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img src="//medicalmed.us/img/Gistohrom.jpg" tppabs="medicalmed.us/wp-content/uploads/2016/06/gistohrom.jpg" alt="Гистохром" title="Гистохром" property="image"> Drug photo
In 1 ml of solution (for intravenous administration) — an ekhinokhroma of 1 mg. Sodium carbonic, water as auxiliary components.
In 1 ml of solution (for use in ophthalmology) — an ekhinokhroma of 0,2 mg. Sodium carbonate, sodium chloride as auxiliary components.
Solution of 1% in ampoules of 5 ml and 10 ml.
Solution of 0,02% in ampoules of 1 ml.
Pharmacodynamics and pharmacokinetics
Water-soluble drug of an ekhinokhrom — the pigment of sea invertebrates possessing high antioxidant activity. Has cardioprotective effect. Unlike other antioxidants reduces accumulation of peroxides in ischemic sites of a myocardium. Lowers creatine kinase level that is important at a myocardial infarction, calcium - the transporting system eliminates disturbances.
Possesses antiagregantny properties therefore it is successfully applied in parallel with thrombolytic therapy. Limits a necrosis zone in the early period to IT. Its use reduces the frequency of arrhythmias at IT, improves sokratitelny ability of a left ventricle that prevents development of heart failure in the first days after a heart attack. Lowers blood cholesterol level.
Its antioxidant and retinoprotektorny action is used in ophthalmology. It improves metabolic processes in a choroid and a retina of an eye, promotes improvement of function of an optic nerve. Reduces hypostasis and accelerates cornea epithelization at a keratitis. It is applied to treatment of a hemorrhagic syndrome in ophthalmology and disturbances of exchange processes of a retina.
After intravenous administration concentration in plasma decreases twice in 12 hours, and the long time remains at one level. The fast elimination comes from blood and well krovosnabzhayemy bodies, and slow — from skin, the hypodermic cellulose, fatty tissue and muscles having not such intensive blood supply. The slowed-down removal is explained, most likely, by deposition in fatty tissue. It is completely metabolized and excreted by kidneys.
Indications to use
- corrosive burns of a cornea;
- diabetic retinopathy;
- dystrophic damages of a retina.
- individual intolerance;
- pregnancies and feeding by a breast (safety is not established);
- age till 18 flyings.
- hyperemia and coloring of a conjunctiva in the place of an injection;
- morbidity in an eye;
- local allergic reactions;
- morbidity on the vein course (at intravenous administration).
Gistokhr, application instruction (Way and dosage)
50-100 mg of 1% of solution (1-2 ampoules on 5 ml) which is dissolved in 20 ml of isotonic solution are entered intravenously. At intravenous drop administration of 50-100 mg dissolve in 100 ml of isotonic solution.
0,02% solution are applied in the form of subkonjyuktivalny or parabulbar injections. On one injection take 0,3-0,5 ml, carry out them daily, it is possible every other day that depends on the course of diseases. Carry out up to 10 injections. To destination 2-3 times a year conduct repeated courses. Drops for eyes Gistokhr are not issued, however ophthalmologists recommend to use for instillations ampullary 0,02% solution — on 2 drops to 5 times a day.
Data are absent.
It is not established. It is impossible to mix with drugs of calcium, iron and containing proteins.
Terms of sale
It is released according to the recipe of the doctor.
Temperature of storage is from 80 to 25 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
Unfortunately, recently due to the lack of drug in pharmacy chain seldom meets comments on him. It is often possible to meet a question which periodically appears since 2011: where it is possible to find who knows in what city there is this drug, explain a situation with release?
Single responses which could be found, testify to its efficiency. Gistokhr for eyes it was appointed in the form of injections under a conjunctiva or parabulbarno depending on a disease. At a keratitis and dystrophy of a cornea patients were hit subconjunctival injections and drops in an eye. At the same time the pain syndrome and hypostasis decreased, quickly there passed epithelization and finally visual acuity increased. At a retinal apoplexy and the vitreous was noted a fast rassasyvaniye of hemorrhages and improvement of sight.
- "… Very effective drug. To me helped to keep an eye which was wanted to be removed";
- "… Very much helps me, hemorrhages resolve very quickly. But this medicine is not in drugstores";
- "… Me periodically punctured this drug at a diabetic retinopathy. Now it is absent!!!";
- "… The newborn has a retinopathy, this drug helps, but it is absent";
- "… Bought to the grandmother right after a heart attack. After droppers there was a red urine, other side reactions were not".
Efficiency of drug is combined with lack of allergic reactions and system manifestations. Brown coloring of a conjunctiva and easy morbidity in an eye after an injection were only in certain cases observed.
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Section: For eyes
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