Купренил Drug photo

The description is actual on 13.07.2016

  • Latin name: Cuprenyl
  • ATH code: M01CC01
  • Active ingredient: Penicillaminum
  • Producer: Teva (Israel)


1 tablet contains 250 mg of active agent Penicillaminum.

Act as additional components: magnesium stearate, monohydrate of lactose, talc, starch, povidone.

Release form

Cuprenil is issued in the tableted dosage form.

Pharmacological action

Anti-inflammatory drug.

Pharmacodynamics and pharmacokinetics

Active component – Penicillaminum. Cuprenil is complexing connection which makes immunodepressive and disintoxication impacts. With ions of iron, zinc, cobalt, gold, calcium, copper, mercury forms chelate complexes.

Medicine is capable to oppress several enzymes which take part in a sulphhydryl and disulfide exchange.

Interaction with cysteine leads to education a disulfide Penicillaminum cysteine of which big solubility in comparison with cysteine is characteristic (at a tsisteinuriya decrease in formation of cysteic stones in renal system is noted).

Medicine influences various links of immune system, suppresses production of enzymes from lysosomes, promotes braking of a chemotaxis of neutrophils, suppresses helper activity of T lymphocytes.

Cuprenil splits bonds between synthesizable molecules of tropocollagen that causes collagen synthesizing process disturbance.

Under the influence of Penicillaminum the level of a rhematoid factor decreases, concentration of pathological macroglobulins decreases.

Efficiency of medicine at a hepatolenticular degeneration is provided with the strengthened removal of ions of copper with urine, normalization of its content in fabrics.

Indications to use

Cuprenil is appointed at poisoning with copper, a hemosiderosis, Wilson-Konovalov's illness, a scleroderma, a tsistinovy nefrourolitiaz, poisoning with inorganic compounds, at fibroplastic option of a glomerulonephritis, alcoholic cirrhosis (the accompanying hepatomegalia), at a cystinosis, a cystinuria, chronic hepatitis, a pseudorheumatism.


  • Sensitivity to means components.
  • To pregnant women and in the period of a lactation.
  • System lupus erythematosus.
  • Aplastic anemia and agranulocytosis.
  • At rhematoid inflammatory process in joints together with dysfunction of kidneys.
  • Renal failure.
  • The use of the medicines causing side effects from kidneys and the hemopoietic system.
  • Thrombocytopenia.

Side effects

Urinary system: hamaturia, nephrotic syndrome, nephrite.

Nervous system: gravis myasthenia, a peripheral neuropathy, the polyneuritis caused by a lack of a pyridoxine, disturbance of flavoring perception.

Musculoskeletal system: polymiositis, arthralgia, dermatomyositis.

Alimentary system: intra hepatic cholestasia, glossitis, aphthous stomatitis, pancreatitis, nausea, vomiting, appetite disturbance, diarrhea.

Respiratory system: Gudpascher's syndrome, diffusion fibroziruyushchy alveolitis, intersticial pneumonitis.

System of a hemostasis, bodies of a hemopoiesis: agranulocytosis, aplastic anemia, leukopenia, eosinophilia, hemolitic anemia.

Development of erythematic rash, fever, alopecia, increase in mammary glands with forming of a galactorrhoea in women, mialgiya, volchanochnopdobny syndrome, allergic alveolitis, epidermal necrolysis of toxic genesis, skin rash is possible.

Cuprenil, application instruction (Way and dosage)

Cuprenil is accepted on an empty stomach inside.

Wilson-Konovalov's illness: an initial dosage of 250 mg, gradual increase in amount of drug to 0,75-1,5 grams a day. The dosage of a medicine is considered effective at daily removal of ions of copper at an urination more than 2 mg after a week of therapy. Further dose adjustment is made depending on the level of free ions of copper in blood.

Cystinuria: an average dose 2 grams a day in 4 receptions. Therapy demands plentiful reception of liquid, especially before going to bed. The first 4 weeks at chronic hepatitis, a pseudorheumatism, a scleroderma Cuprenil accept 125-250 mg in a dose. At registration of good tolerance the dose is increased by each 1-2 months by 125 mg. The therapeutic effect is registered not earlier than 3 months of treatment. If efficiency is not noted in 3 weeks, then the dose is gradually raised by each 1-2 months on 125 mg. In the absence of positive dynamics in 6 months Cuprenil is cancelled. At achievement of required effect drug accept a long time in the same dosage.


Side effects, allergic reactions are possible. Treatment on symptoms.


Chelate complexes are formed at at the same time use of iron preparations, gold.

Phenylbutazone, Levamisole, antimalarial means increase probability of strengthening of expressiveness of side effects.

Cuprenil is incompatible with antibiotics.

The Gematotoksichnost of a medicine increases at use of myelotoxic means.

Terms of sale

The recipe is required.

Storage conditions

In the place, unavailable to children, at a temperature no more than 25 degrees Celsius.

Period of validity

No more than three years.

Special instructions

Regular control over a condition of blood is carried out to the first half a year of therapy, the analysis of urine is carried out, to blood there are each 2 weeks. In 6 months drug is appointed monthly.

Each half a year control functionality of hepatic and renal systems.

At a cystinuria, Wilson-Konovalov's illness it is long appoint a pyridoxine (demands regular control over a condition of an urinary system, ultrasonography of kidneys).

At development of volchanochnopodobny reactions, neurologic symptomatology, a myasthenia, defeat of pulmonary fabric, fervescence, a hamaturia, hematologic symptomatology Cuprenil is cancelled and appoint glucocorticosteroids.

At registration of the isolated proteinuria therapy is continued at not exceeding of an indicator of 1 g a day (in other situations drug is cancelled).

Analogs of Cuprenil

Analogs it is possible to call drugs: Artaminum, Bianodin, Penicillaminum.


  • Cuprenil 250 of mg No. 100 tabletkiteva Pharmaceutical
to show still


  • Kuprenilkutnovsky Federal Law "Polfa" (Poland)
Section: For a liver For joints Urological
in more detail

Education: Graduated from the Bashkir state medical university majoring in "Medical business". In 2011 gained the diploma and the certificate in Therapy. In 2012 received 2 certificate and the diploma in "Functional diagnosis" and "Cardiology". In 2013 completed courses on "Topical issues of otorhinolaryngology in therapy". In 2014 completed advanced training courses in "A clinical echocardiography" and courses in "Medical rehabilitation".

Experience: From 2011 to 2014 the Policlinic No. 33 Ufa worked as the therapist and the cardiologist in MBUZ. Since 2014 the Policlinic No. 33 Ufa works as the cardiologist and the doctor of functional diagnosis in MBUZ.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Cuprenil surely consult with the attending physician.