Clonidine

Клофелин Drug photo

The description is actual on 02.06.2015

  • Latin name: Clophelin
  • ATH code: C02AC01
  • Active ingredient: Clonidine
  • Producer: Organic chemistry (Russia), Dalkhimfarm (Russia), Moscow endocrine plant (Russia)

Structure

Active ingredient is the clonidine.

Tablets contain 0,075 mg or 0,15 mg of this substance. Auxiliary components are: magnesium stearate, potato starch, lactose.

1 ml of solution contains 0,1 mg of a clonidine.

1 ml of eye drops contains 1,25, 2,5 or 5 mg of active agent.

Release form

Is issued in the form of eye drops, tablets, solution for injections.

Pharmacological action

Clonidine is an antihypertensive. Pharmacological group: alpha adrenomimetiki.

Pharmacodynamics and pharmacokinetics

What is it — Clonidine? Active agent – a clonidine, is central alpha adrenomimetikom. The mechanism of influence is based on stimulation postsynaptic alpha 2 - the adrenoceptors located in a vasomotor center in a myelencephalon on decrease in a flow of sympathetic impulses at the presynaptic level to heart and vessels. Medicine reduces ChSS, reduces MOK, OPSS. Drug has the central effect. At fast intravenous injection the short-term lowering of blood pressure caused by stimulation of the postsynaptic alfa1-adrenoceptors located in walls of vessels is registered. Klofellin reduces a blood stream in a brain, raises a tone of brain vessels, increases a renal blood stream, makes the expressed sedative impact. Drug works within 6-12 hours. At a clonidine instillation in a conjunctival sac falling of intraocular pressure is noted. The effect is explained by stimulation of adrenoceptors at local contact that leads to decrease in production of intraocular liquid, improvement of its outflow, weakening of a sympathetic tone.

Indications to use

Clonidine — for what it is necessary? It is applied at hypertensive crisis, at an arterial hypertension (including at pathology of kidneys), at a pheochromocytoma (to diagnosis), at an acute myocardial infarction (at not diagnosing of symptoms of cardiogenic shock), at a dysmenorrhea, headaches of a vascular origin, at an abstinence syndrome at patients with a drug addiction (complex treatment), at a syndrome Gilles de la Turetta, at nicotine addiction. Eye drops Clonidine are applied at primary open angle glaucoma.

Contraindications

Clonidine is not applied to the expressed atherosclerosis form, at a depression, intolerance of a clonidine, an atrioventricular block 2-3 degrees, at cardiogenic shock, arterial hypotension, obliterating arterial diseases, at pregnancy, a concomitant use of ethanol, tricyclic antidepressants, chest feeding. At HPN and recently postponed heart attack medicine is applied with care.

Side effects of Clonidine

Digestive tract: loss of appetite, dryness in a mouth, decrease in secretion of a gastric juice, locks, vomiting, nausea.

Nervous system: "dreadful", bright dreams, depression, nervousness, uneasiness, delay of speed of motor and mental reactions, drowsiness, adynamy.

Cardiovascular system: short-term lowering of blood pressure at intravenous injection, orthostatic hypotension, bradycardia.

Side effects from urinogenital system: decrease in a libido, disturbance of a potentiality. Development of "gemitonovy crisis" at sharp drug withdrawal, puffiness of anklebones, Reynaud's syndrome is possible.

At local use of drops for eyes burning in eyes, dryness of a conjunctiva is noted. Most often occur among system reactions: bradycardia, locks, drowsiness.

Clonidine, application instruction (Way and dosage)

Pill is taken in independence of meal, inside. An initial dosage of 0,075 mg three times a day. In case of need the dosage is raised to 0,9 grams a day.

To patients of advanced age at the accompanying atherosclerosis appoint on 0,0375 three times a day.

Medicine is cancelled gradually for two weeks.

Dysmenorrhea: 14 days to periods, and also in the period of a cycle accept 0,025 mg twice a day.

At hypertensive crisis medicine is applied sublingual, intramusculary, intravenously by 0,15 mg. Before jet intravenous injection drug is dissolved in sodium chloride, entered 10 minutes.

According to the application instruction of Clonidine eye drops dig in 2-4 times a day in each conjunctival sac 1-2 drops. Therapy begin 0,25% of solution with use. At not achievement of required level of intraocular pressure apply 0,5% solution. At registration of the expressed side effects concentration of solution is reduced to 0,125%.

Overdose

It is shown by delay of atrioventricular conductivity, lowering of blood pressure, a collapse, respiratory depression, disturbance of consciousness, broadening of the QRS complex on an ECG, a syndrome of early repolarization, a hypothermia, a miosis, slackness. Therapy is carried out posindromny.

Symptoms of poisoning with substance: immersion in a deep sleep or a coma, oppressed consciousness, pressure and pulse very strongly fall, disorder of activity of mentality.

The lethal dose of Clonidine for the person makes 50-100 mkg on weight kg.

Interaction

Drug strengthens influence of medicines which oppress work of TsNS, ethanol. Anti-histamine means, diuretics, vazodilatator strengthen action of a clonidine, and anorexigenic means, tricyclic antidepressants, sympathomimetics, NPVS opposite, weaken efficiency. At purpose of cardiac glycosides, beta adrenoblockers the risk of development of an atrioventricular block, bradycardia increases. Clonidine it is not recommended to appoint eye drops with neuroleptics, antidepressants.

Terms of sale

The recipe is required.

Storage conditions

In the place, dry, dark, unavailable to children, at a temperature of 15-25 degrees Celsius.

Period of validity

No more than 4 years.

Special instructions

In today's medical practice Clonidine is practically not applied because of the expressed, sharp, short-term reduction of level of a blood pressure with the subsequent its increase, so-called "gemitonovy crises". Patients are not recommended to appoint drug at an abstinence syndrome with a drug addiction, at vasculomotor disturbances against a menopause and a dysmenorrhea, at an acute myocardial infarction. In such cases purpose of agonists of imidazolinovy receptors is more preferable. At prolonged use of medicine control of intraocular pressure is required. For the purpose of prevention of orthostatic hypotension at intravenous injections the patient has to be in horizontal position. During treatment registration of slabopolozhitelny reaction of Koombs is possible. Clonidine influences management of transport, attention. In the absence of effect of use of eye drops within 2 days medicine is cancelled. For the purpose of the prevention of development of system side effects after instillations it is recommended to press a finger a projection of a conjunctival sac for 1-2 minutes.

Clonidine in Wikipedia is described in the form of active ingredient the Clonidine.

The recipe of Clonidine on Latin:

Rp.: Clophelini 0,15 mg
    D. t. d. N 10 in tabul.
    S.

Clonidine with alcohol

Effects of use of Clonidine and alcohol together following: the person quickly gets drunk, coordination and feeling of in space is broken, the narcotic dream after which the person remembers nothing is caused, and there were even cases when people did not wake up after the use of such mix.

Even a small amount is not recommended to take alcoholic drinks with this substance. Effects can be catastrophic.

Coincidence on the ATH code of the 4th level:

Analogs are Haemitonum, Katapresan, Chlophazolinum.

Responses

Really effective medicine, however demands careful use and a dosage. Some consider drug outdated and specify that pressure after the use again sharply increases after a while.

The Clonidine price where to buy

Tablets of a medicine cost an average of about 30 rubles.

Where it is possible to buy Clonidine in drops? Medicine is sold in some Internet drugstores and drugstores of Moscow with delivery.

BIOSPHERE

  • Clonidine of 15 mkg No. 50 of table. Luhansk HFZ (Ukraine)
  • Clonidine of 15 mkg No. 30 of table. Health - the pharmaceutical company (Ukraine)
to show still
Section: Cardiovascular
in more detail

Education: Graduated from the Bashkir state medical university majoring in "Medical business". In 2011 gained the diploma and the certificate in Therapy. In 2012 received 2 certificate and the diploma in "Functional diagnosis" and "Cardiology". In 2013 completed courses on "Topical issues of otorhinolaryngology in therapy". In 2014 completed advanced training courses in "A clinical echocardiography" and courses in "Medical rehabilitation".

Experience: From 2011 to 2014 the Policlinic No. 33 Ufa worked as the therapist and the cardiologist in MBUZ. Since 2014 the Policlinic No. 33 Ufa works as the cardiologist and the doctor of functional diagnosis in MBUZ.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Clonidine surely consult with the attending physician.