Гвайфенезин Constitutional formula

The description is actual on 22.02.2016

  • Latin name: Guaiphenesinum
  • ATH code: R05CA03
  • Chemical formula: C10H14O4
  • CAS code: 93-14-1

Chemical name

(RS)-3 (2-metoksifenoks) propane-1,2-diol

Chemical properties

Gvayfenezin, what is it? This chemical compound – an eurysynusic expectorant, is issued as a part of tablets and cough syrups. The molecular mass of Gvayfenezin in Wikipedia is specified = 198,2 grams mol.

Gvayfenezin, what is it? Medicine is often used in a combination with other substances: pseudoephedrine, paracetamol, Phenylephrinum, salbutamol, ratsementoly, etc. In such combination means acts as the sedative, liquidating feeling of uneasiness drug.

Pharmacological action

Mucolytic, expectorant.

Pharmacodynamics and pharmacokinetics

Gvayfenezin has the expressed mucolytic effect, stimulates work of secretory cells of a mucous membrane of bronchial tubes. Substance considerably reduces viscosity of a phlegm, stimulating to produce neutral polysaccharides and depolymerizing acid. Also phlegm volume increases that considerably facilitates its evacuation from bronchial tubes. Under effect of the medicine unproductive dry cough quickly passes into productive.

Means is quickly and well soaked up from a gastrointestinal tract. Half an hour later after inclusion in blood rather high concentration of substance is observed. The elimination half-life makes about an hour. Drugs act on Gvayfenezin's basis within 3,5-4 hours. Medicine in liver tissues is metabolized, and brought out of an organism with a phlegm (lungs) and in the form of inactive metabolites through kidneys.

Indications to use

Drug is used:


Medicine is contraindicated:

  • at wet cough if there is a lot of phlegm and it well departs;
  • to patients with stomach ulcer and a 12-persny gut;
  • if earlier at the patient gastric bleeding was observed;
  • to children till 2 flyings;
  • at an allergy to active ingredient.

Extra care is recommended to be observed:

  • to pregnant women;
  • to children aged till 12 flyings;
  • during a lactation.

Side effects

Usually medicine is well transferred by patients.

Side reactions of Gvayfenezin:

Gvayfenezin, application instruction (Way and dosage)

Drug is appointed for intake. The scheme of treatment and the mode of dosing reaches individually, depending on an illness and a dosage form.

According to the instruction on Gvayfenezin in the form of syrup, to persons aged from 12 flyings appoint 200-400 mg of substance, 3-4 times a day. Medicine is drunk after food.

For children from 6 to 12 years it is necessary to correct a dosage to 300-800 mg a day, frequency rate of reception the same. Aged from 2 till 6 flyings it is possible to appoint no more than 50-100 mg of medicine, each 6-8 hours.

Duration of treatment depends on portability and dynamics of a disease.


There are no data on overdose by drug. If the patient accepted a large number of medicine, it is necessary to see a doctor.


At a concomitant use with codeine process of removal of a phlegm considerably is at a loss.

This substance is well combined with antimicrobic medicines, cardiac glycosides, bronchial spasmolytics.

Gvayfenezin's combination to the drugs oppressing work of the central nervous system, including ethanol strengthens its sedative action.

Terms of sale

According to the recipe.

Storage conditions

Means storage conditions various, depending on a dosage form.

Special instructions

During treatment by drug urine can be painted in pink color.

When passing therapy plentiful drink, vibration massage and a postural drainage for stimulation of an otkhozhdeniye of a phlegm is recommended.

This substance can show false positive result at capture of urine on 5-hydroxyindolacetum or vanililmindalny acid. Therefore it needs to stop be drunk in 2 days prior to collecting urine.

If in 7 days after an initiation of treatment at the patient there do not come improvements in a state, high temperature keeps, there does not pass the headache, rash and a pharyngalgia, then it is recommended to see a doctor behind consultation.

It is undesirable to begin to drink medicine without consultation with the specialist.

To children

For children aged from 2 flyings drug is safe to reception. However it is necessary to correct a daily dosage, depending on age of the patient.


At patients 60 years are more senior more often side reactions on drug are observed.

Gvayfenezin is a part of drugs Tussin, Tussin Plus (dekstrometrofan) and bronchial tube Coldrex.

In a combination with pseudoephedrine substance is a part of medicine Sudafed.

Soluble powder of Viks Aktiv Simptomaks Plus contains this substance, paracetamol and Phenylephrinum.

In combination with Bromhexine, ratsementoly and salbutamol means is in composition of drugs Kashnol, Askoril an ekspektorant, Kofasma. Also Gvayfenezin contains in tablets and drops StoptussinDzhoset, Askoril.


About drug use good. At reception of therapeutic dosages according to testimonies of the doctor side reactions, as a rule, are not shown.

Section: Active ingredients
PAY ATTENTION! Information on active ingredients on the website is help generalizing, collected from public sources and can form the basis for making decision on use of these substances it is not aware of treatment. Before substance use Gvayfenezin surely consult with the attending physician.