labyrinth and vestibular disturbances, deafness;
  • urination: nephrotoxicity with a renal failure, it is rare — a renal tubular necrosis;
  • allergies: rash on skin, fever, an itch, an eosinophilia, a Quincke's disease;
  • laboratory indicators: a hypopotassemia, a hypocalcemia, a hypomagnesiemia – at children;
  • other manifestations: superinfection.

Application instruction of Gentamycin (Way and dosage)

It is necessary to apply Gentamycini sulfas, considering localization of an infection, weight of an illness, sensitivity of the activator.

Gentamycin pricks, application instruction

Before an initiation of treatment it is recommended to carry out determination of sensitivity of microflora to gentamycin.

Drug in ampoules at introduction intravenously or intramusculary is shown to adults in a dose — 1.7 mg on weight kg. The dose in days is equal to 3-5 mg on weight kg. It is necessary to enter medicine 2-4 times a day. Treatment continues from 7 to 10 days. For intramuscular introduction also use powder, previously adding 2 ml of the water distilled to an ampoule.

Gentamycin, depending on an illness, can be also applied in a dose of 120-160 mg for 7-10 days or in a dose of 240-280 mg once once a day.

Introduction is intravenously practiced for 1-2 h.

To children appoint this medicine only at serious infectious diseases. Newborn children and premature babies receive in days a dose at the rate of 2-5 mg on kg, administer the drug twice a day.

Children till 2 flyings receive the same dose in days, the drug is administered by three times a day.

Children after 2 flyings receive in days a dose at the rate of 3-5 mg on kg, the drug is administered by three times a day.

Patients with renal failures need to adjust a dose.

The maximum dose in days for children and adults makes 5 mg on weight kg.

Ointment Gentamycin, application instruction

Outwardly it is necessary to apply ointment Gentamitsin Akos 3-4 times a day. Before drawing it is necessary to remove the necrotic masses and pus carefully. If defeats are extensive, then the ointment dose in days should not exceed 200 g. Duration of treatment is established by the doctor.

It is necessary to dig in eye drops on 1-2 drops each 1-4 hours in the lower conjunctival sac. The patient with a keratitis, conjunctivitis and other infectious and inflammatory diseases of eyes recommends to drip three times a day 0,3% Gentamycin solution.

Means in tablets is not made.

Overdose

At overdose of Gentamycin in ampoules or other forms of medicine lowering of neuromuscular conductivity up to an apnoea can be noted.

At overdose adult patients need to enter antikholinesterazny medicine (Prozerin), calcium drugs. Before introduction of a prozerin to the patient enter 0,5–0,7 mg of Atropine intravenously, expect until pulse becomes frequent then enter prozerin in a dose 1,5 mg. If there is no effect after introduction of such dose, as much the prozerin is entered repeatedly. At development of bradycardia give an additional injection of atropine.

At overdose at children administration of drugs of potassium is necessary. Gentamycini sulfas is brought out of an organism by a hemodialysis and a peritoneal dialysis.

Interaction

If pricks of Gentamycin or use of other forms of medicine practice along with Vancomycinum, aminoglycosides, cephalosporins, Acidum etacrynicum, can amplify from - and nephrotoxic influence.

If means is applied with Indometacin, then the clearance of Gentamycin decreases, its concentration increases in blood and, respectively, toxic influence increases.

At use of Gentamycin with opioid analgetics, drugs for an inhalation anesthesia the probability of neuromuscular blockade increases, development of an apnoea is possible.

Concentration of gentamycin in blood increases if to accept it along with "loopback" diuretics.

Terms of sale

It is possible to buy in a drugstore according to the recipe, the doctor writes out the recipe on Latin.

Storage conditions

To protect from light, to store Gentamycin at a temperature up to 25 °C.

Period of validity

It is possible to store 4 years.

Special instructions

It is carefully necessary to apply this medicine to people who suffer from a myasthenia, parkinsonism, renal failures. At people with an impaired renal function, and also at long reception of high doses of means the risk of manifestation of nephrotoxicity increases. In the course of treatment it is important to control a condition of vestibular and acoustical devices, function of kidneys. It is also important to define a condition of hearing. If audiometric tests are unsatisfactory, stop treatment.

It is necessary to consider that at long use of means outwardly perhaps resorptive action from what ointment Gentamitsin Akos, etc. medicine forms outwardly should be applied is controlled.

In view of existence as a part of solution the probability of development of allergic manifestations, especially at people with the allergological anamnesis increases in ampoules of sodium of bisulphite.

It is recommended to people who take medicine for therapy of infectious and inflammatory diseases of urinary tract to drink a lot of liquid in the course of treatment.

In the course of therapy development resistance of microorganisms is possible.

Analogs

Coincidence on the ATH code of the 4th level:

In drugstores numerous analogs of Gentamycin are offered. These are the drugs Garamycinum, Gentamitsin Akos, Gentamitsin-Tev, Gentamycin K, Asgent, Septopa, Gentatsikol, etc. Indications and contraindications at analogs practically same, but the final choice of medicine the doctor has to carry out. There is also a number of drugs which active agents are Betamethasone + Gentamycin + Clotrimazolum.

Zdravzona

  • Gentamycini sulfas of 4% solution for injections of 2 ml No. 10 ampulymikrogen NPO Federal State Unitary Enterprise
  • Gentamitsinovy ointment of 0,1% 15gnizhfarm joint stock company
  • Gentamycin-to 40 of mg of 1 ml No. 10 amp.krka
  • Deksa-gentamitsin oculentum 2,5gursafarm Artsnaymittel Gmbh
  • Deksa-gentamitsin drops eye 5 ml bottle-kapelnitsaursafarm Artsnaymittel Gmbh

Drugstore of IFC

  • Deksa-Gentamitsin hl drops. 5 ml, Ursapharm Arzneimittel Gmbhgermaniya
  • Gentamycini sulfas solution for in 4% 2 ml No. 10, Mikrogen of NPO Federal State Unitary Enterprise (Virion of NGO Tomsk) Russia
  • Gentamycin ointment of 0.1% 15 g, Synthesis of AKO of joint stock company (Kurgan) Russia
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Apteka24

  • Gentamitsingalichfarm (Ukraine, Lviv)
  • Gentamitsindarnitsa (Ukraine, Kiev)
  • Gentamitsinzdorovye (Ukraine, Kharkiv)
  • Deksa-gentamitsin eye drops 5mlursafarm (Germany)

Paniapteka

  • Gentamycini sulfas solution for infection. 4% of amp. 2 ml No. 10darnitsa
  • Gentamycini sulfas solution for infection. 4% of amp. 2 ml No. 10darnitsa
  • Gentamycini sulfas solution for infection. 4% of amp. 2 ml No. 10darnitsa

BIOSPHERE

  • Gentamycini sulfas of 4%/2 ml No. 10 solution for in.amp. Borisovsky ZMP (Belarus)
  • Gentamycini sulfas of 4%/2 ml No. 10 solution for in.amp.
  • Gentamycini sulfas of 4%/2 ml No. 10 solution for in.amp. Dosfarm (Kazakhstan) LLP
  • Gentamycini sulfas of 4%/2 ml No. 10 solution for in.amp. Health - the pharmaceutical company (Ukraine)
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Section: Antibiotics
in more detail

Education: "Pharmacy" graduated from the Rovno state basic medical college majoring in. Graduated from the Vinnytsia state medical university of M. I. Pirogov and internship on its base.

Experience: From 2003 to 2013 – worked at positions of the pharmacist and manager of a pharmaceutical booth. It is awarded by diplomas and distinctions for long-term and honest work. Articles on medical subject were published in local editions (newspaper) and on various Internet portals.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Gentamycin surely consult with the attending physician.