Itrakon

Итракон Drug photo

The description is actual on 12.07.2016

  • Latin name: Itracone
  • ATH code: J02AC02
  • Active ingredient: Itrakonazol (Itraconazole)
  • Producer: CJSC Farmak (Ukraine)

Structure

In 1 capsule — 100 mg of an itrakonazol. Gipromeloza, gelatin, sucrose, dyes, as auxiliary components.

Release form

Gelatinous capsules No. 15.

Pharmacological action

Antifungal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Shows activity concerning dermatophytes, barmy fungi, Blastomyces dermatitidis, Paracoccidioides brasiliensis, Aspergillus spp., Fonsecaea spp., Sporothrix schenckii, Cladosporium spp. The mechanism of action is caused by ergosterol synthesis braking — the basic making membranes of cells of a pathogenic fungi. Decrease in its products attracts death of mushrooms.

Pharmacokinetics

Bioavailability at intake amplifies after meal. Cmax in blood is noted in 3-4 hours. Constant concentration is created at reception within two weeks. Communicates blood proteins for 99,8%. Collects in fabrics which contain a keratin, and concentration of active agent in them is 4 times more, than in plasma.

Removal from fabrics depends on the speed of regeneration of epidermis. Medical concentration in skin remains 2-4 more weeks. In a nail keratin after a three-months course of treatment concentration remains 6 months. Tissues of a vagina keep therapeutic level 2 more days after a three-day course. It is metabolized in a liver to a large number of metabolites. It is removed with urine and a stake.

Indications to use

Contraindications

  • Hypersensitivity;
  • acute heart failure;
  • simultaneous use with drugs which are metabolized with the participation of CYP 3A4 enzyme;
  • concomitant use with ergot alkaloids (dihydroergotamine, ergotamine, ergometrine, methylergometrine).

With care it is necessary to appoint at cirrhosis, a chronic heart and renal failure, to elderly patients and children.

Side effects

  • Nausea;
  • meteorism;
  • abdominal pains;
  • toxic damage of a liver;
  • headache;
  • skin itch;
  • anaphylactic reactions;
  • small tortoiseshell;
  • papular rash;
  • leukopenia, thrombocytopenia;
  • paresthesias, neuropathy;
  • vision disorder, opacification before eyes;
  • sonitus, temporary hearing loss;
  • mialgiya and arthralgias;
  • urine incontience;
  • frustration of a menstrual cycle.

Itrakon, application instruction (Way and dosage)

Capsules accept inside, without chewing, after food.

Vulvovaginal candidiasis — 2 capsules once a day, three days in a row.

Dermatomycoses, chromophytosis – on 2 capsules daily 7 days.

Oral cavity candidiasis — on 1 capsule a day 15 days.

Epidermophitia of feet and brushes — on 2 capsules 2 times a day, week.

Fungal keratitis — on 2 capsules of times a day 3 weeks.

Onychomycoses — on 2 capsules a day three months.

Overdose

Cases of overdose are not known. At accidental overdose the gastric lavage is undertaken. The antidote does not exist. It is removed by a hemodialysis method.

Interaction

Reception with rifampicin, Phenytoinum and rifabutiny is followed by decrease in efficiency of drug. Increase bioavailability of an itrakonazol ritonavir, klaritromitsin, indinavir, erythromycin. Strengthening of negative inotropic effect is noted at reception of blockers of calcium channels. Itrakonazol does not interact with fluvastatiny and a zidovudine, does not influence an ethinylestradiol metabolism.

Terms of sale

According to the recipe.

Storage conditions

Temperature is up to 25 °C.

Period of validity

2 years.

Itrakon's analogs

Orungal, Itrakonazol, Orunit, Irunin, Itrazol, Kanditral — have the same active ingredient.

About Itrakona

At long and heavy fungal infections resort to system therapy – appoint drug inside. Itrakon — the most active drug from azoles, and in comparison with other antimycotics has the greatest number of indications to use. Itrakon's use is effective at candidiasis of skin and mucous, an inguinal epidermophitia, deep mycoses: koktsidiomikoz, zymonematosis, foot mycetoma, sporotrichosis, histoplasmosis, aspergillosis.

In responses of patients the fact that drug was appointed at persistent fungal infections of feet and hands within 30 days is noted.  Pulse therapy is often used in the form of the 2nd stage — it reduces risk of side effects. At a fungal infection of nails it was accepted on 200 mg by 2 times a day week and repeatedly the same course in 21 days.

  • "… At a fungus of a nail Itrakon inside and ointment Lamizil outwardly took a pill. The doctor told that it is drugs of different groups and they can be applied together. Within 2 months the new healthy nail grew".
  • "… At the milkwoman who at me is periodically shown wrote out Itrakon, after him any more half a year is not present the milkwoman".
  • "… To two weeks to me appointed this drug at candidiasis mucous a mouth. Propyl, everything passed, and before month there were yazvochka in a mouth".

Effective was a treatment of patients with a common form of a chromophytosis with frequent recurrence.

Zdravzona

  • Itrakonazol of 100 mg No. 14 kapsulybioky closed joint stock company
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Apteka24

  • Itrakonazol15
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  • Itrakonazol of a capsule of 100 mg No. 4rusan of Farm (India)
  • Itrakon of a capsule of 100 mg No. 15farmak (Ukraine, Kiev)
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Paniapteka

  • Itrakon kaps. 100 mg No. 15farmak
  • Itrakon kaps. 100 mg No. 15farmak
  • Itrakon kaps. 100 mg No. 15farmak

BIOSPHERE

  • Itrakon of 100 mg No. 15 kaps. Farmak (Ukraine)
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Section: Antifungal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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