Itrakonazol

Итраконазол Drug photo

The description is actual on 28.04.2015

  • Latin name: Itraconazole
  • ATH code: J02AC02
  • Active ingredient: Itrakonazol
  • Producer: Biolump of closed joint stock company (Russia), Atoll (Russia), Sandoz (Slovenia)

Structure

As a part of a capsule active agent itrakonazol 100 mg contains

Additional components: gelatin, dye, titanium dioxide.

Release form

Capsules.

Pharmacological action

Antifungal means.

Pharmacodynamics and pharmacokinetics

Active agent is derivative triazole. It is made in the synthetic way, possesses a wide range of influence.

The antifungal mechanism is based on suppression of development, synthesis of ergosterol in a mushroom cell. It is active against mold mushrooms, dermatophytes, barmy mushrooms.

Efficiency of antifungal therapy is estimated in a month after completion of treatment (at mycoses). At onychomycoses efficiency is estimated in process of change of a nail plate (6-9 months).

Indications to use

Itrakonazol in capsules appoint at multi-colored herpes, dermatomycoses, keratomycoses, system mycoses, candidiasis of an oral cavity, vulvovaginal candidiasis, a cryptococcosis, a system aspergillosis, histoplasmosis, a parakoktsidiodoza, a sporotrichosis, a zymonematosis, tropical mycoses.

Contraindications

Itrakonazol do not appoint at simultaneous use of midazolam, triazolama.yu a nisoldpin, alkaloids of an ergot, substrates of an isoenzyme CYP3A4, intolerance.

Medicine is not appointed when feeding a breast, during pregnancy incubation.

Side effects

Itrakonazol can cause allergic reactions, thrombocytopenia, a serum disease, a leukopenia, anaphylactoid reactions, a gipertriglitseridemiya, a hypopotassemia.

Nervous system: hyperesthesia, paresthesia, dizzinesses, peripheral neuropathy.

Respiratory system: fluid lungs.

Digestive tract: diarrhea, dispepsichesky frustration, a hepatotoxic, increase of enzymes of hepatic system, vomiting, locks, hepatitis, disturbance of flavoring perception, a hyperbilirubinemia, pains in epigastriums.

Sense bodys: sonitus, constant deafness, illegibility of visual perception, diplopia.

Development of an arthralgia, mialgiya, incontience of urine, pollakiuria, erectile dysfunction, menstrual disturbances, puffinesses is possible.

Tablets Itrakonazol, application instruction (Way and dosage)

Accept inside, desirable time of reception – after food.

Vulvovaginal candidiasis: twice a day on 200 mg, or 3 days on 200 mg once a day.

Dermatomycoses: 7 days on 200 mg a day, or 15 days on 100 mg once a day.

Chromophytosis: 7 days on 200 mg daily.

Oral cavity candidiasis: 15 days on 100 mg daily.

At mycoses on skin plates of brushes antifungal therapy is carried out twice with an interval of three weeks. The elimination from nail plates and skin is carried out slowly.

The application instruction of Itrakonazol at a system aspergillosis: 2-5 months on 200 mg every day.

Overdose

Cases are not recorded.

Interaction

Absorption of drug is broken at simultaneous receipt in an organism of medicines which reduce acidity of a gastric juice. Phenytoinum, rifampicin, rifambutin and other inductors of an isoenzyme CYP3A4 worsen bioavailability of antifungal means. Inhibitors of this enzyme render a converse effect. At co-administration of BMKK, antineoplastic means (trimetreksat, dotsetakset, busulfan, periwinkle alkaloids), immunodepressants (sirolimus, takrolimus), GKS, digoxin, indirect anticoagulants it is necessary to be careful.

Terms of sale

The recipe is required.

Storage conditions

In the place, dry, dark, unavailable to children, at a temperature of 15-25 degrees Celsius.

Period of validity

No more than two years.

Special instructions

Prevention of reinfection consists in simultaneous antifungal therapy of all contacting sexual partners, careful observance of rules of personal hygiene. Antifungal treatment means abstention from sex life throughout all course of therapy.

If after completion of antifungal therapy symptoms of a disease remain, then conduct repeated microbiological examination for confirmation of correctness of the diagnosis. At a heavy current of a neutropenia Itrakonazol appoint at inefficiency of the first line of therapy.

At detection of risk factors of HSN (the expressed puffiness, defeat of valves of heart, an ischemic heart disease, heavy pathology of pulmonary system, HOBL) antifungal therapy is stopped. Use of antifungal drug can cause deafness (passing and constant forms).

Itrakonazol's analogs

Analogs are drugs: Izol, Ikonazol, Itrazol, Itrakon, Itral, Itrasin, Itrungar, Metriks, Mikokur, Mikostop, Orungal, Orunzol, Sporagal, Sporaksol, Trioksal, Funit, Eszol.

Zdravzona

  • Itrakonazol of 100 mg No. 14 kapsulybioky closed joint stock company
to show still

Apteka24

  • Itrakonazol15
  • Itrakonazol4
  • Itrakonazol of a capsule of 100 mg No. 4rusan of Farm (India)
Section: Antifungal
in more detail

Education: Graduated from the Bashkir state medical university majoring in "Medical business". In 2011 gained the diploma and the certificate in Therapy. In 2012 received 2 certificate and the diploma in "Functional diagnosis" and "Cardiology". In 2013 completed courses on "Topical issues of otorhinolaryngology in therapy". In 2014 completed advanced training courses in "A clinical echocardiography" and courses in "Medical rehabilitation".

Experience: From 2011 to 2014 the Policlinic No. 33 Ufa worked as the therapist and the cardiologist in MBUZ. Since 2014 the Policlinic No. 33 Ufa works as the cardiologist and the doctor of functional diagnosis in MBUZ.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Itrakonazol surely consult with the attending physician.