Drug photo

The description is actual on 13.03.2016

  • Latin name: Clindamycin
  • ATH code: J01FF01
  • Active ingredient: Clindamycin (Clindamycin)
  • Producer: Hemofarm (Serbia), VERTEXUM (Russia)


Clindamycin is a part of capsules active component clindamycin (a hydrochloride form), also additional ingredients: talc, monohydrate of lactose, starch corn, magnesium stearate.

Solution contains active ingredient clindamycin (a phosphate form), also auxiliary ingredients: benzyl alcohol, dinatrium edetat, water.

Cream Clindamycin contains active ingredient in structure clindamycin (a phosphate form), also auxiliary ingredients: macrogoal 1500, castor oil, sodium benzoate, propylene glycol, emulsifier No. 1.

Release form

Means is made in the form of capsules, solution and vaginal cream.

Capsules from gelatin, have the violet body and a lid of red color. Inside powder which can have white or white-yellow color contains. Capsules are packed into blisters on 8 pieces, in a pack from a cardboard on 2 such blisters.

Solution which is entered intravenously or intramusculary, transparent, it can be colourless or slightly yellowish. Contains in ampoules on 2 ml. In blister strip packagings on 5 ampoules, in a cardboard pack 2 packagings.

Ointment of vaginal 2% can have white, yellow-white, cream shades. Possesses weak specific aroma. Contains in tubas from aluminum on 20 g or 40 g, the applicator is included in the package.

Pharmacological action

Substance clindamycin belongs to group of antibiotics-linkozamidov. Has a wide range of influence, is bakteriostatiky.

In an organism takes up with 50S in subunit of a ribosome and inhibits protein synthesis in microorganisms. Shows activity in relation to Staphylococcus spp., Streptococcus spp. (an exception Enterococcus spp is.), to Streptococcus pneumoniae, anaerobic and mikroaerofilny gram-positive cocci, Clostridium tetani, Clostridium perfringens, Corynebacterium diphtheriae, Mycoplasma spp., Bacteroides spp. (including Bacteroides melaningenicus and Bacteroides fragilis). Also shows activity in relation to anaerobic gram-positive, not forming dispute, to bacilli.

Also most part of strains of Clostridium perfringens, but other kinds of clostridiums are sensitive to this substance (in particular Clostridium tertium, Clostridium sporogenes) show stability to this drug. In this regard at the diseases provoked by Clostridium spp., it is recommended to antibiotikogramm to carry out before an initiation of treatment.

The mechanism of influence of this medicine and its antimicrobic range is close to lincomycin.

The clindamycin substance form phosphate is inactive in vitro, however it is quickly hydrolyzed by in vivo, and at the same time the clindamycin showing antibacterial activity is formed.

Pharmacokinetics and pharmacodynamics

Clindamycin is completely and quickly soaked up from a gastrointestinal tract, at a concomitant use of food absorption is slowed down, at the same time concentration of substance in plasma remains invariable. Gets into fabrics and liquids of an organism, badly passes through GEB, but in case of an inflammation of covers of a brain permeability increases.

The maximum concentration in blood is noted at intake later 0.75-1 h if intramuscular introduction, in 1 hour at adult patients and in 3 hours at children is carried out. At introduction intravenously the greatest concentration is observed to the end of infusion.

Therapeutic concentration in blood for 8-12 hours are noted. The elimination half-life is equal to 2,4 h. The metabolism occurs in a liver, at the same time active and inactive metabolites are formed. Removal passes for 4 days through kidneys and through intestines.

At introduction of means intravaginalno about 3% of the entered dose are exposed to system absorption.

Indications to use

Solution and the tablets Clindamycin apply at such diseases and states:

  • diseases of infectious and inflammatory character which were provoked by action of the microorganisms sensitive to clindamycin;
  • infections of ENT organs, and also infectious diseases of upper respiratory tracts and lower respiratory tracts;
  • diphtheria, scarlet fever;
  • urogenital infections;
  • infections of an oral cavity, abdominal cavity;
  • infections of soft tissues and integuments;
  • septicaemia (first of all, anaerobic);
  • osteomyelitis acute and chronic;
  • the endocarditis is bacterial;
  • reception for the purpose of prevention of abscesses intra belly and peritonitis after perforation of intestines or after traumatic infection (it is combined with aminoglycosides).

Cream and gel Clindamycin is applied at a bacterial vaginosis.

Indications to use of candles with clindamycin:

  • the bacterial vaginosis provoked by the microorganisms sensitive to substance.


Use of this means is contraindicated:

  • at bronchial asthma;
  • at a myasthenia;
  • at ulcer colitis;
  • at rare diseases of hereditary character (a lack of lactase, intolerance of a galactose, glyukozo-galaktozny malabsorption);
  • at pregnancy and chest feeding;
  • at the age of the child till 3 flyings introduction intravenously and intramusculary is contraindicated, aged till 8 flyings reception of capsules is contraindicated;
  • high sensitivity to medicine components.

Carefully appoint to people who have a renal or liver failure in a severe form, to patients of advanced age.

Side effects

At drug intake at patients some side effects can be observed:

  • system of digestion: dispepsichesky phenomena, jaundice, esophagitis, pseudomembranous coloenteritis, hyperbilirubinemia, dysbacteriosis, abnormal liver functions;
  • musculoskeletal system: in rare instances disturbance of neuromuscular conductivity can be observed;
  • hemopoiesis: leukopenia, neutropenia, agranulocytosis, thrombocytopenia;
  • displays of an allergy: rash, a skin itch, the small tortoiseshell, sometimes – dermatitis, anaphylactoid manifestations, an eosinophilia;
  • heart and vessels: at administration of solution intravenously and quickly – lowering of arterial pressure, weakness, dizziness;
  • local manifestations: morbidity and thrombophlebitis (in an injection site), irritation;
  • other by-effects: superinfection.

At cream use Clindamycin such collateral manifestations can develop:

  • urination: irritation mucous vaginas and vulvas, candidiasis vaginal, vulvovaginitis, mecotic vaginitis, vaginal infections, disturbances of a monthly cycle, bleeding uterine, colpodynia, dysuria, emergence of allocations, endometriosis, glucosuria, proteinuria;
  • general manifestations: pain and spasms in a stomach, abdominal distention, fungal and bacterial infections, a headache, an unpleasant smell from a mouth, hypostasis inflammatory, pain in the bottom of a stomach, upper respiratory tract infections, a dorsodynia, allergic manifestations;
  • gastrointestinal tract system: nausea, diarrhea, lock, vomiting, meteorism, dyspepsia, disorders of a gastrointestinal tract;
  • integuments: skin itch, erythema, rash, candidiasis, small tortoiseshell;
  • endocrine system: hyperthyroidism;
  • TsNS: dizziness;
  • respiratory system: bleeding from a nose.

Application instruction of Clindamycin (Way and dosage)

Clindamycin intravenously and intramusculary appoint in a dose 300 mg twice a day for adult patients. If treatment of a heavy infection is necessary, reception in days of 1.2-2.7 g of medicine is shown, this dose needs to be divided into 3-4 introductions.

It is impossible to appoint intramusculary a single dose of medicine which exceeds 600 mg. The greatest admissible dose for introduction intravenously – 1.2 g for 1 hour.

Children who were three years old have to receive a dose at the rate of 15-25 mg on 1 kg a day which needs to be divided into 3-4 times in equal doses.

In case of a heavy infection it is possible to increase a dose to 25-40 mg by 1 kg of weight, this dose needs to be divided into 3-4 identical introductions.

It is not necessary to adjust a dose to patients with a heavy renal or liver failure provided that drug is appointed with an interval by not less than 8 hours.

Before introduction it is intravenously necessary to part means to concentration no more than 6 mg/ml, the received solution is entered kapelno, the introduction period – from 10 to 60 minutes, depending on a dose. Struyno is not recommended to be entered. Solution of 0,9% of sodium chloride and solution of 5% of a dextrose can be solvent.

Tablets Clindamycin, application instruction

Pill needs to be taken orally, adult patients and teenagers after 15 flyings at moderately severe diseases receive on 1 kaps. 4 times a day. If the serious infectious disease takes place, the dose can be increased by 2-3 capsules. Children aged from 8 till 12 flyings appoint on 1 kaps. 4 times a day. It is impossible to exceed a dose 4 kaps. in days.

To teenagers from 12 to 15 years appoint on 1-2 kaps. 3 times a day. It is impossible to exceed a dose 6 kaps. in days.

The instruction on cream provides its intravaginalny use. It is the best of all to apply means before going to bed, for 3-7 days.

Candles with clindamycin are applied intravaginalno on 1 piece once a day.

Use candles before going to bed, a course – 3-7 days. Before use it is necessary to remove a protective film, to enter deeply into a vagina, it is necessary to do it in a prone position.


If there was an overdose of means, the negative effects described above can amplify. There is no specific antidote, in case of overdose the symptomatic treatment is carried out.

About cream overdose information is absent. At accidental hit of drug system effects which are shown after substance reception orally inside can develop.


Strengthening of effect of aminoglycosides of Streptomycin, Gentamycin, Rifampicin at a concomitant use with Clindamycin is noted.

Activates influence of competitive muscle relaxants, and also muscle relaxation which is caused by n-holinoblokatory.

It is not combined with barbiturates, Ampicillin, a calcium Gluconate, magnesium sulfate, Aminophyllinum.

The antagonism with Chloramphenicol and Erythromycin is noted.

It is not recommended to accept along with solutions which contain a complex of vitamins of group B, Phenytoinums, aminoglycosides.

It is impossible to appoint at the same time clindamycin and drugs with antidiarrheal action as the probability of development of pseudomembranous colitis increases.

At use along with opioid analgetics the effect of respiratory depression can amplify, up to development of an apnoea.

Cross resistance between Lincomycin and Clindamycin is observed. Also the antagonism between Erythromycin and Clindamycin is shown.

It is not recommended to apply with other drugs to introduction intravaginalno.

Terms of sale

It is possible to buy according to the recipe of the doctor.

Storage conditions

Solution and capsules need to be stored in the dark place, temperature at the same time has to make from 15 ° up to 25 °C. To protect from children.

Period of validity

Solution is stored 2 years, capsules – 3 years.

Special instructions

Display of pseudomembranous colitis both in the course of drug intake, and 2-3 weeks later after completion of therapy is possible. At such state at the person diarrhea, fever, a leukocytosis, abdominal pains is shown.

If such symptoms develop, it is necessary to cancel drug and to accept ion-exchange resins. At a severe form of colitis it is necessary to compensate the lost liquid, protein and electrolytes, to appoint intake of Vancomycinum or Metronidazole.

In the course of treatment it is impossible to take medicine which brakes an intestines peristaltics.

If long reception of means by children practices, it is necessary to control periodically a blood count and a condition of a liver of the patient. At reception of high doses of medicine it is necessary to control clindamycin in a blood plasma.

People for whom the severe form of a liver failure is diagnosed need to provide control of function of a liver.

Before administration of drug it is intravaginalno necessary to exclude laboratory Chlamydia trachomatis, Trichomonas vaginalis, Neisseria gonorrhoeae, Candida albicans, Herpes simplex which very often provoke development of a vulvovaginitis.

At clindamycin use there can intravaginalno be a strengthened development of insensitive microorganisms, in particular drozhzhepodobny mushrooms.

As there is a probability of insignificant system absorption of medicine, against use of candles or cream diarrhea can develop. In that case means is cancelled.

It is necessary to consider that during treatment it is necessary to abstain from sex life and not to use other drugs for use intravaginalno.

As a part of this medicine components which can make less strong products of rubber, latex contain. Therefore, it is not recommended to apply condoms, diaphragms and other contraceptives from latex.

Does not influence ability to steer the car or to be engaged in other types of activity which demand concentration of attention.

Analogs of Clindamycin

Coincidence on the ATH code of the 4th level:

Structural analogs on active ingredient are drugs Dalatsin, Zerkalin, Clindamycin phosphate, Klindatop, Klimitsin, Klindafer, Klindes, Klindatsin, Klindovit. The specialist has to appoint optimum means.


  • Clindamycin 150 of mg No. 16 kapsulykhemofarm A.D.
  • Clindamycin 150mgml solution for injections of 2 ml No. 10 ampulykhemofarm A.D.
  • Clindamycin of 2% cream vaginal 20gverteks closed joint stock company

Drugstore of IFC

  • Clindamycin kaps. 150 mg No. 16, Hemofarm koncern A.D.Serbiya
  • Clindamycin solution for infection amp of 300 mg 2 ml No. 10, Hemofarm koncern A.D.Serbiya
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  • Klindamitsin-M capsules 0.15g No. 10monfarm (Ukraine, Monastyrishche)


  • Klindamitsin-M capsules 0.15g No. 10


  • Clindamycin of 100 mg No. 3 supp.vag.farmaprim SRL (Moldova)
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Section: Antibiotics
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Education: "Pharmacy" graduated from the Rovno state basic medical college majoring in. Graduated from the Vinnytsia state medical university of M. I. Pirogov and internship on its base.

Experience: From 2003 to 2013 – worked at positions of the pharmacist and manager of a pharmaceutical booth. It is awarded by diplomas and distinctions for long-term and honest work. Articles on medical subject were published in local editions (newspaper) and on various Internet portals.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Clindamycin surely consult with the attending physician.