Ирифрин Drug photo

The description is actual on 20.06.2014

  • Latin name: Irifrin
  • ATH code: S01FB01
  • Active ingredient: Fenilefrin (Phenylephrine)
  • Producer: PROMED EXPORTS, Pvt. Ltd. (India)


Rolled into one Irifrina of 10% contains hydrochloride Phenylephrinum — 100 mg, and rolled into one Irifrina of 2,5% — 25 mg.

Excipients: chloride a benzalkoniya, edetat dinatrium, sodium hydroxide, a hydrosodium phosphate dihydrate, anhydrous dihydrosodium phosphate, sodium metabisulphite, citric acid, a sodium citrate dihydrate, the water purified.

One bottle of Irifrin WP (without preservative) of 2,5% contains Phenylephrinum hydrochloride — 25 mg.

Release form

Drops eye Irifrin represent transparent colourless or light yellow solution. 5 ml of such solution in a bottle dropper or a bottle from a tinted glass, one such bottle dropper or a bottle from a tinted glass in a cardboard pack.

Irifrin BK is issued in tubes droppers on 4 ml, 5 such tubes in a paper bag, 3 such bags in a cardboard pack.

Pharmacological action

Irifrin – the drops possessing alpha adrenomimeticheskim action: vasoconstriction, reduction of smooth muscles.

Pharmacodynamics and pharmacokinetics


Phenylephrinum is adrenomimetiky, possessing alpha and adrenergic activity. At reception in usual doses has no the stimulating effect on the central nervous system.

At local use stimulates outflow of intraocular liquid in ophthalmology, narrows vessels of a conjunctiva and causes a mydriasis (mydriasis).

Phenylephrinum possesses a strong promoting effect on alpha adrenoceptors in post-synapses, has insignificant effect on beta adrenoceptors of area of heart, it almost has no positive inotropic and chronotropic impact. Drug possesses the vasopressor (vasoconstrictive) action similar to action of noradrenaline, however at Phenylephrinum it is weaker also longer.

Vasoconstriction comes through 30-90 from later use, action duration — 2-5 hours.
After introduction (instillation) Phenylephrinum promotes reduction of the dilator of a pupil, causing a mydriasis. The mydriasis is reached within 20-60 min. after an instillation; 10% of solution — proceed 3-5 hours after an instillation of 2,5% of solution within 2 hours.


Phenylephrinum freely gets into fabrics of an organ of sight. The maximum concentration in blood comes in 10–20 minutes after local use. Preliminary instillation of anesthetics increases absorption in a system blood stream and prolongs a mydriasis. Drug is removed with urine in an original form (less than 20%) and in the form of inert metabolites.

Indications to use

  • Need of a mydriasis at ophthalmologic diagnostic procedures (control of a back piece of an eye).
  • Iridocyclitis (prevention of emergence of back synechias and weakening of exudation in an iris).
  • Carrying out provocative research at persons with a narrow corner of an anterior chamber and possible closed-angle glaucoma.
  • In surgical ophthalmology by presurgical preparation for the purpose of a mydriasis.
  • Differential diagnosis of a deep and superficial injection of an eye.
  • Therapy of glaukomotsiklitichesky crises.
  • Performance of laser interventions at the bottom of an eye and in vitreoretinalny surgery.
  • Therapy of a syndrome of "a red eye" (for weakening of a hyperemia and sensitivity of eye covers).
  • Inside and locally: for reduction of hypostasis mucous nasopharynxes and conjunctivas at allergic and catarrhal diseases (as a part of the combined treatment; only for Irifrina BK).
  • Parenterally: for increase in arterial pressure at a collapse and the hypotension caused with decrease in a tone of vessels (only for Irifrina BK).


  • Allergy to drug components.
  • Closed-angle or narrow angle glaucoma.
  • Diabetes mellitus.
  • Heavy disturbances of cardiovascular system (arterial hypertension, heart troubles, aneurism, tachycardia).
  • Thyrotoxicosis, hyperthyroidism.
  • Use together and within 14 days after the therapy termination by MAO inhibitors.
  • Mydriasis during an operative measure at patients with defect of integrity of an eye or at disturbance of outflow of the lacrimal liquid.
  • Simultaneous use with tricyclic antidepressants, anti-hypertensive drugs (including with beta-blockers).
  • Inborn shortcoming glyukozo-6-fosfatgidrogenazy.
  • Porphyria.
  • Newborns with a small weight.

Side effects

  • From eyes: conjunctivitis, hypostasis of fabrics of periorbital area; the burning sensation, irritation, a sight zatumanennost, dacryagogue, a sensation of discomfort, strengthening of intraocular pressure are possible.
  • After administration of drug Irifrin emergence of a reactive miosis is possible. At a drug reuse at this time the mydriasis is usually less expressed. This effect is characteristic of elderly people.
  • From cardiovascular system: feeling of heartbeat, tachycardia, reflex bradycardia, arrhythmia, arterial hypertension, occlusion of coronary arteries of heart, embolism of a pulmonary artery.
  • Because of strong reduction of the dilator of the pupil caused by action of Phenylephrinum in 35-45 minutes after use in a cavity of an anterior chamber fine grains of a pigment from an iris leaf can appear. This suspension needs to be differentiated with a front uveitis or with existence of blood cells of a cavity of an anterior chamber.
  • From skin: dermatitis.
  • Very seldom at Irifrin's use (drops for eyes of 10%) emergence of the heavy disturbances including a vascular collapse, a myocardial infarction and intracerebral bleeding is observed.

Eye drops Irifrin, application instruction

The instruction on Irifrin orders to use drops locally.

At an oftalmoskopiya single use of 2,5% of solution is used. For emergence of a mydriasis there is enough instillation of one drop of Irifrin of 2,5% in a conjunctival sac. Expansion a zrvchka of the maximum force is reached in 20–30 minutes and lasts for 1–3 hours. If necessary extension of a mydriasis is possible what in an hour one more instillation is made for.

At children of 12 flyings and adults at a weak mydriasis for provoking of a diagnostic mydriasis use of 10% of solution without correction of a dose is proved.

When carrying out diagnosis single use of 2,5% of solution can be used for:

  • the provocative test at persons with a narrow corner of an anterior chamber and possible closed-angle glaucoma;
  • differential diagnosis of a type of an injection of an eye (superficial or deep);
  • iridocyclitis solution 2,5 or 10 of % is applied to the prevention of development and a gap, the appeared back synechias; for reduction of exudation in the anterior eye chamber (one drop of Irifrin instillirutsya in a conjunctival sac 2–3 times a day);
  • stoppings of glaukomotsiklitichesky crises. Fenilefrin has hypotensive effect at this pathology. 10% solution are used 2–3 times a day;
  • training of patients for operative measures in 40–60 minutes single introduction of 10% of solution is made for achievement of a mydriasis; after disturbance of integrity of covers of an eye the reuse of drug is forbidden.

10% solution cannot be used for treatment of tampons during surgical intervention.

Irifrin BK is also used:

  • at a hypermetropia with tendency to a spasm of the accommodation which is followed by high loading approximately — drug is dug in in the evening together with 1% solution of a tsiklopentolat. At standard visual loading Irifrin BK use before going to bed 3 times a week;
  • at treatment of a true and false myopia — 1 drop before going to bed every 3 day within one month.


Overdose symptoms: manifestation of system effect of Phenylephrinum.

Treatment: reception of alpha adrenceptor blocking agents, for example 5-10 mg of phentolamine intravenously is recommended.


The mydriasis amplifies when sharing Phenylephrinum and atropine.

Use of 2,5 or 10% of solution of drug with MAO inhibitors and within three weeks after their cancellation, has to be carried out with care as in this case perhaps uncontrollable increase of arterial pressure.

 Irifrin's use 10% in combination with beta adrenoblockers can provoke an acute arterial hypertension.

Use together with sympathomimetics can strengthen cardiovascular action of Phenylephrinum.

Terms of sale

Drug is released strictly according to the recipe of the doctor.

Storage conditions

To protect from children. To store in the dark place, at a temperature up to 25 °C.

Period of validity

Two years.

Special instructions

As duration of a mydriasis can reach 1-3 hours at patients there can be a feeling of a photophobia therefore, before sight function recovery, it is necessary to protect eyes from a strong sunlight. Reading and viewing of telecasts are prohibited.

Development of the reactive miosis which more often is observed at elderly people after use of Phenylephrinum is possible, and the reuse of means leads to weakening of a mydriasis.

As drug as preservative contains chloride a benzalkoniya, it can cause decolorization of soft contact lenses. Before Irifrin's use the patient needs to remove lenses and to wait 15 minutes after instillation before again to use them.

Irifrin's analogs

Coincidence on the ATH code of the 4th level:

    In worthless time the following analogs of eye drops Irifrin are most widespread:
    Phenylephine hydrochloride, Nazol Bebi, Nazol Kids, Fenefrin of 10%.


    • Irifrin of 2,5% of a drop eye 5 ml bottle-kapelnitsapromed of Exports/Sentiss of Farm of Pvt. Ltd.
    • Irifrin of BQ of 2,5% of a drop eye 0,4ml No. 15 tube-kapelnitsypromed of Exports/Sentiss of Farm of Pvt. Ltd.

    Drugstore of IFC

    • Irifrin BK of a hl drop. 2.5% 0,4ml tube dropper, No. 15, Promed Exportsindiya
    • Irifrin of a hl drop. 2.5% of 5 ml, Promed Exportsindiya
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    • Irifrinpromed Exports (India)


    • Irifrin of 2,5% 5 ml of a drop glazn.sentiss Pharma Private Limited (India)
    to show still
    Section: For eyes
    in more detail

    Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

    Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

    Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
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