Chondroitin sulfate

Drug photo

The description is actual on 07.07.2016

  • Latin name: Chondroitin sulfate
  • ATH code: M01AX25
  • Active ingredient: Chondroitin sulfate (Chondroitin sulfate)
  • Producer: Ellara of Ltd company, Synthesis of joint stock company (Russia), Syntex (Argentina), New Zeland Pharmaceuticals (New Zealand)

Structure

In 1 ampoule chondroitin sodium sulfate — 100 mg.

Release form

Lyophilic powder on 100 mg in ampoules.

Pharmacological action

Hondroprotektivny, hondrostimuliruyushchy.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Chondroitin sulfate is the mucopolysaccharide which is the main component of a cartilaginous matrix (together with collagenic fibers). This substance participates in creation of bone and cartilaginous tissue. Suppresses enzymes which break structure of a cartilage in this connection brakes its degeneration.

The drug received from cartilaginous tissues of cattle, blue, sharks by a fermentation method promotes recovery of a cartilaginous surface of a joint, normalizes production of intra joint liquid. It leads to increase in mobility of joints, reduction of pains and delay of progressing of an osteoarthrosis. Possesses antiinflammatory and analgeziruyushchy action, reduces pains when walking and at rest, reduces need of the patient for NPVS.

Influence of drug on a pain syndrome and functional activity of joints is shown and proved in clinical trials.

Pharmacokinetics

At intramuscular introduction active ingredient is easily soaked up. With max in 1 hour after an injection. Collects in synovial fluid. It is removed by kidneys within a day.

Indications to use

Contraindications

With care it is applied at pregnancy and at children.

Side effects

The instruction on Chondroitin sulfate (A way and a dosage)

The drug is administered intramusculary, every other day on 1 ml. Lyophilisate is dissolved, adding to an ampoule 1 ml of water for injections. At good tolerance from the fourth injection enter 2 ml. On a course of treatment — 30 — 35 injections.

Repeated courses in half a year are desirable.

The application instruction contains the warning that for achievement of clinical effect it is necessary to execute not less than 30 injections, in that case the effect remains several months. For prevention of aggravations conduct repeated courses which duration is established by the doctor.

Overdose

Cases of overdose are not registered.

Interaction

Drug is compatible to glucocorticosteroids and NPVP. At simultaneous use of antiagregant, anticoagulants and fibrinolitik strengthening of their action is possible.

Terms of sale

Prescription issue.

Storage conditions

Temperature of storage is up to 22 °C.

Period of validity

3 years.

Analogs

Injection forms: Mukosat, Artradol, Hondrogard. Drugs for intake: Artron hondreks, Mukosat, Struktum, Hondroitin-Vert, Artra Hondroitin, Chonsuridum, Hondroitin-Akos.

Responses on Chondroitin sulfate

The main glikozaminoglikana which are responsible for health of joints are hyaluronic acid and chondroitin sulfate. The last is a part of cartilaginous tissue and plays a role of greasing of joint surfaces. With age, when its development in an organism is insufficient, there are changes in cartilaginous tissue, painful feelings in joints and their mobility worsens, these substances in the form of drugs are appointed for stimulation of recovery of cartilaginous tissue (synthesize proteoglycans) and delay of deformation of a cartilage.

It should be noted that similar drugs are most effective at initial stages of osteoarthroses when recovery of a cartilage is still possible.

Drugs of hyaluronic acid: Hialubriks, Gialgan, Adant.

Hondroitin sulfate is a part of the known drugs: Artron hondreks, Mukosat, Hondroitin-Akos, Struktum, Hondroitin-Vert, Artra Hondroitin, Chonsuridum. Use it in a dose of 1500 mg a day reduces local morbidity and increases functional capacity of a joint.

About drug positive, with rare exception, when patients from - for emergence of side reactions in the form of the small tortoiseshell, an itch of skin and reaction in an injection site were forced to stop a course of treatment. Those patients who well transferred drug treated 2-3 times a year within several years. In breaks between injections passed to reception of any hondroprotektor inside. Only at such mode of treatment received good results mobility of joints and a backbone improved, pains and a crunch in joints disappeared. Subjective improvements were confirmed and instrumentalno by improvement of radiological indicators.

Hondroprotektora of the 3rd generation are the combined drugs containing chondroitin and a glycosamine (a hydrochloride or sulfate). The combination of two active ingredients mutually supplements and strengthens pharmacological effects. Such combination gives effective reduction of a pain syndrome therefore many patients give preference to the combined drugs which at the moment are priority.

Zdravzona

  • Chondroitin mg sulfate 100 lyophilisate for Preeg. solution for injections No. 10 of an ampulyellar of MTs
to show still
Section: For joints
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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