Колпотрофин Drug photo

The description is actual on 26.07.2016

  • Latin name: Colpotrophine
  • ATH code: G03CA09
  • Active ingredient: Promestriyen (Promestriene)
  • Producer: Laboratories Theramex (Monaco); Teva Farmasyyutikalz (Netherlands)


In 1 vaginal capsule of a promestriyen of 10 mg. Sodium propilparagidroksibenzoat and methylparahydroxybenzoate, polyisobutene, soft paraffin, silicon oxide, dimetikon, sorbitan, gelatin, water as auxiliary components.

Release form

Soft vaginal capsules.

Cream vaginal 1% 15 g in a tuba.

Pharmacological action

Oestrogenic means for topical administration. Improves a trophicity mucous generative organs of the woman.

Pharmacodynamics and pharmacokinetics


Active ingredient renders local oestrogenic effect — recovers a vaginal epithelium and an epithelium of lower parts of an urogenital path, improves a trophicity and promotes its proliferation. Does not influence an endometria and a condition of mammary glands.


When using capsules or cream active agent is absorbed and less than 1% come to blood. In such concentration systemic estragene action is impossible.

Indications to use

Capsules and cream

  • the vaginal atrophy connected with deficit of estrogen (an itch and dryness of a vagina, an incontience of urine, a vaginita);
  • recovery mucous vaginas at inflammatory processes;
  • after operations on removal of ovaries;
  • healing of erosion of a neck of uterus after invasive methods of treatment;
  • before - and postoperative treatment (if intervention was carried out by intravaginalny access);
  • preparation of a neck for childbirth;
  • puerperal recovery mucous vaginas and necks of uterus.

The additional indication to cream use — synechias.


  • hypersensitivity;
  • estrogenzavisimy tumors (tumors of an endometria and breast cancer).

Side effects

Kolpotrofin, application instruction (Way and dosage)

All dosage forms of drug are applied intravaginalno. At urogenital frustration cream Kolpotrofin is applied on an urethra, a vulva and in a vagina entrance. The first week 1 time a day, the next 3 weeks — 1 time in 2 days is applied daily.

Terms of treatment are determined by the doctor. If there is a need the supporting treatment is carried out. In the plan before - and postoperative treatment cream is applied in a vagina of 1 times a day within 10-20 days. For the purpose of puerperal healing of a vulva and a crotch it is applied daily within 10 days. At synechias — 1 time days it is long before their full discrepancy.

Soft capsules (sometimes call candles Kolpotrofin) are entered into a vagina previously moistened 1 time a day. At urogenital frustration — till 20 days. At neck erosion — 10 days. By preoperative preparation — 10-20 days, for preparation for childbirth — in 5-6 days prior to childbirth. For the purpose of healing mucous after the delivery — 10 days.


Overdose is shown by strengthening of side reactions.


Promestriyen inactivates spermicidal means. The lubricants and oils which are contained in drug reduce durability of a latex condom and the risk of its gap appears.

Terms of sale

According to the recipe.

Storage conditions

Capsules — to 230 C.

Cream — to 140 C.

Period of validity

5 years.

Kolpotrofin's analogs

Coincidence on the ATH code of the 4th level:

Divigel, Ovestin, Estriol, Estrokad, Angélique (tablets), Femoston (tablets), Proginova (dragee).

About Kolpotrofin

The natural menopause or surgical climax are characterized by an estrogendefitsitny state. At 90% of women insufficiency of estrogen affects a physical state, causing an itch, dryness, cracks mucous external genitals, pain in an urethra, an urodynia and an incontience of urine. All these states are well stopped by local hormonal therapy.

As the cream, candles and vaginal capsules containing promestriyen (this case), estriol oestradiol or Norethisteronum have no systemic action, it is possible to apply them a long time. In certain cases doctors recommend to apply them constantly, time in 3 weeks.

  • "… I have a postoperative menopause and periodically there is an urethritis and cystitis. Cream excellent! Kills pains, gripes and other unpleasant symptoms. It is a pity that was gone from drugstores. Though the road, but periodically used it".
  • "… I used this cream after the delivery for healing of a crotch (did a section) and vaginas. Smeared 10 days for the night, so more conveniently. In ten days everything was normal".
  • "… Appointed to the daughter in 2 years — there were synechias of vulvar lips. Everything passed".

As for use of this drug before childbirth for the purpose of a softening of a neck of uterus, responses mostly negative — much it did not help and did not cause a sufficient softening. After the delivery to healing of the mucous woman more often it is not applied as for this time it is necessary to refuse feeding by a breast.

Section: Gynecologic Hormonal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Kolpotrofin surely consult with the attending physician.