Гистак Drug photo

The description is actual on 22.07.2016

  • Latin name: Histac
  • ATH code: A02BA02
  • Active ingredient: Ranitidine (Ranitidine)
  • Producer: Ranbaxy Laboratories Limited, Dewas (India)


In 1 tablet of ranitidine of 150 mg. MKTs, sodium of a kroskarmelloz, magnesium stearate, silicon dioxide, talc as excipients.

Release form

Tablets in a cover of 150 mg.

Pharmacological action


Pharmacodynamics and pharmacokinetics


Blocker of H2-histamine receptors of a mucous membrane of a stomach. Is not an anticholinergic. Blocks basal (day and night) and stimulated secretion, at the same time the quantity of a gastric juice and content of acid in it reduces. Gistak's use in number of 1 tablet oppresses secretion for 12 hours. Does not exert impact on a pepsinia, however its total amount decreases at reduction of quantity of a gastric juice. Slightly influences serumal gastrin after food and on an empty stomach. Does not lower serumal calcium.


At reception it is quickly soaked up from a gastrointestinal tract. Bioavailability about 50%. The maximum concentration are defined in blood in 2-3 hours. Meal does not exert impact on absorption. Only for 15% contacts blood proteins. The main metabolite — N-oxide. All metabolites pharmacological are inactive. Are removed by kidneys and it is insignificant with a stake. About 30% are brought in an invariable look days. T1/2 — 2,5-3 hours. At elderly persons the elimination half-life is extended till 4 o'clock.

Indications to use

  • peptic ulcer;
  • hyper secretory states (system mastocytosis, Zollingera-Ellison's syndrome);
  • erosion and stomach ulcers against reception of NPVS;
  • erosive esophagitis;
  • GERB;
  • prevention of gastric bleeding;
  • prevention of acid aspiration before anesthesia.


  • acute porphyria;
  • hypersensitivity;
  • pregnancy, lactation;
  • age till 18 flyings.

Side effects

Often found undesirable reactions:

  • nausea;
  • discomfort;
  • vomiting;
  • lock or diarrhea;
  • abdominal pains.

Seldom meeting:

Very seldom found undesirable reactions:

Gistak, application instruction (Way and dosage)

Pill is taken inside, entirely, washing down with a moderate amount of water.

Peptic ulcer. At an aggravation Gistak 150 mg accept 2 times (in the morning and in the evening) or 2 tablets for the night. Most often treatment is carried out within a month. For prevention of aggravations take 1 pill before going to bed.

GERB — 150 mg 2 times a day.

The erosion and ulcers connected with reception of nonsteroid drugs — 150 mg 2 times a day within 2 months. It is noted that reception in a dose of 300 mg 2 times 1 month is more effective and increase of a dose does not attract increase in side effects.

Zollingera-Ellison's syndrome. Begin reception with 150 mg 2 times a day. If necessary increases to 6 g a day.

Erosive esophagitis — on 1 tablet 2 times a day. At a severe form of an esophagitis on 1 tablet 4 times a day.

Chronic dyspepsia — 150 mg 2 times a day 1,5 months.

Prevention of a syndrome of Mendelssohn — 1 tablet in 2 hours prior to the carried-out anesthesia and 1 tablet on the eve of operation in the evening.

At a renal failure a daily dose — 1 tablet a day.


It is shown by hypotonia, gait change, bradycardiaventricular arrhythmias and spasms. Treatment consists in a gastric lavage, at emergence of spasms — in/in diazepam, at ventricular arrhythmiaslidocaine. Use of a hemodialysis is effective.


In therapeutic doses the metabolism of diazepam, lidocaine, theophylline, dipheninum, propranolol, Buforminum, metronidazole oppresses. Competes for renal secretion with digoxin, morphine, quinidine, procaineamide, quinine, Vancomycinum, Triamterenum, Trimethoprimum, changing that their clearance.

Changing gastric rn, Gistak changes absorption of drugs. Increase in absorption is noted at joint reception it with triazolamy, glipizidy, midazolam, and decrease at a combination with ketokonazoly, atazanaviry, gefitiniby, delaviridiny. High doses of Gistak reduce excretion kidneys of procaineamide and a metoprolol that leads to increase of level of their concentration in blood. At joint reception with warfarin the prothrombin time changes. Absorption of an atazanavir and delavirdin decreases against Gistak's reception.

Ranitidine strengthens effect of glucose-lowering drug glipizid. At a concomitant use of antacids ranitidine absorption change is possible. Reception with theophylline causes side reactions – tachycardia, spasms, uneasiness.

Interaction of ranitidine with amoxicillin and metronidazole is noted. The concomitant use of alcohol causes increase of its level in blood. Smoking suppresses efficiency of ranitidine.

Terms of sale

Without recipe.

Storage conditions

Temperature is up to 25 °C.

Period of validity

3 years.

Gistak's analogs

Coincidence on the ATH code of the 4th level:

Atsilok, Zantak, Ranisan, Zoran, Rantak, Ulkodin, Ulran.

About Gistake

Ranitidine belongs to blockers of H2 of the second generation which is much better transferred, than Cimetidinum. Ranitidine drugs are used many years at gastroenterological diseases, it is included into the scheme of an irradikation H. pylori together with amoxicillin + metronidazole. Often this drug is used for a symptomatic treatment of heartburn. It is necessary to remember that at sharp cancellation there is a probability of development of "a ricochet syndrome" which is followed by hypersecretion of hydrochloric acid.

"… Pains quickly pass, heartburn and unpleasant feelings in a mouth disappears. Very effective remedy".
"… The effect is. Well helped at an exacerbation of gastritis".
"… I was well helped by these tablets — drank month, there was erosive gastritis".

Many patients prefer instant sparkling tablets Gistak and consider that they act quicker.

Really, peak concentration in plasma is reached twice quicker, than at reception of usual tablets.


  • Gistak of 150 mg No. 20 of a tabletkiranbaksa Laboratoriz Limited
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  • Gistak of 150 mg No. 100 tabl.p.p.o.ranbaxy (India)
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Section: Gastrointestinal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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