Итомед Drug photo

The description is actual on 25.03.2015

  • Latin name: Itomed
  • ATH code: A03FA
  • Active ingredient: Itoprid (Itopride)
  • Producer: PRO.MED.CS Praha a.s. (Czech Republic)


Itoprida of a hydrochloride of 50 mg.

Lactoses monohydrate, magnesium stearate, starch corn, croscarmellose sodium, silicon dioxide as excipients.

Release form

Tablets in a film cover.

Pharmacological action

Antiemetic, stimulating motility of a gastrointestinal tract.

Pharmacodynamics and pharmacokinetics


Prokinetic which has effect on the gastrointestinal tract motor function. Interferes with antiperistaltic reductions of muscles. Has the combined action mechanism which consists in interaction with D2 - dopamine receptors and acetylcholinesterase blocking. Interferes with destruction of acetylcholine and activates its release. It causes strengthening of motility of a gastrointestinal tract throughout all digestive channel: accelerates passing of food on a stomach and intestines, improves their emptying.

The antiemetic effect is connected with interaction of an itoprid with D2 receptors which are in a trigger zone (a bottom of the fourth cerebral cavity). Suppresses vomiting which is caused by Apomorphinum and this effect has dozozavisimy character.

Advantage is low ability to get through GEB, in this regard there are no extrapyramidal and neuroendocrinal effects. Does not change concentration of hormone of gastrin in serum.


It is quickly soaked up in a gastrointestinal tract. Bioavailability of 60%. The food does not influence bioavailability of drug. The maximum concentration — in 0,5 hours. At repeated receptions within 7 days cumulation is minimum.

For 96% contacts proteins. It is well distributed in fabrics and in high concentration it is found in a small intestine, a stomach, kidneys, a liver and adrenal glands. Slightly gets into a brain.

It is metabolized in a liver to 3 metabolites, one shows insignificant activity. Itoprid has no effect on CYP2C19 and CYP2E1. Elimination half-life of 6 hours. It is removed by kidneys.

Indications to use


  • mechanical perforation of a gastrointestinal tract;
  • bleedings from a digestive tract;
  • deficit of lactase;
  • glucose galactose absorption disturbance;
  • pregnancy;
  • feeding by a breast;
  • hypersensitivity to drug;
  • age till 16 flyings.

Itomed with care has to be appointed to patients with the expressed abnormal liver function and kidneys.

Side effects

  • small tortoiseshell, acute anaphylaxis;
  • headache, irritability, sleeplessness, tremor;
  • leukopenia, thrombocytopenia;
  • gynecomastia, giperprolaktinemiya;
  • plentiful salivation, nausea, pain in epigastriums, jaundice, diarrhea or a lock;
  • increase of activity of transaminases, hyperbilirubinemia.

Itomed, application instruction (Way and dosage)

Drug is accepted inside, to food. A dose for adults — 50 mg 3 times. Daily dose of 150 mg. For elderly people the dose decreases.

The application instruction of Itomed contains the prevention concerning if time of administration of drug is passed. In that case it is not recommended to accept a double dose and further to accept as usual.


It is shown by strengthening of side reactions. The gastric lavage is undertaken and the symptomatic treatment is appointed.


Itomed accelerates absorption of other drugs as increases motility of a stomach. This fact has to be considered at purpose of the HP having the slowed-down release of active ingredient or low bioavailability.

Cholinergic effect of drug increases at joint reception of m cholinomimetics and inhibitors of cholinesterase.

M-holinoblokatory (Gastril, Gastrozem, Gastrotsepin, Hyoscine) lower efficiency of an itoprid. The means reducing acidity of a gastric juice do not influence its activity.

Antiulcerous means (Cimetidinum, Ranitidine, Tsetraksat) do not make impact on pro-kinetic effect of an itoprid.

At joint appointment with Warfarin, Diazepam, Nifedipine, Diclofenac, Tiklopidin linkng with proteins does not change.

Terms of sale

It is released according to the recipe.

Storage conditions

At a temperature up to 25 °C.

Period of validity

3 years.

Itomed's analogs

Coincidence on the ATH code of the 4th level:

Analogs Itomeda Ganaton, Itopra, Itoprid have one active ingredient and a form of release.

About Itomeda

In spite of the fact that this drug in an arsenal of doctors about 15 flyings, About Itomeda at forums meet seldom. Nevertheless, is About its use at chronic a reflux esophagites and GERB. Against treatment reduction of heartburn, abdominal distention and feeling of weight in a stomach was noted, appetite improved. Treatment was carried out 6 - 8 weeks. There are About effective treatment these drug of chronic locks.

In general, drug is characterized by good tolerance and serious side effects were absent. Most often diarrhea, abdominal pains, a headache met. There is one message that Itomed caused an amenorrhea.


  • Itomed of 50 mg No. 100 of a tablet
  • Itomed of 50 mg No. 40 of a tablet

Drugstore of IFC

  • Itomed tbl p / about captivity. 50 mg No. 100, Pro.Med.CS Prahachekhiya
  • Prostatilen soup rekt. 30 mg No. 10, Npkrossiya's Cytohoney
  • Vitaon-Lyuks Karavayev's balm fl 25 ml for skin, Litomed of Ltd company (Moscow) Russia
  • Itomed tbl p / about captivity. 50 mg No. 40, Pro.Med.CS Prahachekhiya
  • Vitaon Karavayev's balm fl 25 ml, Litomed of Ltd company (Moscow) Russia
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  • Itomed of 50 mg No. 40 Praha a.s. (Czech Republic)
  • Itomed of 50 mg No. 100 Praha a.s. (Czech Republic)
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Section: Gastrointestinal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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