Клоназепам Drug photo

The description is actual on 19.07.2015

  • Latin name: Clonazepam
  • ATH code: N03AE01
  • Active ingredient: Clonazepam


One tablet contains 0,5 or 2 mg of active ingredient clonazepam.

Release form

Is issued in the tableted form.

Pharmacological action

Anticonvulsant drug. Has calming, somnolent, myorelaxation, antiepileptic effects.

Pharmacodynamics and pharmacokinetics

The principle of action is based on stimulation of benzodiazepine receptors in reticular pharmacy. Thanks to influence on the amygdaloid complex located in limbic system anksiolitichesky influence is noted: uneasiness, concern, fear decreases.

Strengthening presynaptic braking, Clonazepam has anticonvulsant effect. Medicine positively influences focal, generalized forms of epilepsy.

Braking of afferent, spinal, polisinaptichesky brake ways causes the central myorelaxation effect.

Drug slows down activity of motor neurons.

Indications to use

Clonazepam is applied at atypical absentias epileptica, epilepsy, atonic attacks, nodding spasms, infantile spasms, toniko-clonic spasms. At intravenous administration medicine stops the epileptic status.

Drug is appointed at panic frustration, an alcoholic abstinence syndrome, psychomotor excitement, sleeplessness (at organic lesion of a brain), a muscle hyper tone, noctambulation.


Clonazepam is not applied at a severe form of HOBL, oppression of a respiratory center, shock, a coma, a myasthenia, acute respiratory insufficiency, a severe form of a depression, breastfeeding, pregnancy.

At hyperkinesias, a cerebellar ataxy, a spinal ataxy, an alcoholism, HSN, insufficiency renal/hepatic systems, psychoses, a bronkhospastichesky syndrome, organic diseases of a brain, a night apnoea, at elderly people appoint with care.

Side effects

Nervous system: slackness, ataxy, katalepsy, block, feeling of fatigue, delay of a physical activity. The ecmnesia, memory impairment, a tremor, a depression, euphoria, headaches, depression of mood, a dysarthtia, a myasthenia, weakness, dystonic extrapyramidal reactions, paradoxical reactions is in rare instances noted.

Respiratory system: bronchial hypersecretion, oppression of a respiratory center.

Alimentary system: heartburn, jaundice, increase of level of liver enzymes, disturbances of a chair, diarrhea, loss of appetite, dryness in a mouth.

Urinogenital system: dysmenorrhea, disturbance of a libido, pathology of renal system, incontience, urination delay.

Clonazepam causes accustoming, creates medicamentous dependence. Sharp drug withdrawal causes "withdrawal": agitation, the increased sweating, a tremor, a dysphoria, uneasiness, sleep disorders, irritability, a depression, a hyperacusia, a derealization, hallucinations, a hyperesthesia, a photophobia, paresthesias.

Clonazepam, application instruction (Way and dosage)

At epilepsy

For children till ten years about 0,02 mg are appointed to kg a day. The therapeutic dose is calculated individually and there cannot be more, than 0,2 mg. 0,05-1 mg/kg a day. The maximum daily dosage for adults – 20 mg.

To children from 10 to 16 years appoint originally 1 mg for several receptions in days. Then the dose increases at most by 0,5 mg.

The adult appoint originally 1,5 mg for several receptions in days. Then the dose increases at most by 0,5 mg.

The application instruction of Clonazepam at a syndrome of paroxysmal fear

Initial dosage of 1 mg, maximum — 4 mg. Children till 16 flyings at this state are not recommended to use drug.

Elderly, and also to people with motive problems and renal failures the dose decreases.

Solution with clonazepam

For stopping of the epileptic status means is entered intravenously: to children of 0,5 mg, adult 1 mg kapelno, or slowly struyno. Amount of the drug administered intravenously should not exceed 13 mg. Solution for an injection is prepared just before introduction. Cancellation of medicine has to be carried out gradually.


Ataxy, dysarthtia, decrease in reflexes, paradoxical excitement, confusion of consciousness, drowsiness, coma, oppression of respiratory system, cardiac standstill. The hemodialysis does not bring effect, the gastric lavage is recommended.


Mutual strengthening of effects of muscle relaxants, narcotic analgetics, ethanol, general anesthetics, somnolent, antiepileptic HP, antidepressants, neuroleptics is noted.

At patients with Parkinson Klonazepam's illness weakens effect of the drug Levodopa.

Carbamazepine, Phenytoinum, barbiturates, inductors of microsomal liver enzymes increase drug metabolism speed.

Reception of narcotic analgetics increases risk of development of psychological dependence (cause euphoria).

Cimetidinum prolongs the period of effect of drug.

Terms of sale

The recipe is necessary.

Storage conditions

In the place, dark, dry, unavailable to children, at a temperature no more than 25 degrees Celsius.

Period of validity

No more than three years.

Special instructions

For prevention of increase of epileptic seizures it is recommended to pass to other antiepileptic drugs gradually. During transition the probability of apathy, sedation amplifies.

During therapy alcoholic beverages are categorically contraindicated. Prolonged treatment demands control over a condition of blood.

Use of medicine during pregnancy causes forming of medicamentous dependence in a fruit, development of a syndrome of "cancellation" in the child after the delivery is possible.

Clonazepam exerts negative impact on performance of difficult work, control of mechanisms and transport.

MNN: Clonazepam.

Analogs of Clonazepam

Synonym: IC clonazepam.

Analog it is possible to call the medicine Rivotril.

Section: For a nervous system
in more detail

Education: Graduated from the Bashkir state medical university majoring in "Medical business". In 2011 gained the diploma and the certificate in Therapy. In 2012 received 2 certificate and the diploma in "Functional diagnosis" and "Cardiology". In 2013 completed courses on "Topical issues of otorhinolaryngology in therapy". In 2014 completed advanced training courses in "A clinical echocardiography" and courses in "Medical rehabilitation".

Experience: From 2011 to 2014 the Policlinic No. 33 Ufa worked as the therapist and the cardiologist in MBUZ. Since 2014 the Policlinic No. 33 Ufa works as the cardiologist and the doctor of functional diagnosis in MBUZ.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Clonazepam surely consult with the attending physician.