D3 calcium Nikomed

Кальций Д3 Никомед Drug photo

The description is actual on 06.03.2015

  • Latin name: Calcium-D3 Nycomed
  • ATH code: A12AX
  • Active ingredient: Calcium carbonate (Calcium carbonate) + Cholecalciferol (Cholecalciferol)
  • Producer: Nycomed Pharma (Switzerland)

Structure D3 Calcium Nikomed

Composition of 1 chewable tablet:

  • calcium carbonate – 1250 mg (in terms of elementary calcium – 500 mg);
  • cholecalciferol – 5,0 mkg that there correspond 200 international units;
  • sorbitol – 390 mg;
  • izomalt – 62,0 mg;
  • povidone – 36,4 mg;
  • magnesium stearate – 6,00 mg;
  • aspartame – 1,0 mg;
  • orange oil in number of 0,97 mg or a mint flavoring additive weighing 31,9 mg;
  • mono and diglycerides of fatty acids – 0,0008 mg.

Structure D3 Calcium Nikomed Forte (1 tablets for chewing):

  • calcium a carbonate – 1250 mg (500 mg of elementary calcium are equivalent);
  • D3 vitamin (cholecalciferol) – 10 mkg (400 ME);
  • sorbitol – 390 mg;
  • izomalt – 49,9 mg;
  • povidone – 36,4 mg;
  • magnesium stearate – 6 mg;
  • aspartame – 1,0 mg;
  • lemon oil – 0,78 mg;
  • mono and diglycerides of fatty acids – 0,0006 mg.

Release form

  • The orange or mint D3 Calcium chewable tablets Nikomed white color which do not have a cover, a biconvex, round form with the corresponding aroma. Existence of small dot impregnations and uneven edges is allowed. Tablets in bottles from polyethylene of high density on 20,50 or 100 pieces are packed up. Cardboard packaging contains 1 bottle with medicine and the summary to drug.
  • Calcium Nikomed D3 Forte – round chewable tablets with aroma of a lemon. Biconvex tablets have no cover and are on sale in high density polyethylene bottles on 30, 60 and 120 pieces. 1 bottle and the application instruction of drug is put in a cardboard pack.

Pharmacological action

Medicine belongs to the combined pharmaceutical drugs which regulate an exchange of calcium and phosphorus in an organism and fill shortage of the basic structural element. The biochemical role of calcium lies in physiological creation of a bone tissue, a mineralization of teeth, processes of coagulation and transfer of nervous impulse, implementation of muscular contractions. In response to its increase in a system blood-groove density of a bone tissue increases, calcium excretion kidneys decreases.

Cholecalciferol is responsible for processes of absorption of an element in a digestive tract and its distribution in an organism. Oral administration of drug slows down parathormone synthesis – the natural hormone of epithelial body considerably influencing a phosphorus-calcium exchange. Respectively the amount of the soaked-up calcium from a digestive tube increases and its resorption (washing away) from bones and other bodies decreases.

Pharmacodynamics and pharmacokinetics

Calcium is soaked up from proximal department of a digestive tube in number of 30% of the accepted dose then the element gets to a system blood stream where 50% are in the active ionized form, that is active ingredient contacts citrates, phosphates, albumine and some other anions and proteinaceous structures. The main construction component Eliminirutsya by intestines, sweat glands and kidneys. When calculating excretion it is necessary to consider that renal removal of calcium depends not only on glomerular filtering, but also on a canalicular reabsorption.

D3 vitamin is absorbed mainly from a small bowel from where about 80% of the accepted dose where contacts specific transport globulin come to the main blood stream. The metabolism of cholecalciferol includes two stages – at first vitamin by a hydroxylation will be transformed to 25 hydroxycholecalciferol then, getting into kidneys, it is transformed to an active form – 1,25 hydroxycholecalciferol. Not changed vitamin stocks up with an organism in muscular and fatty tissue. Cholecalciferol by means of how much and intestines is removed.

Indications to use

  • prevention and complex treatment of osteoporosis;
  • deficit of calcium and/or D3 vitamin;
  • fractures of bones.

Contraindications

Absolute contraindications to use of pharmaceutical drug:

  • hypervitaminosis D;
  • hypercalcemia – increases of calcium in blood;
  • hereditary intolerance of fructose;
  • the immobilized patients;
  • hypercalcuria – emergence of calcium in urine;
  • glyukozo-galaktozny malabsorption;
  • nephrolithiasis and other diseases in which pathogeny it is noted formations of calcic concrements;
  • active form of tuberculosis;
  • renal failure;
  • fenilketonuriya;
  • sarcoidosis;
  • saccharose izomaltaznaya insufficiency;
  • hypersensitivity to the making components of medicine or to such food stuffs as soy and a peanut;
  • children's age till 3 flyings.

Side effects

The instruction on D3 Calcium Nikomed (A way and a dosage)

The application instruction of pharmaceutical drug specifies that medicine is used orally, and it is necessary to chew or rassasyvat tablets during food. For prevention of osteoporosis the dosage D3 Calcium Nikomed is used: 1 tablet 2 times a day or 2 tablets once a day. For the purpose of complex therapy of this morbid condition about 1 tablet of Sa D3 Nikomed 3 times a day is accepted. Duration of such treatment is appointed individually, proceeding from biochemical indicators of exchange processes and a condition of a bone tissue, teeth and derivatives of skin (hair and nails).

For elimination of scarce states duration of a course of treatment makes not less than 4-6 weeks, and the dosage surely considers an age category of the patient:

  • to children from 3 to 5 flyings – 1 or ½ tablets a day;
  • from 5 to 12 flyings – on 1-2 tablets a day;
  • to adults and teenagers 12 years – on 1 tablet 2 times a day are more senior.

The instruction on D3 Calcium Nikomed Forte differs only in a dosage of medicine and duration of a course of conservative therapy therefore at its appointment these aspects of medicamentous correction of a phosphorus-calcium exchange should be discussed in addition with the attending physician.

Overdose

In case of overdose by pharmaceutical drug symptoms which testify to a hypercalcemia develop:

  • anorexia;
  • dryness in a mouth, thirst;
  • muscular weakness;
  • nausea and other dispepsichesky frustration;
  • polyuria;
  • ostealgias;
  • mental disturbances;
  • nephrocalcinosis;
  • urolithiasis (at long increase of concentration of calcium of blood);
  • cardiac arrhythmias (in especially hard cases);
  • calcification of soft tissues;
  • organic lesions of kidneys.

At identification of symptoms of a surplus of calcium and D3 vitamin it is necessary to stop immediately reception of pharmaceutical drug, thiazide diuretics and cardiac glycosides (features of pharmacokinetics of therapeutic properties are specified in the section "Interactions") and to see the attending physician. As a rule, with the therapeutic purpose "loopback" diuretics (drug of the choice Furosemide is), peroral glucocorticosteroids, the Calcitonin, biphosphonates are appointed. At overdose it is necessary to control the following physiological indicators:

  • content of electrolytes in a blood plasma;
  • functional capacity of kidneys and diuresis;
  • central venous pressure;
  • electric action of the heart.

Interaction

At the combined use D3 Calcium Nikomed and cardiac glycosides potentiation of toxic effect of the last therefore in need of their simultaneous use careful control of an electrocardiography and concentration of calcium in blood is recommended is possible.

Calcium can reduce absorbtivny abilities of antibiotics of group of quinoline and a tetracycline row, and also left thyroxine, sodium fluoride, biphosphonates therefore these drugs should be accepted not earlier than before 2 hours to or 6 hours after use of medicines on the basis of physiological "builder" of bone system of an organism.

Glucocorticosteroids, barbiturates, laxative drugs, Phenytoinum and holestiramin reduce bioavailability of peroral therapeutic means, that is active components are soaked up in a digestive tract in smaller quantities therefore it is necessary to korrigirovat a dosage or the scheme of reception D3 Calcium Nikomed at the conservative sanitation assuming a medicine combination to other pharmaceutical products.

Thiazide diuretics in pharmacy sometimes are called saving as pharmaceutical drugs of this row brake a canalicular reabsorption of calcium and some other micro and macrocells owing to what regular control of calcium in blood serum in order to avoid a hypercalcemia and a condition of overdose is required.

The use of foodstuff which contains oxalates (a sorrel, potatoes, spinach, a rhubarb) or phytin (the majority of friable grain), reduces ability of calcium to be soaked up in a digestive tract therefore it is necessary to adjust a day diet in a special way. It is not necessary to accept pharmaceutical drug within four hours after food any of the listed above products.

Terms of sale

Sale of pharmaceutical drug means non-prescription dispensing in pharmaceutical booths.

Storage conditions

It is necessary to store medicine in densely closed bottle in the place, dry and unavailable to children. Temperature condition – is not above 25 degrees Celsius.

Period of validity

3 years

Special instructions

Brief information on the producer

Nikomed – the Swiss pharmaceutical company founded in far 1874 with headquarters in Zurich is also widely known thanks to such medicinal products as Pantoprazol, Actovegin and D3 Calcium. Till certain time entered into number 30 of the largest corporations of the world on sales volume in the market of conservative therapeutic means. In September, 2011 it was redeemed by the Japanese company Takeda, one of areas of interest of which are metabolic diseases and their correction by means of drug treatment. Therefore the official site Nikomed is nowadays provided by an Internet resource under management Takeda.

Influence of pharmaceutical drug on spheres of everyday life

D3 calcium Nikomed – the combined medicine with the designated selectivity of therapeutic action, that is active components of chewable tablets and their auxiliary components do not influence ability to concentration, long attention or on other spheres of everyday life. During passing of a course of treatment independent management of motor transport and work with technical difficult mechanisms is allowed.

Analogs D3 Calcium Nikomed

Medicine belongs to group of the combined drugs for regulation of calcic level in blood and the maintenance of a structural element in body tissues. Of course, there are various analogs of chewable tablets. As a rule, drugs are provided by directly biogenic component and excipients for fuller implementation of its therapeutic properties. So it should be noted:

  • Complivit — mainly used for a children's age category for prevention of deficit of calcium;
  • Ideos — the chewable tablets appointed at senile, age osteoporosis or its emergence owing to a menopause;
  • Natekal D3 — applied at the idiopathic progressing shortage of calcium and its complications in the form of fractures of bones or stomatologic problems.

These drugs are appointed if there are any absolute or relative contraindications to D3 Calcium Nikomed, for example, at hypersensitivity to his auxiliary components, in order to avoid a medicinal allergy or development of adverse effects of conservative therapy. The price of analogs D3 Calcium Nikomed is, as a rule, higher that gives unambiguous advantage to this pharmaceutical means for correction of a phosphorus-calcium exchange.

Kaltsemin or D3 Calcium Nikomed — what is better?

Kaltsemin is one of the most popular analogs D3 Calcium Nikomed. It is the combined pharmaceutical drug which composition includes calcium carbonate, D3 vitamin, copper oxide and zinc, manganese sulfate and sodium borate. Coated tablets are appointed not only at disturbances of a phosphorus-calcium exchange, but also for completion of deficit of some microelements having important biological value for normal functioning of an organism.

Dosage of calcium and cholecalciferol in Kaltsemin 10 times less than in the D3 Calcium chewable tablets Nikomed that causes smaller quantity of side effects, sharply reduced chance of overdose. But the composition of medicine also causes longer medicamentous course of therapy at osteoporosis therefore it is appointed mainly for children of teenage age and women at pregnancy or during a lactation. D3 calcium Nikomed, in turn, copes with the main objective much more effectively – settlement of a phosphorus-calcium exchange and elimination of the corresponding complications.

Zdravzona

  • Calcium d3 nikomed 500 mg + 200ME No. 50 chewable tablets myatanycomed Pharma
  • Calcium d3 nikomed forte 500 mg + 400ME No. 30 chewable tablets limonnycomed Pharma
  • Calcium d3 nikomed 500 mg + 200ME No. 100 chewable tablets apelsinnycomed Pharma
  • Calcium d3 nikomed 500 mg + 200ME No. 20 chewable tablets apelsinnycomed Pharma
  • Calcium d3 nikomed forte 500 mg + 400ME No. 60 chewable tablets limonnycomed Pharma
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Section: Vitamins
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Education: Kharkiv national medical university

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