Box Concor

Конкор Кор Drug photo

The description is actual on 06.11.2014

  • Latin name: Concor Cor
  • ATH code: C07AB07
  • Active ingredient: Bisoprolol (Bisoprolol)
  • Producer: MERCK, KGaA (Germany)


The structure of one tablet Box Concor includes gemifumarat and fumarates a bisoprolol in a quantitative ratio 2:1.
Excipients: silicon dioxide colloid, corn starch, MKTs, krospovidon, magnesium stearate, calcium hydrophosphate.
Structure of a cover: macrogoal 400, gipromelloza, dimetikon 100, titanium oxide.

Release form

Box Concor – the tablets covered with a white cover biconvex, a heart-shaped form, with a notch since both ends.

The existing release forms: 10 tablets in the blister, 3 blisters in a paper pack; 14 or 30 tablets in the blister, 1 blister in a paper pack; 25 tablets in the blister, 1 blister in a paper pack.

Pharmacological action

Has hypotensive, antiarrhythmic, anti-anginal effect.

Pharmacodynamics and pharmacokinetics


Bisoprolol – the selective beta adrenoblocker which does not have sympathomimetic activity and membranostabiliziruyushchy action.

Lowers: the maintenance of a renin in blood, need of heart for oxygen, number of cordial reductions. Blocks in small doses β1-адренорецепторы, reduces activation by catecholamines of synthesis of tsAMF from ATP, lowers intracellular transit of calcium ions, conductivity and excitability oppresses, brakes AV conductivity. At increase of a dose renders β2-адреноблокирующий effect.

The general peripheric resistance in the first days increases a little, and in 1-3 days comes to initial value, and at long-term appointment decreases.

Pressure decline is caused by sympathetic action on peripheral vessels, reduction of minute blood volume, work braking a renin-angiotenzinovoy of system. At an arterial hypertension the effect appears in 2-5 days.

Anti-anginal action is caused by reduction of need of heart for oxygen as a result of decrease in number of cordial reductions for a unit of time and contractilities, lengthenings of a diastole.

Antiarrhytmic action is connected with elimination of tachycardia, arterial hypertension, the increased activity of sympathetic system, the increased maintenance of tsAMF, AV conductivity braking.


Bioavailability – 85-90%; meal does not influence it. Bisoprolol is adsorbed from intestines for 90%. The maximum content in blood comes in 3 hours. Linkng with blood proteins – to 35%.

Undergoes transformations on an oxidizing way. The main derivatives are pharmacological not active. It is removed by kidneys.

Indications to use Box Concor

Indications to use of drug are rather limited. Persons of the senior age category often long heart failure for chronic type from what the tablets Box Concor are appointed at therapy of this pathology.


  • Hypersensitivity to a bisoprolol or other components of drug.
  • AV blockade.
  • Acute and chronic (decompensation) heart failure.
  • Hypotension is arterial.
  • Syndrome of weakness of a sinus node.
  • Bradycardia.
  • Sinuatrial blockade.
  • Bronchial asthma or HOBL.
  • Cardiogenic shock.
  • Disturbances of an arterial link of peripheric circulation.
  • Pheochromocytoma.
  • Age till 18 flyings.
  • Metabolic acidosis.

Side effects

    • General disturbances: adynamy, fatigue.
    • From a nervous system: syncopal states, dizziness.
    • Mental disturbances: depression, hallucinations, sleeplessness.
    • From sight sense organs: conjunctivitis, hearing disorder.
    • From the blood circulatory system: pressure decline, AV conductivity disturbance, pulse urezheniye, orthostatic hypotension.
    • From respiratory system: bronchospasm, allergic rhinitis.
    • From the muscular device: spasms.
    • From system of digestion: vomiting, nausea, diarrhea, hepatitis.
    • From reproductive system: deterioration in a potentiality.
    • From skin: itch, rash, reddening, alopecia.
    • Laboratory indicators: increases in content of triglycerides, nuclear heating plant and ALT


Application instruction Box Concor (Way and dosage)

The instruction on medicine recommends to take a pill in the morning, orally, washing down with water. Not to chew, not to crush.

Therapy of chronic type of heart failure means Concor of Box demands carrying out titration and constant medical control. At titration the dose can be raised only when the previous dose is transferred well.

The maximum dose at therapy of heart failure on chronic type – bisoprolol in number of 10 mg of times a day.

In an initiation of treatment at reception of a half of the tablet Box Concor of the patient it is necessary to observe the first 4 hours, exercising control of pulse, pressure, conductivity indicators.


Symptoms: bronchospasm, AV blockade, bradycardia, hypoglycemia, excessive pressure decrease, acute heart failure.
Overdose therapy: termination of administration of drug and symptomatic therapy.


Yodosoderzhashchy X-ray contrast means and allergens for an immunotherapy increase risk of emergence of system allergic reactions in the persons receiving bisoprolol.

Phenytoinum, means for inhalation anesthesia increase cardiodepressive and hypotensive action of a bisoprolol.

Non-steroidal anti-inflammatory drugs, glucocorticosteroids and estrogen suppress hypotensive effect of the medicine Box Concor.

Cardiac glycosides, guanfatsin, verapamil, Reserpinum, Methyldopum, diltiazem and antiarrhytmic means increase risk of emergence of AV blockade, bradycardia and a cardiac standstill.

Nifedipine, diuretics, sympatholytics, clonidine, gidralazin lead to strong pressure decrease.

Tetracyclic and tricyclic antidepressants, neuroleptics, ethanol, sedatives can strengthen oppression of a nervous system.

Ergotamine increases risk of emergence of disturbances of a peripheral blood-groove.

Terms of sale

The recipe is necessary for acquisition of drug.

Storage conditions

  • At a temperature less than 25 °C.
  • To protect from children.

Period of validity

Three years.

Special instructions

Drug does not change ability to steer the car.

Analogs Box Concor

The most widespread analogs Box Concor: Bikard, Bisoprolol KRKA, Bisoprolol-Richter, Bisoprofar, Dorez, Concor, Koronal and others.


  • Box Concor 2,5mg No. 30 tabletkimerck KGaA

Drugstore of IFC

  • Box Concor tbl p / about 2,5mg No. 30, Merckgermaniya
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  • Concor of box of a tablet 2.5mg No. 30nikomed (Austria)


  • Concor of Box of 2,5 mg No. 30 tabl.p.o.merck KGaA (Germany)
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Section: Cardiological Cardiovascular
in more detail

Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Box Concor surely consult with the attending physician.