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One tablet contains 0,5 or 2 mg of active ingredient clonazepam.
Is issued in the tableted form.
Anticonvulsant drug. Has calming, somnolent, myorelaxation, antiepileptic effects.
Pharmacodynamics and pharmacokinetics
The principle of action is based on stimulation of benzodiazepine receptors in reticular pharmacy. Thanks to influence on the amygdaloid complex located in limbic system anksiolitichesky influence is noted: uneasiness, concern, fear decreases.
Strengthening presynaptic braking, Clonazepam has anticonvulsant effect. Medicine positively influences focal, generalized forms of epilepsy.
Braking of afferent, spinal, polisinaptichesky brake ways causes the central myorelaxation effect.
Drug slows down activity of motor neurons.
Indications to use
Clonazepam is applied at atypical absentias epileptica, epilepsy, atonic attacks, nodding spasms, infantile spasms, toniko-clonic spasms. At intravenous administration medicine stops the epileptic status.
Drug is appointed at panic frustration, an alcoholic abstinence syndrome, psychomotor excitement, sleeplessness (at organic lesion of a brain), a muscle hyper tone, noctambulation.
Clonazepam is not applied at a severe form of HOBL, oppression of a respiratory center, shock, a coma, a myasthenia, acute respiratory insufficiency, a severe form of a depression, breastfeeding, pregnancy.
At hyperkinesias, a cerebellar ataxy, a spinal ataxy, an alcoholism, HSN, insufficiency renal/hepatic systems, psychoses, a bronkhospastichesky syndrome, organic diseases of a brain, a night apnoea, at elderly people appoint with care.
Nervous system: slackness, ataxy, katalepsy, block, feeling of fatigue, delay of a physical activity. The ecmnesia, memory impairment, a tremor, a depression, euphoria, headaches, depression of mood, a dysarthtia, a myasthenia, weakness, dystonic extrapyramidal reactions, paradoxical reactions is in rare instances noted.
Respiratory system: bronchial hypersecretion, oppression of a respiratory center.
Urinogenital system: dysmenorrhea, disturbance of a libido, pathology of renal system, incontience, urination delay.
Clonazepam causes accustoming, creates medicamentous dependence. Sharp drug withdrawal causes "withdrawal": agitation, the increased sweating, a tremor, a dysphoria, uneasiness, sleep disorders, irritability, a depression, a hyperacusia, a derealization, hallucinations, a hyperesthesia, a photophobia, paresthesias.
Clonazepam, application instruction (Way and dosage)
For children till ten years about 0,02 mg are appointed to kg a day. The therapeutic dose is calculated individually and there cannot be more, than 0,2 mg. 0,05-1 mg/kg a day. The maximum daily dosage for adults – 20 mg.
To children from 10 to 16 years appoint originally 1 mg for several receptions in days. Then the dose increases at most by 0,5 mg.
The adult appoint originally 1,5 mg for several receptions in days. Then the dose increases at most by 0,5 mg.
The application instruction of Clonazepam at a syndrome of paroxysmal fear
Initial dosage of 1 mg, maximum — 4 mg. Children till 16 flyings at this state are not recommended to use drug.
Elderly, and also to people with motive problems and renal failures the dose decreases.
Solution with clonazepam
For stopping of the epileptic status means is entered intravenously: to children of 0,5 mg, adult 1 mg kapelno, or slowly struyno. Amount of the drug administered intravenously should not exceed 13 mg. Solution for an injection is prepared just before introduction. Cancellation of medicine has to be carried out gradually.
Ataxy, dysarthtia, decrease in reflexes, paradoxical excitement, confusion of consciousness, drowsiness, coma, oppression of respiratory system, cardiac standstill. The hemodialysis does not bring effect, the gastric lavage is recommended.
Mutual strengthening of effects of muscle relaxants, narcotic analgetics, ethanol, general anesthetics, somnolent, antiepileptic HP, antidepressants, neuroleptics is noted.
At patients with Parkinson Klonazepam's illness weakens effect of the drug Levodopa.
Reception of narcotic analgetics increases risk of development of psychological dependence (cause euphoria).
Cimetidinum prolongs the period of effect of drug.
Terms of sale
The recipe is necessary.
In the place, dark, dry, unavailable to children, at a temperature no more than 25 degrees Celsius.
Period of validity
No more than three years.
For prevention of increase of epileptic seizures it is recommended to pass to other antiepileptic drugs gradually. During transition the probability of apathy, sedation amplifies.
During therapy alcoholic beverages are categorically contraindicated. Prolonged treatment demands control over a condition of blood.
Use of medicine during pregnancy causes forming of medicamentous dependence in a fruit, development of a syndrome of "cancellation" in the child after the delivery is possible.
Clonazepam exerts negative impact on performance of difficult work, control of mechanisms and transport.
Analogs of Clonazepam
Synonym: IC clonazepam.
Analog it is possible to call the medicine Rivotril.
Section: For a nervous system
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