Hayrabezol

Хайрабезол Drug photo

The description is actual on 29.07.2016

  • Latin name: Hirabezol
  • ATH code: A02BC04
  • Active ingredient: Rabeprazol (Rabeprazole)
  • Producer: HiGlance Laboratories Pvt. Ltd. (India)

Structure

In 1 tablet of a rabeprazol of 20 mg or 10 mg. Magnesium oxide, Mannitolum, corn starch, povidone, a hypro rod, the sodium stearylfumarating as excipients.

Release form

Kishechnorastvorimy tablets.

Pharmacological action

Antiulcerous, lowering secretion of a gastric juice.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Antiulcerous drug, representative of inhibitors of the protonew pump. Blocks secretion of Acidum hydrochloricum (a final stage), reducing stimulated and basal secretion. Well gets into stomach cells, rendering cytoprotective effect.

Anti-secretory action comes within an hour, and the general time of action — 48 hours. Recovery of secretory activity is noted in 3 days after the end of treatment. Drug does not exert impact on cardiovascular system and TsNS.

Pharmacokinetics

Extent of absorption high is soaked up in a small intestine. Cmax in blood is defined in 3,5 hours. Bioavailability about 52%, and it does not increase at numerous reception. For 97% contacts blood proteins. It is metabolized in a liver with the assistance of system of cytochrome. It is removed by kidneys. T1/2 makes 1,5 hours.

Indications to use

  • GERB;
  • peptic ulcer in an aggravation stage;
  • hyper secretory states;
  • Helicobacter pylori eradikation;
  • stressful ulcers;
  • prevention of aggravations of the peptic ulcer initiated by Helicobacter pylori.

Contraindications

  • pregnancy;
  • feeding by a breast;
  • hypersensitivity;
  • age till 12 flyings;

With care it is applied at a heavy liver and renal failure.

Side effects

The met side reactions are more often:

The met side reactions are more rare:

Hayrabezol, application instruction (Way and dosage)

Pill Hayrabezol is taken inside, in the morning to food, swallowed without chewing.

Peptic ulcer at an aggravation — 20 mg of 1 times in the morning till 6 weeks. A dose for children of 12 years — 20 mg of 1 times a day.

GERB — once a day till 8 weeks. The supporting treatment is carried out in a dose of 10 mg of 1 times a day. At GERB without esophagitis accept 10 mg a day, month.

Hayrabezol of 20 mg is included into schemes of an eradikation Helicobacter pylori in combination with klaritromitsiny and amoxicillin.

At a renal failure and a liver the dose does not decrease. Drug withdrawal does not attract a ricochet syndrome. Secretion is recovered in 2-3 days.

Overdose

Cases of overdose are not known. The specific antidote is absent. Rabeprazol is badly brought at a dialysis. Symptomatic therapy is carried out.

Interaction

Slows down removal of the drugs which are metabolized a microsomal oxidation in a liver (indirect anticoagulants, diazepam, Phenytoinum). Reduces concentration of a ketokonazol and digoxin. Let's combine with warfarin and theophylline. Interaction with liquid antacids is not noted.

Terms of sale

According to the recipe.

Storage conditions

Temperature is up to 25 °C.

Period of validity

3 years.

Hayrabezol's analogs

Pariyet, Zulbeks, Zolispan, Rabelok, Razo, Noflyuks.

About Hayrabezole

According to researches at which drug was appointed at treatment of erosive and ulcer defects of a stomach for the 2nd day of therapy at 75% of patients the pain syndrome decreased, and after week reception of complaints nobody showed. At 91% of patients by the end of the 2nd week of treatment by results of FGDS healing of erosive and ulcer defects is noted. Drug is noted by lasting anti-secretory effect, at its reception the number of refluxes decreases. All this is confirmed by responses of patients.

  • "… Medicine Hayrabezol was appointed at an exacerbation of an ulcer. The health improved every other day. It was treated month — there passed unpleasant feelings and stomach aches".
  • "… I suited tablets, I am happy with result of treatment. Cost not much".
  • "… Drug was pleasant to me!!! Pains and heartburn disappeared. Earlier Pariyet's saw, but it is very expensive. Did not see a difference in efficiency of those and other tablets".
  • "… I accept at exacerbations of an ulcer. Personally helps me. Conveniently what needs to be accepted only once in day and packagings lasts for 15 days. The price and efficiency arranges. I did not feel Pobochek".
  • "… I am helped only by Pariyet. I drink only this drug".

From side effects the insignificant headache and emergence of locks was noted.

Zdravzona

  • Hayrabezol of 10 mg No. 15 of a tablet
  • Hayrabezol of 20 mg No. 15 of a tablet
to show still
Section: Gastrointestinal
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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