Ламизил Drug photo

The description is actual on 28.10.2015

  • Latin name: Lamisil
  • ATH code: D01AE15
  • Active ingredient: Terbinafin (Terbinafine)
  • Producer: Novartis Consumer Health (Switzerland)


As a part of tablets Lamizil contains active component terbinafin (in the form of a hydrochloride), and also additional components: silicon dioxide colloid anhydrous, magnesium stearate, starch sodium glycollate, MKTs, methylhydroxypropyl cellulose.

Spray Lamizil contains as a part of a terbinafin a hydrochloride as active component, and also additional components: 96% ethanol, macrogoal tsetostearat, propylene glycol, water.

Active component of a terbinafin a hydrochloride, and also additional substances is a part of ointment: sodium hydroxide, benzyl alcohol, sorbitan stearate, stearyl alcohol, palmitate of a tsetil, cetyl alcohol, isopropyl myristate, polysorbate 60, water.

Release form

Several forms of this medicine are made.

Tablets Lamizil can have white or white-yellow color, they biconvex, round, with risky, with a facet. Around tablets – a text "LAMISIL 250 ". Tablet surface rough. Contain in blisters on 7 or 14 pieces, blisters are put in cardboard packs.

Spray Lamizil is the colourless transparent liquid (can have a light yellow shade) having a characteristic smell. Contains in the bottles from polyethylene equipped with the sprayer tip on 15 and 30 ml. The bottle is put in cardboard packs.

Ointment Lamizil – homogeneous, white color, has a slight characteristic smell. Contains in aluminum tubas from aluminum on 15 and 30 g. Tubas are put in cardboard packs.

Pharmacological action

Lamizil – antifungal means.

Terbinafin is the allylamine having a broad spectrum of activity concerning mushrooms. Affects mushrooms which cause diseases of hair, nails, integuments. These are Trichophyton mushrooms (for example, Trichophyton tonsurans, Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton violaceum, Trichophyton verrucosum), Epidermophyton floccosum, Microsporum (Microsporum canis), barmy mushrooms of Candida (Candida albicans) and Pityrosporum.

At use of low concentration terbinafin has fungicidal effect concerning dermatophytes, mold mushrooms and a number of dimorphous mushrooms. Rather barmy mushrooms shows fungicidal or fungistatic activity.

Under the influence of a terbinafin biosynthesis of sterols in a cell at the earliest stage specifically is suppressed. As a result the lack of ergosterol and accumulation in squalene cells is noted owing to what cells of a mushroom perish. Influence of a terbinafin happens by skvalenepoksidaza enzyme inhibition in a membrane of cells of a mushroom.

If Lamizil is appointed inside, then in integuments, in nails and hair those concentration of drug which provide fungicidal effect collect.

At external use drug also shows a wide range of antifungal activity.

Terbinafin does not influence system of P450 cytochrome therefore it has no effect on process metabolismhormonesof and other drugs.

Pharmacokinetics and pharmacodynamics

After Lamizil in tablets was accepted inside, terbinafin is absorbed well, the level of absolute bioavailability of a terbinafin owing to effect of "the first passing" is equal about 50%. After drug was accepted in a dose of 250 mg orally, the maximum level of concentration in plasma is noted 1.5 hours later.

The maximum concentration increases if to accept drug regularly.

Meal influences bioavailability of active agent slightly, therefore, it is not necessary to adjust a medicine dose at reception along with food.

terbinafin contacts proteins of plasma for 99%. Fast penetration through a thermal layer of skin, concentration in a lipophilic corneous layer is noted it. Also its high concentration in hair, hair follicles, in integuments with a large number of sebaceous glands are noted. In nail plates availability of active component of drug in the first weeks after an initiation of treatment is defined.

It is quickly metabolized, owing to biotransformation of a terbinafin there is a formation of metabolites which do not show antifungal activity, are removed generally through kidneys.

If cream Lamizil or spray are applied outwardly, absorption of a terbinafin is equal less than 5%. Insignificant system influence is noted.

Indications to use

It is reasonable to take a pill Lamizil in the following cases:

  • at an onychomycosis which arises owing to influence of mushrooms of dermatophytes;
  • at mycoses of pilar part of the head;
  • at fungal infections of integuments – treatment of a fungus of foot, dermatomycoses of shins, trunks, and also for treatment of the infections provoked by sort Candida mushrooms.

It is necessary to consider that Lamizil for oral administration is not an effective remedy at multi-colored herpes.

It is reasonable to use cream and spray Lamizil in the following cases:

  • for the purpose of prevention of mycoses of feet, fungal infections of smooth skin, an inguinal epidermophitia which were provoked by dermatophytes;
  • for treatment of the intertrigo provoked by mold mushrooms;
  • for treatment multi-colored depriving, provoked by dimorphous mushrooms.


Means is not appointed to people who suffer from hypersensitivity to medicine components. It is not necessary to carry out treatment by Lamizil for a fungus of nails and for other diseases if the patient has liver diseases as chronic, and in an acute form. Therefore before an initiation of treatment it is necessary to define surely whether the patient has such diseases.

It is also necessary to consider that emergence of a gepatoksichnost both at people with liver diseases, and at those who had no such diseases is possible. Therefore patients have to know that if against use of means constant nausea, feeling of fatigue is shown, jaundice, pain in right hypochondrium, urine darkening, etc., it is necessary to address the specialist and to conduct examination of a liver.

It is not recommended to accept Lamizil to people with renal failures.

Side effects

Patients generally well transfer Lamizil, side effects are, as a rule, expressed poorly or moderately and are passing. Negative manifestations can be the following:

  • Hemopoiesis: seldom or never — an agranulocytosis, a neutropenia, a pancytopenia, thrombocytopenia.
  • Immune system: seldom or never — a lupus erythematosus, anaphylactoid reactions.
  • Nervous system: a headache, disturbances of taste up to loss, in rare instances — paresthesias, dizziness, hypesthesias.
  • Gepatobiliarny system: in rare instances — gepatobiliarny dysfunction, a liver failure.
  • Digestion: deterioration in appetite, feeling of overflow of a stomach, nausea, dyspepsia, diarrhea, abdominal pain.
  • Reactions of skin: not heavy skin manifestations in the form of urticaria and rash, in rare instances — heavy skin reactions, an exacerbation of psoriasis, a hair loss.
  • Musculoskeletal system: mialgiya, arthralgia.
  • At use of spray allergic skin manifestations can develop.

Application instruction of Lamizil (Way and dosage)

Duration of use of all forms of means depends on weight of an illness and appointment of the doctor.

The instruction on Lamizil in tablets

As a rule, to adult patients about 250 mg of medicine are appointed once a day. To children of a tablet are appointed in a dose which depends on their weight. At body weight to 20 kg to the child appoint 62.5 mg a day. If the body weight of the patient makes from 20 to 40 kg, appoint 125 mg if the weight of the child is more than 40 kg, to it appoint 250 mg.

At a dermatomycosis of feet treatment, depending on a condition of the patient, lasts from 2 to 6 weeks. For patients with a dermatomycosis of shins, trunks, and also with skin candidiasis treatment lasts from 2 to 4 weeks. At mycosis of pilar part of the head it is recommended to carry out treatment within 4 weeks. Patients with an onychomycosis should accept means from 6 to 12 weeks.

Spray Lamizil, application instruction

Adult patients can apply spray 1 or 2 times a day, depending on appointment of the doctor. Before putting means, it is necessary to clear and dry those sites of skin which were struck with an illness. It is necessary to spray Lamizil in such quantity completely to humidify the struck places, and also to apply it on adjacent parts of integuments. As a rule, at a dermatomycosis, an intertrigo, an inguinal epidermophitia treatment continues for one week, at the same time spray is sprayed once a day. By the patient with multi-colored it is deprived appoint spray use 2 times a day for 1 week. To children this means is not appointed as there is no sufficient experience of use of medicine for children.

Cream Lamizil, application instruction

It is possible to apply ointment 1-2 times a day to treatment of adult patients and children after 12 flyings. Before drawing means it is necessary to clear very carefully skin and to dry it. Cream needs to be applied on affected areas of integuments, and also on places near them. It is put with a thin layer and rubbed slightly in skin. If it is necessary to cure an intertrigo, it is possible to cover places on which cream, is applied with a gauze. It is desirable to do it for the night. At a dermatomycosis of feet treatment lasts for 1 week, it is necessary to apply cream once a day. If means is appointed at cracks, a skin itch which develop owing to a fungus, treatment lasts two weeks, it is necessary to put means 1-2 times a day. Patients with candidiasis of skin need to use cream 1-2 times a day, treatment, depending on a condition of the patient, 1-2 weeks last. By the patient with multi-colored it is deprived it is necessary to carry out treatment for two weeks, applying ointment 1-2 times a day. If means from a fungus of foot and from other diseases is applied irregularly, then the risk of recurrence of an infection increases.


If drug was accepted orally in high doses (5 g and more), then at the patient owing to overdose the headache, nausea, pain in epigastric area, and also dizziness can develop. At overdose it is necessary to give to the patient absorbent carbon, to provide a gastric lavage, to carry out, if necessary, a symptomatic treatment.


Interaction of active agent of Lamizil with other drugs is noted.

Acceleration of plasma clearance of a terbinafin is noted under the influence of drugs — metabolism inductors, suppression – under the influence of P450 cytochrome inhibitors. If it is necessary to apply at the same time these means, it is necessary to adjust Lamizil's dosage.

Influence of Cimetidinum strengthens influence of a terbinafin, can also increase its concentration in plasma. The clearance of a terbinafin under the influence of Cimetidinum decreases by 33%.

Rifampicin lowers effect of a terbinafin or reduces concentration of this substance in plasma. Under the influence of Rifampicin the clearance of a terbinafin increases by 100%.

There are data on what terbinafin can increase concentration of caffeine in plasma or strengthen its action. The clearance of caffeine at introduction intravenously under the influence of a terbinafin decreases by 19%

The clearance of Desipramine at a concomitant use of a terbinafin decreases by 82%.

Terbinafin weakens influence of Cyclosporine and reduces its concentration in plasma. The clearance of Cyclosporine under the influence of a terbinafin increases by 15%.

Terms of sale

It is possible to get Lamizil in a drugstore according to the recipe.

Storage conditions

It is necessary to protect all forms of drug from influence of light, temperature of storage should not exceed 30 °C. It is impossible to freeze means.

Period of validity

Lamizil it is possible to store tablets and cream 5 years, spray – 3 years,

Special instructions

There are no data on impact of this medicine on ability to driving of motor transport or work with exact mechanisms. If against treatment dizziness is noted, it is necessary to refrain from the specified actions.

If at the patient big fungal infections are noted, it is desirable for it to use spray in a big bottle — 30 ml.

As a rule, clinical manifestations decrease in the first few days treatments. If therapy is carried out irregularly or it was interrupted, the infection can renew.

If in one week after an initiation of treatment of improvement does not come, it is necessary to see a doctor and to specify the diagnosis.

It is necessary to apply spray on skin if on it there is a damage as alcohol can provoke irritation carefully. It is necessary to watch that spray did not get into eyes. If it occurred, it is necessary to wash out eyes water at once. At irritation of skin it is necessary to see a doctor.

If allergic reactions develop, it is necessary to stop administration of drug.

Lamizil for nails is issued also in the form of a varnish, but the specialist has to appoint such varnish only.

Lamizil's analogs

There are cheaper analogs of cream and other forms of medicine Lamizil. Generally it is the Russian analogs of Lamizil. It is ointment, tablets, and also spray Termikon, and also drugs Terbinafin, Terbifin, Terbizil, Ekzifin, Terbiks, Binafin, etc. The price of analogs of Lamizil depends on packaging and on a form of production of drug.

Ekzoderil or Lamizil – what is better?

Ekzoderil – drug which is also used for the purpose of elimination of fungal infections. However its structure contains other active ingredient – naftifin. This drug it is destructive influences cellular structure of fungi and works in deep layers of a derma. What of drugs to prefer in a specific case, only the doctor defines.


  • Lamizil spray of 1% 30 ml flakonnovartis Farm
  • Lamizil of 250 mg No. 14 tabletkinovartis Farm
  • Lamizil cream of 1% 15 g tubanovartis Farm
  • Lamizil Dermgel of 1% 15 g tubanovartis Farm
  • Lamizil spray of 1% 15 ml flakonnovartis Farm

Drugstore of IFC

  • Lamizil spray of 1% 30 ml, Novartis Pharmafrantion
  • Lamizil spray of 1% 15 ml, Novartis Consumer Health/Novartisshveytsariya
  • Lamizil tbl 250 mg No. 14, Novartis Pharmashveytsariya
  • Lamizil cream of 1% 30 g, Novartis Consumer Health/Novartisshveytsariya
  • Lamizil Dermgel gel of 1% 15 g, Novartis Pharmashveytsariya
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  • Lamizil Uno solution for external use plenkoobrazny 1% in tubas on 4 grnovartis (Germany)
  • Lamizilnovartis Consumer Health (Switzerland)
  • Lamizilnovartis Pharma (France)
  • Lamizil dermgelnovartis Consumer Health (Switzerland)
  • Lamizilnovartis Pharmaceuticals (Great Britain)


  • Lamizil aer. 1% 30mlnovartis Konsyyumer
  • Lamizil aer. 1% 30mlnovartis Konsyyumer
  • Lamizil aer. 1% 30mlnovartis Konsyyumer
  • Lamizil aer. 1% 30mlnovartis Konsyyumer
  • Lamizil aer. 1% 30mlnovartis Konsyyumer


  • Lamizil Dermgel of 1% 15 g gel in a tuba
  • Ламизил® Uno of 1% 4 g solution nar.plenkoobr.v to a tuba
  • Lamizil of 1% 15 g cream in a tuba
  • Lamizil of 1% 15 ml spray naruzhn.
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Section: Dermatological Antifungal
in more detail

Education: "Pharmacy" graduated from the Rovno state basic medical college majoring in. Graduated from the Vinnytsia state medical university of M. I. Pirogov and internship on its base.

Experience: From 2003 to 2013 – worked at positions of the pharmacist and manager of a pharmaceutical booth. It is awarded by diplomas and distinctions for long-term and honest work. Articles on medical subject were published in local editions (newspaper) and on various Internet portals.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Lamizil surely consult with the attending physician.