Potassium Chloride

Калия Хлорид Drug photo

The description is actual on 01.07.2015

  • Latin name: Potassium chloride
  • ATH code: B05XA01
  • Active ingredient: Potassium chloride
  • Producer: JSC Dalkhimfarm (Russia)

Structure

1 milliliter of drug can include 30, 40, 75 or 150 mg of potassium chloride – active ingredient.

Additional ingredients: water for infection to 1 ml; 0,1 M of Acidum hydrochloricum to rn 3-4.

Chemical formula – KCl.

Release form

The Dalkhimfarm company lets out Potassium drug Chloride in the form of a concentrate for further infusional use, in bottles on 100 or 200 ml.

Pharmacological action

Compensating for the potassium deficiency.

Pharmacodynamics and pharmacokinetics

According to Wikipedia solution of potassium chloride is intended for recovery of water and electrolytic balance. In moderate doses drug possesses negative bathmotropic and chronotropic impact, in higher dosages is characterized by negative dromotropic and inotropic efficiency, and also shows so-so the expressed diuretic (diuretic) action.

Introduction of small doses of drug of potassium promotes expansion of coronary vessels, and use of big dosages to their narrowing. Use of drugs of potassium strengthens transfer of nervous intercellular impulses, and in case of intravenous administration promotes increase in allocation by adrenaline adrenal glands.

Drug activates a large amount of cytoplasmatic enzymes, adjusts the osmotic intracellular pressure, replication of proteins, contractility of muscles of a skeleton and transportation of amino acids. Reduces conductivity, ChSS, sokratitelny activity, excitability and automatism of a myocardium. Increase in maintenance of this microelement in an organism lowers possibility of toxic effects of cardiac glycosides.

Indications to use

Use of Potassium chloride is shown at:

Contraindications

Side effects

Application instruction of Potassium chloride

In case of diagnosing of indications to drug use, appoint Potassium Chloride intravenously struyno, using potassium chloride in ampoules, or infusionally (kapelno) together with a dextrose (5% solution).

At intoxication glycosides is shown to enter chloride potassium in a daily dosage 2-3 grams, in case of serious intoxication — to 5 grams.

At the hypopotassemia passing with disturbances of a heart rhythm appoint 1-1,5 grams of 4-5 times at 24 o'clock, about reduction of a dosage after recovery of a heart rhythm.

In case of incessant vomiting or displays of heavy intoxication which demand immediate elimination use 4% the solution divorced in 40% to glucose. 50 ml of drug dissolve in is tenfold to the exceeding dose (500 ml) of water for infection and enter in the form of infusion with a frequency of 20-30 of cap/min. Also, introduction infusionally at the rate of 2,5 grams in 500 ml of 5% of a dextrose or 0,9% of sodium chloride is possible.

For leveling of a Bouveret's disease use in the first days 8-12 grams of drug, with further lowering of a dosage to 3-6 grams.

For the purpose of prevention or therapy of ectopic arrhythmias in the acute period of a myocardial infarction prepare the polarizing mix for what potassium chloride is dissolved in 5-10% to a dextrose with addition of insulin of short action (1 PIECE on 3-4 grams of a dry dextrose).

Overdose

At overdose observed the hyperpotassemia which is characterized by the following symptoms: hypotone of muscles, paresthesia of extremities, arrhythmia, braking of atrioventricular conductivity, cardiac standstill. The first manifestations of a hyperpotassemia, as a rule arise at serumal potassium concentration more than 6 mekv/l (loss of a tooth of U if it was present at the previous cardiograms; allocation of a tooth of T; lengthening of an interval of Q-T; reduction of the S-T segment; increase in the QRS complex. Serious symptomatology of a hyperpotassemia (muscular paralysis and a cardiac standstill) form at plasma contents 9-10 mekv/l.

For stopping of this state appoint in/in introduction 0,9% of sodium chloride and 300-500 ml of 5% of a dextrose with content of insulin in it (10-20 PIECES/litre). In case of need carry out a peritoneal dialysis and a hemodialysis.

Interaction

Increases negative bathmotropic and dromotropic efficiency of antiarrhytmic HP.

At parallel use with cardiac glycosides promotes improvement of their portability.

Combined use of Cyclosporine, Heparin, beta adrenoblockers, kaliysberegayushchy diuretics, APF, NPVS inhibitors can strengthen a possibility of forming of a hyperpotassemia.

Terms of sale

According to a pharmacopeia Potassium medicine issue Chloride is carried out according to the recipe.

Storage conditions

Bottles with solution keep the properties at a surrounding temperature from 15 to 25 °C.

Period of validity

From the moment of production – 1 year.

Special instructions

It is necessary to consider that the food containing a large amount of sodium strengthens removal from a potassium organism.

Throughout use of drug it is necessary to exercise control over the serumal maintenance of potassium ions and to carry out the electrocardiogram.

At treatment of symptomatology of a hypopotassemia it is necessary to control an acid-base condition of an organism.

It is necessary to remember that the heavy hyperpotassemia which can become the reason of a lethal outcome develops asymptomatically and quickly enough.

Use of chloride potassium as fertilizers

Except use of chloride potassium in medicine it is widely applied in the industry (production of leather substitutes, rubber and so forth), and also in agriculture as fertilizer. GOST 4568 95 (state standard) regulates all regulations on production, outward, packaging, health requirements, ways and methods of use, etc. of technical and agricultural potassium.

Use of chloride potassium in gardening and truck farming, except saturation of the soil, has a number of the positive moments and for plants, such as: increase in productivity, increase of resistance to frosts, diseases, drought, wreckers, increase in period of storage and outward of fruits and tubers, decrease in contents in them in nitrates and radionuclides. The main sphere of influence are long-term fruit berry plants, vegetable cultures and decorative plantings.

Analogs

Analogs of drug, on the ATX code to the fourth sign, solutions are: Calcium chloride and Sodium chloride, Ksilat, Glyuksil, Magnesium sulfate, Laktoksil, Soda-Bufer, Reamberin, etc.

Zdravzona

  • Potassium chloride of 4% solution for injections of 10 ml No. 10 ampulymikrogen NPO Federal State Unitary Enterprise
  • Potassium chloride bufus 4% a concentrate for Preeg. solution for infusions of 10 ml No. 10 ampulyobnovleny PFK of closed joint stock company
  • Potassium chloride of 4% solution for injections of 5 ml No. 10 ampulydalkhimfarm joint stock company

Drugstore of IFC

  • Potassium chloride solution for in 4% 10 ml No. 10, the Slavic drugstore of Ltd company (г.Москва) Russia
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Apteka24

  • Potassium chloride

BIOSPHERE

  • Potassium chloride 4%/10 of ml No. 10 solution for in.amp. JSC Novosibkhimfarm (Russia)
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Section: Others Cardiological Cardiovascular
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Education: Graduated from the Vinnytsia national medical university of N. I. Pirogov, pharmaceutical faculty, the higher pharmaceutical education – the specialty "Pharmacist".

Experience: Work in Koneks and Bios-Media pharmacy chains as "Druggist". Work as "Pharmacist" in Avicenna pharmacy chain of the city of Vinnytsia.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before Potassium medicine use Chloride surely consult with the attending physician.