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Main components: ferrous sulfate (II) and folic acid. Each tablet of the prolonged action contains 256,3 mg of iron in the form of sulfate that corresponds to 80 mg of pure iron, and 350 mkg of folic acid.
Additional components: dibutyl phthalate, ascorbic acid, stearate magnesium, castor oil, talc, anhydrous mukoproteoza.
The cover consists of beeswax, dioxide of titanium.
Gino-Tardiferon is issued in the tableted look. Tablets have the biconvex form. The special cover provides the long, prolonged action of a medicine with slower release of active components. In packaging of 30 pieces.
The combined hemogenesis stimulator, antianemic medicine.
Ferrous sulfate is iron salt which is directly involved in hemoglobin synthesizing process. Iron contains in a myoglobin, enzymes and the hemoglobin. Reception of salts of iron allows to fill their shortcoming quickly enough. At deficit of iron dryness of integuments, a cardiopalmus, fast fatigue, dizzinesses, the expressed weakness is noted.
Folic acid takes part in formation of normoblasts, maturing of megaloblasts, a choline exchange, synthesis of nucleic acids, amino acids, pyrimidines and purines. At pregnancy incubation folic acid protects from influence of teratogens, promoting normal laying of bodies and fetation.
To Mukoproteaz receive from intestines of animals, it is high-molecular fraction of a natural origin. Mukoproteaza is capable to increase biological availability of ions of iron. Ascorbic acid stimulates iron absorption.
The neutral cover of tablets provides gradual absorption of the operating components in a small intestine, protecting mucous walls of a stomach from the irritating influence and preventing undesirable side effects from a digestive tract.
Pharmacodynamics and pharmacokinetics
Biological availability of iron reaches 10-30%. In distal part of a small intestine slow absorption of active components is carried out. Folic acid begins to be soaked up in a duodenum. Plasma proteins contact iron for 90%. Deposition happens in the form of hemosiderin and ferritin, the part settles in muscular tissue in the form of a myoglobin. Iron is removed then, urine and a stake.
Folic acid contacts plasma proteins for 64%. Biological transformation happens in hepatic system. Folic acid is removed by renal system, partially through intestines.
Indications to use
Completion of a lack of iron of an organism at:
- plentiful bleedings;
- unbalanced food;
- disturbance of absorption of iron in a digestive tract.
- hemosiderosis (surplus of Fe in an organism);
- obstruction of a gastrointestinal tract;
- sideroakhrestichesky anemia;
- anemias at poisoning with lead;
- specific anemias (megaloblastny, hemolitic, isolated by a lack of B12 vitamin);
- individual hypersensitivity;
- stenosis of an esophageal opening;
- age restriction – 18 years.
Most often negative reactions are registered from a digestive tract:
- disturbances of a chair;
- discomfortable feelings in epigastriums;
- discoloration calla;
Darkening of enamel of teeth because of aggressive influence of iron, allergic answers (temperature increase, an itch, a bronchospasm) is less often noted. In isolated cases anaphylactic reactions, heat inflow, weakness, fast fatigue are registered. Long therapy leads to development of a hemosiderosis.
The instruction on Gino-Tardiferon (A way and a dosage)
The medicine is accepted by per os. Preferable time – before meal. It is recommended to wash down with the sufficient volume of liquid, water.
For prevention appoint on 1 tablet, frequency rate – each 24 hours. For treatment appoint on 1 tablet twice a day. Duration of antianemic therapy is defined in an individual order, estimating weight of anemia, efficiency of therapy, associated diseases, portability of treatment. After normalization of hemoglobin it is not recommended to stop therapy. The average duration of treatment of anemia – about 3 months after stabilization of indicators of laboratory analyses.
Reception of sredneterapevtichesky doses cannot lead to overdose. Main symptomatology: emetic reflex, nausea; the lethal outcome against a collapse is possible. A lethal dose – 180-300 mg on 1 kg. During the first hours poisonings cold sweat, confusion of consciousness, increase of a chair, vomiting with blood, drowsiness, a tsianotichnost of integuments, a melena, shock, heartbeat, falling of a blood pressure is noted up to a coma. In certain cases signs of hyperventilation of lungs, a convulsive syndrome, a nekrotizirovaniye of mucous membranes of the alimentary system are registered.
Imaginary improvement can come in 4-6 hours, but in 12 hours the heavy clinical picture of shock with manifestations of a coagulopathy and a liver failure develops. First aid can consists in the use of milk, crude eggs which will slow down absorption of iron by linkng with it. Effectively timely gastric lavage Na carbonate, physical solution and laxative co-administration.
At explicit overdose appoint Deferoxaminum: per os of 5-10 grams (to dissolve in water of 10-20 ampoules). It is possible to enter parenterally: 1-2 grams intramusculary each 3-12 hours. Use of infusions – intravenously kapelno 1 gram of a medicine is admissible. It is recommended to carry out posindromny therapy. The hemodialysis and a peritoneal dialysis are recognized as effective.
Iron is capable to slow down digestion of zinc and Thyroxine. At simultaneous therapy disturbance of absorption of Penicillaminum, Karbidopy, Levodopa, Ciprofloxacin is noted. Colestyraminum, antacids, magnesium and calcium reduce iron absorption speed. The converse effect is observed at reception of vitamin C, citric acid. The irritating influence of a medicine amplifies at reception of NPVS. Absorption of iron is slowed down against chloramphenicol. It is recommended to maintain an hour window between administrations of drugs. Antimicrobic means (Penicillin, Tetracycline) are capable to create rather resistant complexes with Fe sulfate that considerably worsens iron absorption.
Stimulation of an erythrogenesis amplifies at treatment by glucocorticosteroids. Pharmacological activity of drug decreases at vitamin E reception. The majority of antimicrobic means, antacids, analgetics, streptocides, anticonvulsant medicines worsen digestion of folic acid.
Terms of sale
Gino-Tardiferon it is possible to get without recipe.
To limit the admission of children. Temperature — to 25 degrees Celsius.
Period of validity
Against antianemic treatment the pseudorheumatism can become aggravated. Regular hematologic control of all indicators of blood is recommended. At treatment of patients with a diabetes mellitus it is important to consider that drug contains sucrose. The medicine does not exert impact on a possibility of control of difficult mechanisms.
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