Ибупрофен Drug photo

The description is actual on 30.07.2015

  • Latin name: Ibuprofen
  • ATH code: M01AE01
  • Active ingredient: Ibuprofen (Ibuprofen)
  • Producer: Joint stock company Borisovsky ZMP, PAO Vitamins, CJSC Farmatsevticheskaya Darnits's (Ukraine) firm, Hemofarm (Serbia), Belmedpreparata's RUP (Republic of Belarus)


In the form of suppositories 60 mg of active agent, solid fat are a part of the Ibuprofen.

Structure of tablets: ibuprofen (200 or 500 mg), potato starch, magnesium stearate, aerosil, vanillin, beeswax, edible gelatin, dye azoruby. hydroxymagnesium carbonate, wheat flour, low-molecular povidone, sucrose, titanium dioxide.

In ointment and gel active agent contains in concentration of 50 mg/g, in suspension — in concentration of 20 mg/ml.

Auxiliary components of gel: an ibuprofen (50 mg/g), ethanol, propylene glycol, Dimexidum, carbomer 940, trietanolamine, oil of not role and lavender, methylparahydroxybenzoate, the water purified.

Auxiliary components of ointment: dimethyl sulfoxide, macrogoal 400 and 1500.

Release form

  • ointment Ibuprofen of 5% (25 g);
  • the tablets Ibuprofen p / about 200 and 400 mg;
  • gel Ibuprofen of 5% (20 and 50 g);
  • candles Ibuprofen of 60 mg;
  • children's Ibuprofen in the form of oral suspension (20 mg/ml 100 ml).

The ATH code for suspension, rectal suppositories, tablets — M01AE01, for means of outside therapy (ointment and gel) — M02AA13.

Pharmacological action

Antiinflammatory, antipyretic, analgeziruyushchy.

Pharmacodynamics and pharmacokinetics

Effects of drug are caused by suppression of biosynthesis of Pg by COX enzyme inhibition.

Suppresses aggregation of thrombocytes. Does not exert impact on proteins which take part in a blood coagulation. Increases time of bleedings a little.

At external use at the patient reduction of a joint pain at rest and in the movement is noted; reduction of morning constraint, swelling and puffiness of joints, increase of flexibility and volume of movements of joints.

At oral administration well (for 80%) it is soaked up in a gastrointestinal tract. The concomitant use with food slows down absorption, but does not exert impact on its volume. Tsmakh is 2-4 h.

The hypothermal effect develops in 1 h after reception. T1/2 — from 2 to 4 h. Communication with plasma proteins — 90-99%.

Gets into cavities of joints slowly, is late in synovial fabric in which collects in bigger, than in plasma, concentration.

On achievement of antiinflammatory effect it is required from several days to 2 weeks of systematic use of drug.

Biological activity is associated with S-enantiomerom.

After absorption pharmacological the inactive R-form (about 60%) is slowly transformed to a S-form. Products of a metabolism are removed mainly by kidneys and — partly — with bile. No more than 1% of an ibuprofen are in pure form removed.

Substance is not defined in breast milk. Full removal is carried out during 24 h.

Indications to use

Ibuprofen — what is it?

The ibuprofen is a non-narcotic analgesic which belongs to NPVP group. Possesses the expressed antiinflammatory activity.

These properties allow to use drug at a heat and pain (weak and average intensity), a rheumatic polimialgiya, inflammatory and degenerative diseases the ODE.

The ibuprofen is included by WHO in the list of means of prime necessity.

From what the Ibuprofen in tablets?

Tablets are appointed at:

  • inflammatory diseases of a backbone and joints (ankylosing spondylarthritis, gouty and pseudorheumatism, osteoarthrosis, etc.);
  • moderate pain of various etiology (medicine helps at pain at monthly, at a dentagra, at a headache, at a migrenozny attack, a mialgiya, neuralgia, posttraumatic and postoperative pains, etc.);
  • to fever against infectious or "catarrhal" diseases.

Ibuprofen: from what these tablets?

It is necessary to remember that tablets (as well as other dosage forms) are intended for symptomatic therapy, reduction of intensity of pain and stopping of an inflammation, medicine of influence does not render on progressing of pathology.

Indications to use of gel and ointment

Gel and ointment with an ibuprofen are effective at inflammatory and degenerative diseases of skeletal and muscular system:

  • psoriasis, gouty and pseudorheumatism;
  • humeroscapular periarthritis;
  • osteoarthrosis;
  • radicular syndrome at osteochondrosis;
  • Bekhterev's diseases;
  • bursitis;
  • sciatica;
  • lumbago;
  • radiculitis;
  • mialgiya;
  • tendovaginitis;
  • tendinitis;
  • to the aggravated gout;
  • injuries at which integrity of soft tissues is not broken (gap/sprain, dislocation, bruise, posttraumatic hypostasis, etc.).

Indications to use of suppositories and syrup

Syrup and candles the Ibuprofen are dosage forms which were developed especially for use in pediatric practice. They are appointed to children for:

  • decrease in temperature at a SARS, children's infections, flu and other infectious and inflammatory diseases which are followed by a hyperthermia;
  • decrease in temperature at post-inoculative reactions;
  • reduction of intensity of poorly/moderately expressed pain (means can apply from a dentagra and from a headache, at ear or throat pain, injury of ligaments, at neuralgia, etc.).

Suppositories are intended for children of 3-24 months, syrup the Ibuprofen is applied to treatment of children for 3 months till 12 flyings.

For what the Ibuprofen in the form of solution is applied to injections?

Pricks are applied to treatment of VPS at premature newborns.


General contraindications:

  • full or partial combination of symptoms of a triad of Fernán-Vidal (including in the anamnesis);
  • existence of erosion and ulcers in the digestive channel;
  • disturbances of a hemostasis;
  • active gastric/intestinal bleeding;
  • heavy insufficiency of function of a liver;
  • the progressing pathologies of kidneys;
  • renal failure at which Clcr does not exceed 30 ml/min.;
  • states after carrying out AKSh (aortocoronary shunting);
  • chronic inflammatory processes in intestines;
  • the confirmed hyperpotassemia;
  • 3rd trimester of pregnancy;
  • hypersensitivity.

In pediatrics suspension and candles are applied since 3 months, a tablet — from 6-tiletny age.

It is necessary to be careful, appointing the Ibuprofen at:

  • cirrhosis which is complicated by portal hypertensia;
  • gastritis;
  • colitis;
  • enteritis;
  • stomach ulcer / 12-tiperstnoy-tiperstnoy;;;;;;;
  • nephrotic syndrome;
  • insufficiency of function of heart, kidneys or liver;
  • arterial hypertension;
  • cerebrovascular diseases;
  • dis-or lipidemia;
  • diseases of peripheral arteries;
  • existence of a helikobakterny infection;
  • heavy somatic pathologies;
  • diseases of blood of not clear etiology.

Also with care drug is appointed to the persons suffering from alcoholism, it is long the using NPVP accepting peroral GKS, SIOZS, antiagregant and anticoagulants, in the first 26-27 weeks of pregnancy, to the feeding women.

Children about one year should give drug only according to the recommendation of the pediatrician.

Side effects

The following side effects are listed in the summary on dosage forms for oral use and rectal candles:

  • NPVP-gastropathy, dryness, irritation and/or ulceration of a mucous oral cavity, mouth pain, pancreatitis, aphthous stomatitis;
  • hepatitis;
  • bronchospasm, asthma;
  • noise/ring in ears, decrease in hearing;
  • doubling or decrease in clearness of visual objects, irritation and xerophthalmus, toxic defeat of an optic nerve, scotoma, the century, a chemosis swelled;
  • nervousness, headache, uneasiness, confusion of consciousness, sleeplessness/drowsiness, dizziness, mental and motor excitement, hallucinations, a depression, aseptic meningitis (seldom and mainly at patients with autoimmune diseases);
  • decrease in sokratitelny ability of a cardiac muscle, increase of the ABP, tachycardia;
    OPN, polyuria, nephrotic syndrome, allergic nephrite, cystitis;
  • hypersensitivity reactions;
  • anemia, trombotsito-and leukopenia, Verlgof's illness, agranulocytosis;
  • sweating strengthening.

The probability of vision disorders, developments of gastric/intestinal bleedings and an ulceration of walls of the digestive channel increases at long reception of high doses of the Ibuprofen.

Drug influences laboratory indicators, namely:

  • increases a bleeding time;
  • reduces serumal concentration of glucose, Clcr, gematokritny number and level of hemoglobin;
  • increases activity of transaminases of a liver;
  • increases concentration of creatinine in blood serum.

Side effects at topical administration in the form of gel/ointment:

  • feeling of pricking/burning;
  • dermahemia.

At prolonged use of means of outside therapy NPVP system effects can develop inherent in all.

Application instruction of the Ibuprofen

Tablets Ibuprofen: application instruction

The optimum dosage for children is more senior than 12 years and adults — 3-4 tablets of 200 mg. For achievement of the necessary effect it is possible to increase a dose to 1,2 g/days (it is necessary to divide it into 3 receptions).

When the necessary medical effect is reached, a daily dose it is necessary to lower to 3-4 tablets 200 mg a day.

The first dose is accepted to food in the morning, washing down with enough liquid (it will allow drug to be soaked up more quickly in a gastrointestinal tract). Further for day a pill is taken after food.

The highest single dose — 400 mg (2 tablets of 200 mg), daily — 1,2 g (no more than 6 tablets of 200 mg during 24 h). The repeated dose is not recommended to be accepted earlier, than in 4 h. Without medical consultation drug is accepted by no more than 5 days in a row. Also consultation of the specialist is necessary in cases when tablets are used for treatment of the child more young than 12 years.

The child of 6-12 years can give up to 4 times a day on 1 tablet. The indispensable condition — weight is more than 20 kg. Between receptions of tablets it is necessary to maintain an interval not less than 6 h the Highest dose for the specified group of patients — 30 mg/kg/days.

Differences are in how to accept drugs of different producers (for example, Ibuprofen-Belmed, Ibuprofen-Hemofarm or Ibuprofen-Darnitsa) is not present.

The instruction on candles

Suppositories apply rektalno.

At pain and fever drug should be dosed, being guided by age and the child's weight. The single dose varies ranging from 5 to 10 mg/kg. Frequency rate of uses — 3-4 rubles/days the Highest dose — 30 mg/kg/days.

In the application instruction for children it is specified that patients with the body weight from 5,5 to 8 kg (3-9 months) need to enter 60 mg (on 1 suppository) every 6-8 hours, but no more than 3 suppositories a day. The highest dose for patients with the body weight from 8 to 12,5 kg (9-24 months) — 240 mg/days (4 suppositories on 60 mg).

For stopping of fever which is a consequence of immunization children till 12 months should enter 1 suppository of 60 mg and if in it there is a need, 1 more in 6 h.

As candle antipyretic the Ibuprofen it is possible to apply no more than 3 days to children in a row, and quality of an analgetic — no more than 5 days in a row.

If fever remains after this time, consultation of the doctor is necessary.

Gel Ibuprofen: application instruction

To adults and children 12 years are more senior it is necessary to squeeze out a strip of gel 4-10 cm long and the easy movements to rub drug before full absorption to the area of a projection of pain.

It is possible to repeat procedure not earlier than later 4 h During the day the Ibuprofen is applied by no more than 4 times. The dose depends on extensiveness painfully of a zone and varies ranging from 50 to 125 mg.

For children of 6-12 years the single dose is equal to gel from 2 to 4 cm long strip volume. It is possible to use drug no more than 3 rubles/days.

Treatment is continued by from 2 to 3 weeks.

Ointment Ibuprofen: application instruction

Ointment is applied outwardly according to the same scheme, as gel. Medicine is applied on a healthy place of 3 or 4 rubles/days within 2-3 weeks. The single dose is equal to gel from 5 to 10 cm long strip volume.

How to accept the Children's Ibuprofen (suspension)?

3 rubles/days in a dose of 5-10 mg/kg give to children suspension.

Children about one year drug can give only to destination the pediatrician. The highest dose for babies — 10 ml/days (on 2,5 ml of 4 rubles/days).

For children from a year to 12 flyings 3 rubles/days in a dose from 5 to 15 ml give syrup.

If pain and fever at the child of 3-6 months are a consequence of vaccination, on 5-7,6 kg of body weight it is necessary to give 2 rubles/days on 2,5 ml of suspension. After the first dose administration of drug is repeated not earlier than in 6 h.

The instruction on solution the Ibuprofen for children

Pricks of the Ibuprofen are appointed to exclusively premature babies with heart pathologies (in particular, with open Botallovy Canal).

Treatment is carried out in an intensive care unit and under supervision of a neonatolog. The ibuprofen in/in is entered by 3 bucketed times at 24 o'clock. The dosage is selected depending on the child's weight.

The first dose — the 10, second and third — 5 mg/kg.

Pour in drug slowly (within 15 minutes), it is preferable in an undiluted look. If necessary the entered volume is adjusted NaCl solution of 0,9% (or glucose of 5%). The remained unused solution is utilized.

When scoping of the entered solution consider the total daily amount of the appointed liquid.

If after the child receives the 1 or 2 dose, he develops an explicit oliguria or an anury, the following dose is entered only after recovery of normal diuresis.

If botall the channel is open also in 24 hours after introduction of the last dose or opens repeatedly, appointment of a repeated course which also consists of 3 doses of drug is allowed. If in this case it is not possible to achieve closing of a channel, surgical treatment can be required by the child.


Overdose is followed:

  • abdominal pains;
  • block;
  • nausea/vomiting;
  • sonitus;
  • drowsiness;
  • headache;
  • depression;
  • metabolic acidosis;
  • coma;
  • OPN;
  • bradycardia;
  • hypotension;
  • fibrillation of auricles;
  • apnoea.

Treatment: carrying out a gastric lavage (it is reasonable during 1 h after administration of drug), purpose of enterosorbents, an artificial diuresis, plentiful alkaline drink, symptomatic therapy which purpose is correction of gastric and intestinal bleedings, the ABP, KShchR, etc.


The drugs inducing a microsomal oxidation increase development of hydroxylated active products of a metabolism and, thus, increase risk of development of serious hepatotoxic reactions. The drugs inhibiting a microsomal oxidation, opposite reduce it.

The ibuprofen reduces sodium - and diuretic activity of a hydrochlorothiazide and furosemide, efficiency of hypotensive and uricosuric drugs (including APF and BMKK inhibitors), antiagregantny and antiinflammatory action of ASK.

Potentsiiruyet action of antiagregant, indirect anticoagulants, fibrinolitik, insulin and oral forms of hypoglycemic drugs, ulcerogenic action with bleedings of GKS and ISS.

Absorption of drug decreases in a combination with Colestyraminum and antacids. Strengthening of analgeziruyushchy effect is promoted by caffeine. In a combination with trombolitika and anticoagulants promotes increase of risk of development of bleedings.

Tsefotetan, Tsefoperazon, Tsefamandol, Plikamitsin and valproic acid increase the frequency of emergence of deficit of a prothrombin (a coagulant factor) in blood.

Miyelotoksichny drugs promote strengthening of a gematotoksichnost of the Ibuprofen. The drugs Au and Cyclosporine strengthen influence of drug on synthesis of Pg in kidneys therefore its nephrotoxicity increases. In turn, the Ibuprofen increases concentration of cyclosporine in a blood plasma and its hepatotoxic.

The drugs blocking canalicular secretion increase concentration of an ibuprofen in a blood plasma and reduce its removal.

Terms of sale

Without recipe.

The recipe on Latin on tablets:

Rp.: Tab. No. 30 Ibuprofeni 0,2.
D.S. on 1 tab. 3 r/.

Storage conditions

To store at a temperature up to 25 degrees Celsius.

Period of validity

Tablets and suspension are suitable for use during 3 flyings after a date of issue, gel, ointment and suppositories — during 2 flyings.

Special instructions

At heavy pathologies of a musculoskeletal system it is reasonable to combine means of outside therapy with reception of the NPVP oral forms.

During use of the Ibuprofen it is necessary to control changes of function of kidneys/liver and a picture of peripheral blood.

At emergence of signs of the NPVP-gastropathy the patient needs carrying out blood test with definition of gematokritny number and Hb, the analysis a calla on the occult blood, to an ezofagogastroduodenoskopiya. For the prevention of development of a gastropathy it is necessary to combine reception of the Ibuprofen with administration of drugs of PgE.

In need of definition 17-KC, drug is cancelled in 48 hours prior to research.

The patients accepting the Ibuprofen should abstain from any activity which demands high concentration of attention and speed of mental/motor reactions.

It is necessary to remember that this means for decrease in probability of development of undesirable reactions from the alimentary system has to be used in a minimal effective dose and the shortest course.

Analogs of the Ibuprofen

Synonyms (analogs of the Ibuprofen with the same active ingredient): Ibuprofen-Hemofarm, Nurofen, INSTANT 400, Ibuprom, Faspik, Solpafleks, Advil.

Generics of dosage forms for outside therapy are drugs of Dolgit, Ibalgin, the Nurofen, Ibuprofen-Verte.

Ibuprofen or Nurofen — what is better?

The nurofen is a medicine on the basis of an ibuprofen. That is drugs are generics. They are distinguished from each other by the producer, the price and structure of auxiliary components.


  • Ibuprofen of 200 mg No. 50 tabletkiborisovsky ZMP
  • Ibuprofen of 200 mg No. 20 tabletkisintez AKO of joint stock company
  • Ibuprofen of 200 mg No. 10 of a tabletkitatkhimfarmpreparata of joint stock company
  • Ibuprofen-hemofarm 400 mg No. 30 tabletkikhemofarm A.D.
  • Ibuprofen-hemofarm 200 mg No. 10 ship.tabletkikhemofarm A.D.

Drugstore of IFC

  • Ibuprofen tbl p / about 200 mg No. 20 *, Tatkhimfarmpreparata (Kazan) Russia
  • Ibuprofen-Akrikhin susp. fl 100mg/5ml 100 ml, Medana Pharma Terpolpolsha
  • Ibuprofen of 5% gel 50 of *, Zaorossiya's Vertexum
  • Ibuprofen tbl p / about 200 mg No. 20, Biosynthesis (Penza) Russia
  • Ibuprofen suppositories for children of 60 mg No. 10, Ooorossiya's Altfarm
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  • Ibuprofenborshchagovsky HFZ (Ukraine, Kiev)
  • Ibuprofentekhnolog (Ukraine, Uman)
  • Ibuprofenstirolbiofarm (Ukraine, Horlivka)


  • Tab. ibuprofen p / about 200 mg No. 50borshchagovsky of HFZ
  • Tab. ibuprofen p / about 200 mg No. 50borshchagovsky of HFZ


  • Ibuprofen of 200 mg No. 10 tabl.p.o. Borisovsky ZMP (Belarus)
  • Ibuprofen-ratiofarm 400 mg No. 20 tabl.p.o.
  • Ibuprofen-ratiofarm 400 mg No. 50 tabl.p.o.
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Section: Anesthetics
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use the Ibuprofen surely consult with the attending physician.