Klenzit With

Клензит С Drug photo

The description is actual on 02.10.2014

  • Latin name: Klenzit-C
  • ATH code: D10AX30
  • Active ingredient: Adapalen + Clindamycin (Adapalene + Clindamycin)
  • Producer: Glenmark Pharmaceuticals Ltd. (India)


1 gram of gel contains 1 mg of Adapalen + 10 mg of Clindamycin – active agents.

Auxiliary ingredients:

  • propylene glycol;
  • dinatrium edetat;
  • methylparahydroxybenzoate;
  • carbomer 940 (karbopol 940);
  • phenoxyethanol;
  • sodium hydroxide;
  • half-oxameasures 407;
  • the water purified.

Release form

Klenzit With is issued in the form of gel for external use.

Packaging contains 1 tuba of 1 mg +10 mg / 1 of gel on 15 g or 30 g.

Pharmacological action

Antiinflammatory, komedonolitichesky, bacteriostatic.

Pharmacodynamics and pharmacokinetics

Gel of Klenzit With is the combined medicine for treatment of an acne (acne rash), topical administration. Act as active agents Adapalen and Clindamycin.

Derivative retinoid — Adapalen, shows antiinflammatory and komedonolitichesky activity. Has influence on the opened and closed comedones, contributes to normalization of processes of epidermal differentiation and keratinization. Drug reduces the moment of binding of follicular cells of an epithelium which promote formation of microcomedones, and also oppresses hemokinetichesky reactions and a chemotaxis of polynuclear cells.

Antimicrobic means Clindamycin belongs to group of linkozamid and possesses bacteriostatic activity in relation to many microorganisms. Clindamycin communicating with 50S in subunit of ribosomalny membranes, oppresses replication of protein in a bacterial cell. Also shows bactericidal action in relation to some gram-positive cocci.

At the therapy which is carried out using Klenzit With at patients with an acne illness lowering of intensity of an inflammation, reduction of acne elements, and also decrease in number of comedones and the general improvement of a condition of integuments of the person is noted.

Due to the external use of drug of Klenzit With its system absorption it is insignificant.

Indications to use

Treatment of an acne (acne illness).


With care apply at eczema and dermatitis.

Side effects

Treatment using gel of Klenzit With generally takes place without any serious complications. At some patients, seldom observed a hyperemia, irritations, peelings of integuments. In such cases recommend to suspend temporarily therapy and to continue treatment after disappearance of these side effects.

At the beginning of a course of treatment, the exacerbation of acne rash passing in further process of therapy can sometimes be noted.

Isolated cases development of allergic manifestations which serve as the indication for full cancellation of treatment are described.

Application instruction (Way and dosage)

Klenzit With in the form of gel it is intended for external (local) use.

How to apply gel, the application instruction recommends to clear and dry up problem sites of face skin. Drug is applied with dot smears, without rubbing and without using on skin sites with the damaged integrity and/or burns.

Recommend to apply gel before going to bed. When drawing in the afternoon days, follows for the next 1-2 hours, to refrain from imposing of a make-up and washing.

It is necessary to avoid hit of medicine in a nasal cavity, a mouth and mucous eyes.

Duration of carrying out a course of therapy and the scheme of use of drug of Klenzit With are determined by the attending physician. Depending on complexity of a course of a disease appoint 1 or 2 applications a day. Following the instruction to Klenzit With the average duration of therapy makes 14-28 days. Purpose of a repeated course of treatment, after consultation with the attending physician is possible.


Because gel of Klenzit With is applied exclusively outwardly, its overdose is improbable.

At accidental reception of gel inside recommend immediate carrying out a gastric lavage and reception of enterosorbentny means.


Along with Klenzit With it is not necessary to apply alcohol-containing means, and also ointments and creams with the drying, irritating effect.

Do not recommend the combined Klenzit C's use and the medicines containing calcium gluconate, aminoglycosides, Ampicillin, magnesium sulfate and a complex of vitamins B.

Perhaps joint appointment from Benzoyl peroxide.

Simultaneous use of Klenzit C with Erythromycin leads to mutual decrease in efficiency.

Terms of sale

According to the recipe.

Storage conditions

At a temperature not above 25 °C.

Period of validity

24 months.

Special instructions

At the beginning of passing of a course of therapy with use of gel of Klenzit About perhaps exacerbation of an acne illness which independently disappears in further process of treatment.

In case of manifestation of irritation of integuments it is necessary to stop putting gel (temporarily or absolutely).

It is necessary to avoid natural or artificial (sunbed) of ultraviolet radiation. In need of long stay on the sun putting gel needs to be carried out in 24 hours before.

Gel use, on the damaged integuments, is not allowed.

In case of hit of gel in an oral cavity or a nose, and also on mucous an eye, it is necessary to wash away carefully it warm water.


Coincidence on the ATH code of the 4th level:

Analogs of gel of Klenzit With are issued in dosage forms for topical administration and can represent: ointment, cream, gel or solution for external use. At impossibility, for any reasons, uses of gel of Klenzit With appoint its analogs:

Drugstore of IFC

  • Klenzit About gel 0,1% 15 g, Glenmarkindiya
  • Klenzit About gel 0,1% 30 g, Glenmarkindiya
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Section: Dermatological
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Education: Graduated from the Vinnytsia national medical university of N. I. Pirogov, pharmaceutical faculty, the higher pharmaceutical education – the specialty "Pharmacist".

Experience: Work in Koneks and Bios-Media pharmacy chains as "Druggist". Work as "Pharmacist" in Avicenna pharmacy chain of the city of Vinnytsia.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before use of medicine of Klenzit With surely consult with the attending physician.