Ketilept

Кетилепт Drug photo

The description is actual on 29.05.2015

  • Latin name: Ketilept
  • ATH code: N05AH04
  • Active ingredient: Kvetiapin (Quetiapine)
  • Producer: EGIS PHARMACEUTICALS (Hungary)

Structure

150 mg, 100 mg, 25 mg, 200 mg, 300 mg of a kvetiapin can be a part of one tablet of medicine of Ketilept.

Additional substances: monohydrate of lactose, cellulose microcrystallic, sodium carboxystarch, magnesium stearate, povidone, silicon dioxide.

Structure of a cover: titanium dioxide, gipromelloz, macrogoal 4000, monohydrate of lactose, triacetin.

Release form

White biconvex tablets of a round form, with an engraving in the form of "E" and "202" on one surface, inodorous.

  • 10 tablets a dosage of 25 mg in the blister; three or six blisters in a pack from a cardboard.
  • 30 or 60 tablets a dosage of 25 mg in a dark, glass bottle; one bottle in a cardboard pack.
  • 10 tablets a dosage of 100 mg, 150 mg, 200 mg or 300 mg in the blister; six blisters in a cardboard pack.

Pharmacological action

Antipsychotic action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug relating to group of neuroleptics. Drug shows bigger affinity to receptors of serotonin of type 5-HT2, than to receptors of a dopamine of the D1 and D2 type. Also possesses the best affinity to α1-адренорецепторам and to histamine receptors, than to α2-адренорецепторам.

Kvetiapin causes not expressed katalepsy in the dose blocking D2 dopamine receptors in animals. Selectively suppresses mesolimbic dopaminergic neurons.

Does not cause long increase of level of prolactin. Efficiency of drug at treatment of symptoms of schizophrenia is proved.

Action on receptors of type 5-HT2 and D2 continues within 12 hours after the use of medicine.

Pharmacokinetics

When using inside it is well soaked up from intestines. Meal does not change bioavailability. Linkng with proteins of plasma reaches 83%.

It is actively transformed in a liver. CYP3A4 is the main enzymemetabolism of a kvetiapin. The main derivatives do not possess the expressed activity.

Time of semi-removal makes about 7 hours. About 72% of active agent are removed with urine and 22% through intestines. To 5% of a kvetiapin it is removed in an invariable form by kidneys or intestines.

Indications to use

  • Psychoses of acute and chronic character, including schizophrenia.
  • Therapy of maniacal episodes against bipolar disorder.
  • Therapy of depressive episodes against bipolar disorder.

Contraindications

With care use drug at persons with the convulsive attacks, a liver failure, cardiovascular and cerebrovascular frustration or other states provoking arterial hypotension; at elderly patients.

Side effects

  • Frustration from a hemopoiesis: eosinophilia, leukopenia, neutropenia.
  • Frustration from a metabolism: increase in weight, increase of content of the general cholesterol, serumal transaminases, GGT, triglycerides after the use of food, a diabetes mellitus, a hyperglycemia.
  • Frustration from a nervous system: headache, dizziness, alarm, drowsiness, psychomotor excitement, faints, tremor, epileptic seizures.
  • Frustration from blood circulation: orthostatic hypotension, tachycardia.
  • Frustration from breath: pharyngitis, rhinitis.
  • Frustration from digestion: a lock, dryness in a mouth, dyspepsia, diarrhea, an abdominal pain.
  • Frustration from the sexual sphere: priapism.
  • Allergic reactions: hypersensitivity.
  • Other reactions: subfebrile condition, easy adynamy, back pain and thorax, peripheral hypostases, xeroderma, mialgiya, visual acuity lowering, antipsychotic malignant syndrome.

Application instruction of Ketilept (Way and dosage)

The application instruction of Ketilept orders to take a pill inside, regardless of meal.

At psychoses of acute and chronic character, including schizophrenia, medicine appoint twice a day. The general day dose in the first four days of treatment is equal: 50 mg in the first day, 100 mg in the second day, 200 mg in the third day and 300 mg – in the fourth. From the fourth day the daily dose of means of Ketilept makes usually 300-450 mg. The daily dosage can vary within 150-750 mg. The greatest recommended daily dosage at this pathology is equal to 750 mg.

For therapy of maniacal episodes against bipolar disorder medicine is taken twice a day. The general day dose in the first four days of treatment is equal: 50 mg in the first day, 100 mg in the second day, 200 mg in the third day and 300 mg – in the fourth. By sixth day selection of a dosage to 800 mg a day with a step to 200 mg a day. The effective dosage is usually in limits 400-800 in day. The greatest daily dosage at this pathology is equal to 850 mg.

For therapy of depressive episodes against bipolar disorder medicine is appointed once a day to night. The general day dose in the first four days of treatment is equal: 50 mg in the first day, 100 mg in the second day, 200 mg in the third day and 300 mg – in the fourth. The recommended dosage makes about 300 mg a day. The greatest recommended daily dosage at this pathology is equal to 600 mg.

It is recommended to apply the lowest dose to maintenance of remission. Patients should be inspected periodically for the purpose of identification of requirement of a maintenance therapy.

Resuming of the suspended course of treatment at the persons which were earlier accepting Ketilept

When resuming treatment less than in seven days after drug withdrawal, it is authorized to continue reception in a dosage, the corresponding maintenance therapy.

When resuming treatment at persons who did not receive drug more than seven days it is necessary to implement again recommendations of initial selection of a dosage and to establish it on clinical reaction of the patient.

The recommended initial dose at elderly patients is equal to 25 mg a day, then it is necessary to raise a dosage on 25-50 mg a day to achievement of an acceptable dosage which is usually lower, than at younger patients.

Patients with insufficiency of work of kidneys and a liver are recommended to begin treatment with 25 mg a day, then every day the dosage is raised on 25-50 mg to identification of an effective dose for this patient.

Overdose

Overdose signs: drowsiness, tachycardia and lowering of blood pressure, coma.

Overdose treatment: there are no selective antidotes; symptomatic therapy, maintenance of work of lungs and heart, ensuring necessary oxygenation and ventilation.

Interaction

At combined use with Ketokonazol or Erythromycin increase of concentration of active agent of Ketilept in blood and development of undesirable effects is not excluded.

At simultaneous use with Carbamazepine, Phenytoinum, Rifampicin, barbiturates concentration of a kvetiapin in blood decreases.

At combined use with Thioridazine acceleration of removal of a kvetiapin is registered.

Terms of sale

According to the recipe.

Storage conditions

To store at the room temperature. To protect from children.

Period of validity

4 years.

Special instructions

Drug should be used with care at persons with the diagnosed diseases of bodies of blood circulation, cerebrovascular frustration or other states leading to arterial hypotonia.

Drug can provoke orthostatic hypotension, mainly in an initial stage of treatment and at elderly patients.

Ketilept at prolonged use it is capable to cause development of late dyskinesia. In a similar case it is necessary to resolve an issue of lowering of a dosage or cancellation of medicine.

Communication of an antipsychotic malignant syndrome with the carried-out antipsychotic therapy is not excluded. The syndrome is characterized by muscular rigidity, a hyperthermia, the changed cognitive status, lability of a vegetative nervous system, increase of level of a kreatinfostfokinaza. In similar cases of Ketilept it is necessary to cancel and carry out the corresponding therapy.

Signs of acute cancellation are very rare after the sudden termination of reception of high doses of means. However in case of need stops of administration of drug gradual lowering of a dose consults.

Drug is capable to cause orthostatic hypotonia with development of dizziness, tachycardia and faints, mainly in an initial stage of treatment.

In extremely exceptional cases during reception of means cases of a hyperglycemia and an exacerbation of the existing diabetes are noted.

Ketilept it is capable to cause drowsiness therefore in an initiation of treatment it is necessary to forbid the patient control of vehicles.

Analogs

Gedonin, Viktoel, Kventiaks, Kvetiteks, Ketiap, Lakvel, Kutipin, Nantarid, Serokvel, Servitel, Kvetiapin, Serokvel Prolong.

Zdravzona

  • Ketilept 300 mg No. 60 tabletkiegis
  • Ketilept 150 mg No. 60 tabletkiegis
  • Ketilept 200 mg No. 60 tabletkiegis
  • Ketilept 100 mg No. 60 tabletkiegis
  • Ketilept 100 mg No. 10 tabletkiegis

Drugstore of IFC

  • Ketilept tbl p/pl/o 100 mg No. 60 *, Egisvengriya
  • Ketilept tbl p/pl/o 200 mg No. 60 *, Egisvengriya
  • Ketilept tbl p/pl/o 300 mg No. 60 *, Egisvengriya
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Apteka24

  • Ketilept tablets coated 100 mg No. 30egis (Hungary/France)
  • Ketilept tablets coated 200 mg No. 30egis (Hungary/France)
  • Ketilept tablets coated 25 mg No. 30egis (Hungary/France)

Paniapteka

  • Ketilept tab. p / obol. 100 mg No. 30egis
  • Ketilept tab. p / obol. 100 mg No. 30egis
  • Ketilept tab. p / obol. 100 mg No. 30egis
Section: For a nervous system
in more detail

Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
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