Кокарнит Drug photo

The description is actual on 14.04.2015

  • Latin name: Cocarnit
  • ATH code: A11DA
  • Active ingredient: Nikotinamid + cocarboxylase + cyanocobalamine + adenosine triphosphate
  • Producer: E.I.P.I.Co (Egypt)


In 1 ampoule of a nikotinamid of 20 mg, cocarboxylase of 50 mg, cyanocobalamine of 0,5 mg, adenosine of triphosphate of 10 mg.

Glycine, methylparahydroxybenzoate, propilparagidroksibenzoat — as excipients.

Release form

Lyophilisate for solution preparation + solvent lidocaine in ampoules.

Pharmacological action


Pharmacodynamics and pharmacokinetics


Represents a complex of the vitamins and substances influencing a metabolism. On the mechanism of action provides neurometabolic, analgetic effect and influences the emotional and vegetative sphere.

Nikotinamid favorably influences nitrogen and carbohydrate metabolism, participates in redoxreactions and promotes delivery of ATP in cells. Has sedative effect therefore it is effective at psychological frustration, alarm, a depression, decrease in attention.

Cocarboxylase — is the coenzyme playing a large role in carbohydrate metabolism, improves a trophicity of fabrics, influences synthesis of nucleic acids, proteins and lipids, promotes digestion of glucose.

Cyanocobalamine promotes synthesis and accumulation of protein, activates an exchange of fats and carbohydrates. Decrease in level of cholesterol and the prevention of a fatty hepatosis is result of this action. Cyanocobalamine increases regenerator ability of cells, is necessary for functioning of the hemopoietic bodies, a nervous system and a liver.

Adenosinetriphosphate — derivative adenosine, stimulates processes of a metabolism and is the main power substrate of a cell. At ischemia power deficit which decreases thanks to adenosinetriphosphate develops. Carries out its transportation in cells nikotinamid. Adenosinetriphosphate has antiarrhytmic, vasodilating and hypotensive effect.


It was not studied.

Indications to use

  • neuralgia of various origin;
  • neuritis;
  • lumbago, ischialgia, radiculitis;
  • neuropathy (for example, at a diabetes mellitus);
  • mialgiya, tendinites, bursitis;
  • Ischemic heart disease, myocardiopathy, myocarditis;
  • during pregnancy apply if the advantage for mother is more than risk for a fruit.


With care it is appointed at gastritis, a peptic ulcer, gout, damages of a liver. Data on use for children are absent.

In addition also contraindications for solvent — 0,5% of lidocaine of a hydrochloride have to be considered: a sick sinus syndrome, Adams-Stokes and Wolf-Parkinson-Whyte's syndrome, an angina of exertion, epileptiform spasms connected with lidocaine reception, a myasthenia, a porphyria, a heavy renal failure.

Side effects

To persons with hypersensitivity before administration of drug carry out an intracutaneous test.

Kokarnit's pricks, application instruction (Way and dosage)

About 1-2 ampoules daily are entered intramusculary. Kokarnit's pricks are carried out by courses which duration depends on disease severity.

Solution is used right after preparation, it has to be red color. If color did not change, it cannot be applied.

The instruction to Kokarnit contains the warning of need to carry out control of thrombocytes and erythrocytes, time of coagulation, bilirubin, uric acid and transaminases.


Kokarnit at accidental intake can cause manifestation of toxicity which is expressed by an itch, a dermahemia, a headache, nausea, heartburn, and vomiting.

Chronic intoxication is expressed by increase of level of glucose, uric acid, emergence of ulcers of a duodenum.


The cocarboxylase which is a part of drug strengthens cardiotonic effect of cardiac glycosides.

Nikotinamid exponentiates anticonvulsant effect of antiepileptic drugs (Diazepam, CarbamazepineValproatum).

Adenosinetriphosphate with kaliysberegayushchy diuretics, APF inhibitors and drugs of potassium increases risk of development of a hyperpotassemia. Strengthens anti-anginal effect of β-adrenoblockers and nitrates.

At reception with Dipiridamolum vasodilating action amplifies.

The antagonism at use together with caffeine and Theophylline is shown.

Ksantinol nikotinat reduces effect of adenosinetriphosphate, and Carbamazepine strengthens its action.

Aminoglycosides, potassium drugs, salicylates, antiepileptic drugs and Colchicine reduce cyanocobalamine absorption.

Cyanocobalamine absorption also decreases at reception of Kanamycinum, Neomatsina, Polymyxin, Tetracycline.

Cyanocobalamine is incompatible with ascorbic acid, the Pyridoxine, Riboflavinum, salts of heavy metals.

Oral contraceptives reduce concentration of cyanocobalamine in blood.

Terms of sale

According to the recipe.

Storage conditions

At a temperature from 15 to 25 °C.

Period of validity

3 years.

Kokarnit's analogs

Coincidence on the ATH code of the 4th level:

Structural analogs with identical active agent are absent.

About Kokarnita

Reviews of doctors of Kokarnit's pricks mostly testify to efficiency of drug in neurologic, neurosurgical and cardiac practice.

In scientific researches of the Belarusian scientists which applied Kokarnit in cardiac practice in the postoperative period conclusions are drawn that drug authentically reduces quantity wound separated, vertebrogenny pains, cases of use of non-steroidal anti-inflammatory drugs.

Researches showed that the condition of a myocardium when carrying out artificial circulation during operation was better at patients who accepted this drug in the presurgical period.

A number of researches was carried out at patients with myofascial dysfunction which appointed this drug. For the 10th day of treatment positive dynamics was observed: the pain and muscular and tonic syndrome decreased. The vegetative and emotional sphere of patients improved: the mood was normalized, there was an activity, uneasiness decreased.

Drug well proved in complex treatment of patients with discogenic lumbosacral radiculitis. Kokarnit about 2,0 ml a day from 14 to 21 days were applied intramusculary. The clinical effect came in 3 days. Regress of a pain itonichesky syndrome was noted for 3 - 5 days. Side effects at patients were not noted.


  • Kokarnit 0,187125 lyophilisate for solution for ampoule injections No. 3 + solvent 2 of ml No. 3 of an ampulye.i.p.a. To
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  • Kokarnit 2 ml No. 3 por.liof.d / solution for infection with r-leme.i.p.i.ko.proizvedeno for Uorld Meditsin, Great Britain (Egypt)
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Section: Vitamins For a nervous system
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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