Гинофорт Drug photo

The description is actual on 11.05.2016

  • Latin name: Gynofort
  • ATH code: G01AF15
  • Active ingredient: Butokonazol (Butoconazole)
  • Producer: KB Pharmaceutical Co. (USA), Gedeon Richter (Hungary)


1 gram of cream includes 20 mg of a butokonazol of nitrate.

In addition: 399.78 mg of sorbitol, 80.32 mg of mineral oil, 27.13 mg of monostearate of glyceryl, 27.13 mg of polyglyceryl-3-oleate, 4.52 mg of wax, 50 mg of propylene glycol, 10.13 mg of colloid silicon of dioxide, 1.8 mg of methylparahydroxybenzoate, 0.5 mg of dinatrium of an edetat, 0.5 mg of a propilparagidroksibenzoat, 378.19 mg of water.

Release form

The remedy Gynofortum is made in the form of vaginal cream on 5 grams in the applicator from polypropylene placed in the polisterolovy case packed into the laminated package which is in a cardboard pack.

Pharmacological action

Local antifungal (anti-mycotic).

Pharmacodynamics and pharmacokinetics

Gynofortum cream is the anti-mycotic medicine used in gynecologists for topical treatment of fungal vulval infections.

Derivative an imidazole butokonazol it is characterized by the fungicidal action directed to mushroom strains of the sort Candida (milkwoman), Trichophyton (trichophytosis), Microsporum (cutting deprive), Epidermophyton (epidermophitia). Efficiency of drug is shown thanks to its ability to block transformation of a lanosterol to ergosterol in a cellular mushroom membrane and to increase permeability of the membrane, thereby leading a mushroom cell to a lysis (disintegration).

Bioadhesiveness of vaginal cream is at the high level. At single intravaginalny (in a vagina) a drug route of administration, its active ingredient – butokonazol is present on mucous vaginas for 4-5 days.

System absorption butokonazol at its intravaginalny introduction is equal to 1,7% of the used dose. Indicators of plasma Cmax make 2-18,6 ng/ml and are reached after 13 hours after administration of drug in a vagina.

In an organism butokonazol is exposed to intensive metabolic transformations and, finally, it is partially excreted by kidneys and intestines.

Indications to use

Cream Gynofortum is shown to use for local therapy of the vaginal candidiasis (milkwoman) caused by a mushroom strain of Candida albicans.


Gynofortum is contraindicated to patients with personal hypersensitivity to a butokonazol or other ingredients of cream, girls and girls till 18 years (insufficiency of data on efficiency/safety), and also to pregnant women and the feeding women.

Side effects

Occasionally after intravaginalny administration of cream noted emergence of the passing negative local phenomena which are shown: burning, morbidity, an itch, hypostasis of walls of a vagina, spasms and/or pains in the lower part of a stomach.

Cream Gynofortum, application instruction (Way and dosage)

Unlike other local medicines intended for treatment of vaginal candidiasis (including candles, tablets, pessaries and so forth) and applied repeatedly, therapy by Gynofortum demands its single intravaginalny use. Contents (about 5 grams of cream) of one applicator should be entered deeply into a vagina, into independence of time of day. In case of inefficiency of single use of drug and a persistirovaniya of symptomatology of a disease, the patient needs to pass repeated mycologic research for confirmation or a denial of earlier made diagnosis.

The application instruction of Gynofortum in the applicator

The applicator of this remedy is intended for disposable. Heating of the applicator before its use and use of the applicator with remote earlier protective cap is not allowed.

For the correct administration of drug it is necessary to carry out a number of following manipulations, namely:

  • to take the applicator from a case by removal from it a packaging foil;
  • without removing a special protective cap from the applicator, to extend its piston to a limit, having pulled a hand for a special ring;
  • to remove a protective cap from the applicator and to carefully enter it into a vagina as it is possible more deeply;
  • accurately pressing on the piston completely to force out cream from the applicator;
  • to remove the used applicator from a vagina, to close a cap and to throw out.


For this time about overdose episodes at local use of cream Gynofortum it was not reported. In case of accidental oral administration (proglatyvaniye) of contents of the applicator it is necessary to carry out cleaning of a gastrointestinal tract (a gastric lavage and intestines) and to appoint symptomatic therapy.


Due to the inclusion in composition of cream of the mineral oil capable to damage rubber and latex products, including intra vulval diaphragms and condoms, it is necessary to avoid use of these contraceptive means for at least 72 hours after introduction of Gynofortum.

Terms of sale

Gynofortum is released by the druggist at presentation of the recipe.

Storage conditions

Cream from the milkwoman Ginofort has to be stored in an original packing at indicators of surrounding temperature of 15-25 °C.

Period of validity

From the date of production – 3 years.

Special instructions

In case of preservation of clinical signs of infectious mycotic defeat after carrying out treatment, the patient needs to pass repeated inspection for the purpose of identification of a pathological infestant and confirmation or a denial of earlier made diagnosis.

The accidental proglatyvaniye of cream demands taking measures to cleaning of bodies of a gastrointestinal tract (a gastric lavage and intestines) and carrying out a symptomatic treatment.

At emergence of painful feelings in a vagina or irritation its mucous against use of Gynofortum, it is necessary to stop further use of this remedy.

For the reason inclusion in composition of drug of the parabens capable to cause allergic reactions, its use demands care.


Analogs of Gynofortum are provided other local (candles, gel, vaginal tablets, capsules, pessaries) by the medicines used in gynecology:


  • Gynofortum cream 20mgg 5 of No. 1 applicator

Drugstore of IFC

  • Gynofortum cream of levers. 2% of 5 0 g with the applicator, Gedeon Richtervengriya
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  • Ginofortgedeon Richter (Hungary)


  • Gynofortum of 2% 5 g cream of levers.
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Section: Gynecologic Antimicrobic
in more detail

Education: Graduated from the Vinnytsia national medical university of N. I. Pirogov, pharmaceutical faculty, the higher pharmaceutical education – the specialty "Pharmacist".

Experience: Work in Koneks and Bios-Media pharmacy chains as "Druggist". Work as "Pharmacist" in Avicenna pharmacy chain of the city of Vinnytsia.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Gynofortum surely consult with the attending physician.