Calcium gluconate

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The description is actual on 14.03.2016

  • Latin name: Calcium gluconate
  • ATH code: A12AA03
  • Active ingredient: Calcium gluconate (Calcium gluconate)
  • Producer: Moscow chemical pharmaceuticals of N. A. Semashko, Esky NPK of joint stock company, Dalkhimfarm, the Armavir biofactory, CJSC Binnofarm, Veropharm of joint stock company, Ellara of Ltd company, Medisorb (Russia)


One tablet can contain 250 or 500 mg of active agent.

Auxiliary components: potato starch, anhydrous silicon dioxide in a colloid form, calcium stearate.

Concentration of active agent in 1 ml of solution — 95.5 mg. 1 ml of drug of total calcium (Sa2+) contains 8.95 mg that in terms of the theoretical maintenance of a gluconate of calcium makes 100 mg/ml. As auxiliary components saccharate of calcium and water are a part of solution for and.

Release form

  • tablets on 10 pieces in bezjyacheykovy planimetric packagings, on 1, 2 or 10 packagings in a cardboard pack;
  • chewable tablets on 10 pieces in bezjyacheykovy planimetric packagings, on 1, 2 or 10 packagings in a cardboard pack;
  • solution for in/in and introductions in oil. Ampoules of 1, 2, 3, 5 and 10 ml, packaging No. 10.

Pharmacological action

Drug promotes recovery of deficit of calcium, renders antiallergic, haemo static, disintoxication, antiinflammatory action.

Takes part in transfer of nervous impulses, fibrillation, reduction of smooth and skeletal muscles and some other physiological processes.

Pharmacodynamics and pharmacokinetics

Calcium gluconate — what is it?

The gluconate of calcium is a mineral additive which is applied to treatment of the states provoked by deficit of Sa in an organism. Content of calcium in drug — 9%. MNN (Calcium gluconate) is appropriated to active agent on the basis of data of the European Pharmacopoeia (Ph.Eur.).

Ions of Ca participate in transfer of nervous impulses, without them the myocardium, reduction of smooth and skeletal muscles, blood coagulation processes cannot normally function; without them the bone tissue cannot normally form, and also other bodies and systems cannot function.

Gross - a calcium gluconate formula — C12H22CaO14.


At many diseases concentration of ions of Sa in blood decreases; at the same time the expressed deficit of calcium promotes development of a tetany. Drug not only interferes with emergence of a hypocalcemia, but also reduces permeability of vascular walls, stops an inflammation, has antiallergic and haemo static effect, reduces exudation.

Jonah S is a plastic material for teeth and a skeleton, with their participation many enzymatic processes proceed, they are responsible for regulation of permeability of membranes of cells and speed of transfer of nervous impulses.

They are necessary for process of a neuromuscular transmission and maintenance of sokratitelny function of a cardiac muscle. If to compare a calcium gluconate to calcium chloride, then the last has more expressed local irritative effect.


At intake substance is partially soaked up, mainly in a small bowel. TCmax — 1.2-1.3 hours. T1/2 of ionized Sa from a blood plasma — from 6,8 to 7,2 hours. Gets into breast milk and through a placental barrier. It is brought out of an organism generally by kidneys, but also and with intestines contents.

Indications to gluconate Calcium use

For what a calcium Gluconate in tablets?

Tablets are recommended at the states which are followed by a hypocalcemia, a hyperpermeability of cellular membranes, disturbances of carrying out nervous impulses in muscular tissue.

Doctors answer the question "what apply a calcium gluconate to?" that use of drug is reasonable at:

  • hypoparathyrosis (osteoporosis, latent tetany);
  • disturbances of an exchange of vitamin D (spasmophilia, rickets, osteomalacy);
  • hyperphosphatemias at patients with HPN;
  • the increased need for Sa (pregnancy, breastfeeding, the periods of intensive growth at children/teenagers);
  • the insufficient maintenance of Sa in a diet;
  • fractures of bones;
  • disturbances of an exchange of Sa in the post-menopausal period;
  • states which are followed by Sa strengthened removal (chronic diarrhea, a long bed rest; prolonged treatment by diuretics, GKS or antiepileptic drugs);
  • poisonings with oxalic acid, Mg salts, soluble salts of fluoric acid (expediency of use of means as an antidote is caused by the fact that, interacting with the specified substances, the gluconate of Sa forms non-toxic oxalate and fluoride of Sa).

As addition to the main treatment of a tablet of a gluconate of calcium are applied as allergy medicine at a pruritic dermatosis, a feverish syndrome, the small tortoiseshell, a serum disease, a Quincke's disease; at bleedings of various nature of an origin, nutritional dystrophy, bronchial asthma, a pulmonary tuberculosis, parenchymatous hepatitis, an eclampsia, nephrite, toxic damages of a liver.

For what calcium Gluconate pricks?

The calcium gluconate in ampoules is appointed at separate pathologies of epithelial bodies, states which are followed by the strengthened removal of Sa from an organism, as a supportive application from an allergy, and also at allergic complications of treatment other drugs, for decrease in permeability of vessels at different pathological processes, at nephrite, an eclampsia, intoxication of a liver, a hyperpotassemia, parenchymatous hepatitis, a giperkaliyemichesky form of periodic paralysis (a paroxysmal mioplegiya) as styptic means.

Indications (intravenously/intramusculary) for administration of drug are also poisonings with soluble salts of fluoric acid, oxalic acid or Mg salts, at skin diseases (psoriasis, an itch, eczema).

In some cases Calcium the gluconate is used when carrying out an autohemotherapy. Such method of treatment well proved at skin diseases, a furunculosis, recurrent colds, diabetes, rheumatism, allergy, during recovery after serious diseases.

To the patient enter 10 ml of solution of calcium of a gluconate into a vein, and then right there select blood from a vein and in the form of a subcutaneous injection or a prick transfer it to a gluteus back.

What is a hot prick?

Injections of drug are known also under the name "hot pricks of a gluconate of calcium". Actually, solution is entered warmed up only to body temperature.

We heat a prick call because of the subjective feelings arising at the patient: after an injection usually there is a feeling of heat spreading on a body, and sometimes and rather strong burning.

Calcium gluconate at an allergy

By physicians it is proved that the expressed deficit of Sa in an organism can be one of origins of an allergy. The majority of allergic reactions at children is connected with deficit of Sa: the children's organism very intensively grows as the result — decreases the maintenance of Sa in all its fabrics.

In addition, factors which promote formation of deficit of Sa are excess contents in an organism of vitamin D and a teething.

For this reason as one of ways of prevention and treatment of an allergy at the patients predisposed to this state the calcium gluconate quite often is used.

At sufficient intake of calcium in an organism permeability of vascular walls decreases decreases, and penetration of allergens into a system blood stream is at a loss. It means that increase of concentration of Sa is followed by decrease in probability of emergence of an acute immune response.

The gluconate of calcium is applied in a combination with antihistaminic drugs. Means is appointed including for elimination of side effects which reason reception of other drugs is.

The conducted researches prove that as a source only of Sa for an organism calcic salt of gluconic acid is the least active, however for treatment and prevention of any allergic diseases the gluconate of calcium is suitable best of all.

Pill is taken inside to food. The dose depends on features of a disease and age of the patient.

Besides, in some cases to the patient intravenous administration of solution can be appointed. The calcium gluconate at an allergy intramusculary or subcutaneously is not recommended to be entered (in particular to children).

The course of treatment from an allergy usually makes from 7 to 14 days.

The calcium gluconate at an allergy (responses are to it eloquent confirmation) is checked by time and rather effective remedy which, to crown it all, cannot almost be overdosed.

The maximum absorption of calcium is provided with the participation of vitamin D, amino acids (in particular, L-arginine and a lysine) and Sa-svyazyvayushchego of protein.


Contraindications to use of solution and tablets:

  • intolerance of components of drug;
  • the expressed hypercalcuria;
  • tendency to a thrombogenesis;
  • hypercoagulation;
  • the expressed atherosclerosis;
  • calcic nefrourolitiaz;
  • the increased coagulability of blood;
  • sarcoidosis;
  • severe form of a renal failure;
  • treatment period cardiac glycosides (for example, foxglove drugs).

Side effects

Drug is usually transferred well, but the following disturbances are in some cases possible:

  • bradycardia;
  • hypercalcuria, hypercalcemia;
  • nausea, vomiting, disturbances of a chair (locks/diarrhea), pain in epigastriums;
  • formation of calcic stones in intestines (at long reception of high doses of drug);
  • renal failures (hypostases of the lower extremities, the speeded-up urination);
  • hypersensitivity reactions.

At parenteral administration nausea, vomiting, bradycardia, diarrhea, feeling of heat in an oral cavity, and then and in all body, changes can sometimes be noted from skin. The specified reactions take place quickly enough and do not demand special treatment.

At fast administration of solution there can be nausea, the increased perspiration, vomiting, arterial hypotension, a collapse (in some situations — lethal). Calcification of soft tissues can become result of ekstravazalny hit of solution.

Allergic and anaphylactic reactions were seldom or never fixed.

At introduction of a gluconate of calcium intramusculary perhaps local irritation and necrosis of fabrics.

Application instruction of Calcium of a gluconate

Calcium tablets gluconate, application instruction

Pill is taken before food, previously having crushed or having chewed.

The single dose for patients is more senior than 14 years — from 1 to 3 g (2-6 tab. on each reception). Patients of 3-14 years are given on 2-4 tab. 2-3 rubles/days.

Treatment lasts from 10 days to 1 month. Duration of a course is defined by the attending physician individually depending on a condition of the patient.

Admissible upper limit of a daily dose for elderly patients — 4 tab. (2 g).

Calcium ampoules gluconate, application instruction

The gluconate intravenously or intramusculary is entered calcium.

To patients is more senior than 14 years of an injection do to 1 ruble/days. A single dose — from 5 to 10 ml of solution. Pricks depending on a condition of the patient are allowed to be done daily, every other day or once in two days.

For children from the birth till 14 years the dose of 10% solution of calcium of a gluconate in/in varies ranging from 0,1 to 5 ml.

Before introduction drug should be heated to body temperature. It is necessary to enter medicine slowly — within 2-3 minutes.

For introduction less than one milliliter of solution the single dose is recommended to be parted up to the necessary volume (syringe volume) with 5% solution of glucose or NaCl solution of 0,9%.


At prolonged treatment by high doses of a gluconate of calcium the risk of development of a hypercalcemia with adjournment of salts of Sa in an organism increases. The probability of a hypercalcemia increases at the simultaneous use of high doses of vitamin D or its derivatives.

The hypercalcemia is shown:

  • anorexia;
  • locks;
  • nausea/vomiting;
  • irritability;
  • increased fatigue;
  • polyuria;
  • abdominal pains;
  • polydipsia;
  • muscular weakness;
  • arterial hypertension;
  • arthralgia;
  • mental disorders;
  • nephrolithiasis;
  • nephrocalcinosis.

In hard cases the coma and cardiac arrhythmia are possible.

For elimination of symptoms of overdose it is necessary to cancel drug. In hard cases to the patient appoint intravenous administration of a calcitonin at the rate of 5-10 MO/kg/days. Means dissolve 0,9% of NaCl solution in 0,5 l and enter kapelno within six hours. Also slow drop introduction of an antidote of 2-4 rubles/days is allowed.



  • slows down absorption of an etidronat, estramustinum, biphosphonates, antibiotics of a tetracycline row, hinolon, drugs of fluorine and iron for intake (between their receptions it is necessary to maintain an interval not less than 3 hours).
  • reduces bioavailability of Phenytoinum;
  • increases cardiotoxicity of cardiac glycosides;
  • at patients with a hypercalcemia reduces efficiency of a calcitonin;
  • reduces effects of blockers of calcium channels;
  • increases toxicity of quinidine.

In a combination with quinidine provokes delay of intra ventricular conductivity, in a combination with thiazide diuretics the risk of development of a hypercalcemia increases. Vitamin D and its derivatives promote increase of absorption of Sa. Holestiramin reduces absorption of Sa in a gastrointestinal tract.

Forms insoluble or poorly soluble salts of Sa with salicylates, carbonates, sulfates.

Separate food stuffs (for example, a rhubarb, bran, spinach, cereals) are capable to reduce absorption of Sa from a digestive tract.

Are not compatible to solution:

  • carbonates;
  • sulfates;
  • salicylates;
  • alcohol.

Terms of sale

Tablets are means of non-prescription dispensing. The recipe is necessary for acquisition of ampoules with solution.

The recipe on Latin (sample): Rp.: Sol. Calcii gluconatis of 10% 10 ml D.t.d. 6 ampull. S. For intramuscular or intravenous administration (on 0,5-1 amp.).

Storage conditions

To store at a temperature below 25 °C. To protect from children.

Period of validity

Solution — 2 years. Tablets — 5 years.

Special instructions

Children till 14 flyings should enter a calcium gluconate because of a possibility of development of a necrosis exclusively intravenously.

Before filling of the syringe it is necessary to exclude existence of the alcohol remains in it (the deposit can be formed).

Treatment of patients with an urolithiasis in the anamnesis, reduced glomerular filtering or an insignificant hypercalcuria has to be carried out under control of the Ca2 level + in urine. To reduce risk of development of an urolithiasis it is recommended to use enough liquid.

"Faraonova of a dragon" from a calcium gluconate

Tablets of a gluconate of calcium are quite often used by chemists enthusiasts for receiving "a faraonovy snake" — a porous product which is formed of a small amount of the reacting substances.

The tablet is put on dry fuel, and then set fire to fuel. Light gray "snake" with spots of white color begins to creep out of a tablet. At the same time the volume of "a faraonovy snake" considerably exceeds the volume of initial substance: so, during some experiences from 1 tablet snakes length the 10-15th turned out.

During decomposition of a gluconate of calcium oxide of Sa, carbon dioxide, carbon and water are formed. The characteristic shade formed a dragon gives oxide of Sa. The only shortcoming of such "faraonovy snake" — her fragility, it is very easily scattered.


Coincidence on the ATH code of the 4th level:

Calcium glyukonat-Vial, Lekt, B. Brown; Additiva calcium, Hydroxyapatite, Glycerophosphate of a granule, Calcium lactate, Kalviv, Calcium pangamat, Kaltsy-Sandoz.


  • Calcium gluconate of 500 mg No. 30 of a tablet (renewal) PFK Updating of closed joint stock company
  • Calcium gluconate of 500 mg No. 20 of a tablet (renewal) PFK Updating of closed joint stock company
  • Calcium glyukonat-Vial 10% solution for injections of 10 ml No. 10 ampulyseverny Chinese Farm. Corporation of Ltd.
  • Calcium gluconate of 10% 10 ml No. 10 of amp. Moscow chemical pharmaceuticals to them N. A. Semashko of joint stock company
  • Calcium gluconate of 500 mg No. 10 tabletkiobnovleny PFK of closed joint stock company

Drugstore of IFC

  • Calcium gluconate Vial solution of 10% of amp of 10 ml No. 10, Vial of Ltd company / Northern Chinese Farm. Korpor. China
  • Calcium gluconate tbl 500 mg No. 30 **, Updating of CJSC Pfkrossiya
  • Calcium gluconate solution of 10% of amp of 10 ml No. 20, Braun Medicalgermaniya
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  • Calcium glyukonatgalichfarm (Ukraine, Lviv)
  • Calcium glyukonat10
  • Calcium a gluconate (stabilizing) solution for injections of 10% of an ampoule of 5 ml No. 10 Health (Ukraine, Kharkiv)
  • Calcium a gluconate solution of 10% 200 mlnauchno - experimental production of institute of an epizootology (At


  • Calcium gluconate of 500 mg No. 10 of the tab. Borisovsky ZMP (Belarus)
  • Calcium a gluconate of 10%/5 ml No. 10 solution for in.amp. Darnitsa (Ukraine)
  • Calcium glyukonat-N.S. 10%/5 ml No. 10 solution for in.amp. JSC Novosibkhimfarm (Russia)
  • Calcium a gluconate of 10%/5 ml No. 5 solution for in.amp.
  • Calcium a gluconate of 10% / 10мл No. 10 solution for in.amp. Farmak (Ukraine)
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Section: Gastrointestinal
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before Calcium medicine use a gluconate surely consult with the attending physician.