Hikontsil

Хиконцил Drug photo

The description is actual on 29.07.2016

  • Latin name: Hiconcil
  • ATH code: J01CA04
  • Active ingredient: Amoxicillin (Amoxicillin)
  • Producer: Sandoz (Austria); KRK (KRKA), Slovenia

Structure

In 1 capsule of amoxicillin of 250 mg, 500 mg. Silicon dioxide, magnesium stearate as excipients.

In 5 ml of suspension of amoxicillin of 125 mg or 250 mg.

Form release

Powder in a bottle for preparation of suspension with the content of active agent of 125 mg / 5 ml and 250 mg / 5 ml.

Capsules of 250 mg and 500 mg.

Pharmacological action

Antibacterial, bactericidal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Active agent — amoxicillin — semi-synthetic penicillin. Inhibits process of synthesis of a cellular membrane of bacteria, suppressing activity of enzymes and transpeptidases. The lack of peptidoglikan of a cell wall results in its defect, osmotic instability and destruction. Is a bactericidal antibiotic.

In comparison with penicillin, is more effective concerning Listeria and enterococci and loses in the relation of Streptococcus pneumoniae, pyogenes, agalactiae a little. Action on Neisseria is equivalent to effect of penicillin. The majority of the stafilokokk producing a penicillinase are steady against effect of drug. Escherichias, salmonellas and shigellas are sensitive to it. In certain doses is beta laktamnym an antibiotic. After reception action begins in 1 hour and lasts till 8 o'clock.

Pharmacokinetics

It is completely soaked up in a gastrointestinal tract. Does not collapse in acid medium of gastric contents. The maximum concentration of active ingredient in blood is defined in 2 hours, and it depends on a dose. The minimum concentration is defined in 8 hours.

Does not kumulirut in an organism. To 25% of active agent contacts proteins. Well gets into fabrics: lungs, a liver, a uterus, mucous bosoms of a nose, a middle ear where therapeutic concentration are defined. It is highest in bile (in 10 times more, than in plasma). Extent of penetration into a brain and liquor is higher at an inflammation. There passes the placental barrier. In milk is defined in small amounts.

It is removed by kidneys — 70% of a dose in not changed look and insignificant quantity with bile. An elimination half-life of 60-90 min., it increases till 7 o'clock at a renal failure.

Indications to use

Contraindications

With care it is applied during pregnancy.

Side effects

The met side reactions are more often:

  • diarrhea, nausea;
  • vomiting;
  • erythematic and papular rash.

The met side reactions are more rare:

Hikontsil, application instruction (Way and dosage)

Capsules Hikontsil accept entirely, after food, washing down with enough liquid. The adult appoint 500 mg 3 times day, in rare instances — on 1000 mg 3 times.

Hikontsil's suspension more often is appointed to children as it is convenient to dose and accept it. For its preparation use boiled water which is poured in a bottle to a tag. After that the bottle is well stirred up.

To children from 5 to 10 years appoint 250 mg three times a day, from 2 to 5 years — 125 mg three times a day, till 2 flyings according to body weight — 20 mg to kg a day, divide a daily dose into 3 receptions. The average course of treatment makes 7-12 days.

Treatment continues after disappearance of symptoms of a disease of 2 more days.

Overdose

Overdose is shown by nausea, diarrhea and vomiting. The gastric lavage, reception of sorbents and salt laxatives is undertaken. The hemodialysis is possible.

Interaction

Joint reception with antacids, purgatives, a glycosamine and aminoglycosides reduces absorption.

On the contrary, ascorbic acid raises it. Aminoglycosides, cephalosporins, rifampicin, Vancomycinum have sinergidny effect. Antagonistic action is noted at reception with macroleads, linkozamida, tetracyclines, chloramphenicol, streptocides.

At reception with indirect anticoagulants their efficiency increases. Efficiency of oral estrogensoderzhashchy contraceptives decreases, the risk of bleedings of "break" appears. Diuretics, NPVS, Allopyrinolum, phenylbutazone increase concentration of amoxicillin. Reception with Allopyrinolum in addition increases risk of emergence of rash. Amoxicillin increases toxicity of a methotrexate and accelerates digoxin absorption.

Terms of sale

According to the recipe.

Storage conditions

Temperature is up to 25 °C.

Period of validity

3 years.

Hikontsil's analogs

Amosin, Amoxicillin, Gramoks-D, Flemoksin, Danemoks, Ekobol, Ospamoks.

About Hikontsile

The antibiotic Hikontsil is generic of amoxicillin and is most often applied in the eradikatsionny schemes H.pylori — the associated peptic ulcer together with klaritromitsiny and ultopy. It should be noted that degree of an eradikation and frequency of scarring of ulcer defects are high, and the cost of a course of treatment is much lower, than when using original drugs. This treatment allows to achieve good results — 100% of epithelization of defects and an eradikation of H.pylori that was confirmed by additional methods of research.

  • "… Superficial gastritis also bulbit. Accepted this drug and Lantorol. In 2 weeks on repeated gastroscopy everything is normal".
  • "… Me appointed at a duodenum ulcer the scheme from three drugs including this. Transferred not really well — there was nausea, after all accepted two antibiotics. In three weeks passed control gastroscopy and everything is good".

The second disease on amoxicillin use frequency — acute antritis. Drugs with this active ingredient are safe and are well transferred. The action spectrum covers almost all species of bacteria which cause acute antritis. The exception is made by the strains producing a penicillinase. If in two-three days an antibioticotherapia does not give relief, drug change for another (the second line, usually azithromycin, klaritromitsin, cephalosporins).

Drugs of penicillin are widely used also in children's practice.

  • "… The son does not want to drink tablets therefore at quinsy the doctor recommended Hinkotsil for suspension preparation. Were treated week that there were no complications. Confuses that an antibiotic, but in this case without it anywhere".
  • "… The child accepted this suspension. Wrote out at otitis. By the end of the second day of allocation from an ear stopped, temperature decreased. It is pleasant to me that it is an antibiotic penicillinic — not such harmful to the child".

Apteka24

  • Hikontsilkrka (Slovenia)
  • Hikontsilkrka (Slovenia)

BIOSPHERE

  • Hikontsil of 500 mg No. 16 kaps.
  • Hikontsil of 250 mg No. 16 kaps.
  • Hikontsil of 250 mg / 5 ml of 100 ml por.d/susp. for reception vnutrsandoz Gmbh (Austria)
  • Hikontsil of 125 mg / 5 ml of 60 ml por.d/susp. for intake
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Section: Antibiotics
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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