Creatinine is called the end product of a metabolism of the kreateninfosfat which is formed as a result of a metabolism in muscles. Characteristic feature of this substance is that it is not exposed to a reabsorbation, and is removed through kidneys by filtering in renal balls. For the diagnostic purposes the level of creatinine is defined both in urine, and in blood.

Definition of this indicator is included into biochemical analysis of blood.

Norm of creatinine

The norm of creatinine in blood for women makes 53-97 µmol/litre and 71-115 for men.

At children the level of this substance varies: for the first birthdays it makes from 53 to 106 µmol/litre, further there comes its gradual decrease to achievement of year: 18-35, and after gradual growth up to adult indicators is again observed.

The norm of creatinine in urine can will change depending on body weight, but as a rule, it remains in borders between 124 and 230 µmol/kg of body weight at men and a little less at women – 97-177 at women per day.

Analysis purpose

Level of creatinine is defined for:

  • Estimates of synthesis of the protein which is especially increased;
  • Estimates of filtrational ability of kidneys during morbid conditions;
  • Monitoring of a state of health of kidneys at effect of nefrotropny substances, at various diseases of kidneys;
  • Monitoring of function and metabolism of kidneys before the performed operations;
  • Control of complications, work-related kidneys during urogenital diseases, development of tumors, pregnancy.

Increase and lowering of the level of creatinine

Increase of level of this substance in blood can be observed at the following pathological diseases and states:

  • Hyperthyroidism;
  • Giantism and acromegalia;
  • Disturbances of work of kidneys of any etiology;
  • Reception of nefrotoksichny drugs, ibuprofen, fructose, glucose, lidocaine, acetone, ascorbic acid, etc.;
  • Raised to the prima of meat in food.

Increase of creatinine in can arise at:

  • Diabetes mellitus;
  • Excessive exercise stress;
  • Primary hypogonadism;
  • Giantism and acromegalia;
  • Various infectious diseases.

Reduction of creatinine in blood results:

  • Body degrowth;
  • During two last trimesters of pregnancy.

Decrease in creatinine in urine is caused by the following disturbances:

  • Paralysis;
  • Anemia;
  • Leukosis;
  • Chronic diseases of kidneys;
  • Acute dermatomioit;
  • Muscular atrophy.
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