Латран Drug photo

The description is actual on 28.04.2015

  • Latin name: Latranum
  • ATH code: A04AA01
  • Active ingredient: Ondansetron (Ondansetron)
  • Producer: Farmzashchit's NPTS, Russia


One tablet Latran contains a dihydrate of an ondansetron of a hydrochloride – 4 mg + microcrystallic cellulose, potato starch, hydroxypropyl cellulose, tropeolin Oh, colloid silicon dioxide, magnesium stearate, the twin 80, castor oil.

In structure of one ml of means in the form of solution for infusions 2 mg of an ondansetron of a hydrochloride of a dihydrate + the water purified sodium chloride, hydrochloric acid descend.

Release form

Drug is let out in the form of yellow, coated tablets, in blister strip packagings on 10 pieces. In cardboard packs of 10 tablets. Also medicine is on sale in glass jars on 8000 or 4000 tablets.

Means is let out in the form of colourless, transparent liquid for intravenous or intramuscular pricks, in ampoules, with a capacity of 2 or 4 ml. In a cardboard pack of 1, 2 or 5 ampoules.

Pharmacological action

Antiemetic, antiabstinenty.

Pharmacodynamics and pharmacokinetics

Active ingredient of drug Latran is the selection antagonist of serotoninovy 5-HT3 receptors. Means possesses ability to slow down reaction of influence of specific factors to receptors and neurons, peripheral and central nanosecond. Drug does not render sedation, does not break coordination of movements, does not reduce activity of the patient. Medicine is capable to suppress process of manifestation of somatic and psychopathological symptoms of alcoholic abstinence.

After reception of tablets the effect is shown in 1,5 hours. At intramuscular introduction the maximum concentration in plasma is reached within 10 minutes. Process of distribution of active component does not depend on a way of introduction. Biological availability – about 60%. About 75% of means contact proteins of a blood plasma.

Medicine undergoes reactions of a metabolism in a liver. The elimination half-life – 3 hours, is removed mainly in the form of metabolites, the small part – in the form of not changed active ingredient is removed through kidneys. Elderly patients have a change of pharmacokinetic indicators: the elimination half-life is extended till 5 o'clock. At serious diseases of kidneys and a liver – to 4 till 30 o'clock, the truth of clinical value has no it.

Indications to use

Latran appoint:

  • at nausea and vomiting after chemotherapy, radiotheraphy, the roentgenotherapy caused by antineoplastic means;
  • as prevention of undesirable side reactions of an organism during the postoperative period;
  • after impact on a human body of ionizing radiation for the prevention of vomiting and severe nausea;
  • for a symptomatic treatment of alcoholic abstinence (average and easy severity).


Drug is not recommended to reception at pregnancy, during a lactation, to children till 2 flyings, in the presence of an allergy to its components.

Side effects

Usually medicine is transferred well.

As side reactions were observed:

Application instruction of Latran (way and dosage)

Medicine depending on a form of release is entered intravenously, intramusculary or orally inside.

For treatment of alcoholic abstinence enter 8 mg of medicine intravenously divorced in 400 mg physical. solution, Haemodesum or hlosolya. The drug can be administered repeatedly.

The application instruction of Latran at cytostatic therapy

Adult usually appoint from 8 to 32 mg of drug.

At moderate radiation it is shown:

  • intravenous or intramuscular administration of 8 mg of drug before an initiation of treatment;
  • reception of two tablets (8 mg) in 2 hours before therapy and 2 more tablets in 12 hours later.

In case of vysokoemetogenny chemotherapy appoint 8 mg intravenously before therapy and two more injections on 8 mg every 3 hour. Or daily infusion on 1 mg an hour. It is also possible to make 15-minute infusion by Latran's solution (16 mg on 100 ml physical. solution) directly before chemotherapy.

If before an initiation of treatment to enter intravenously a glucocorticoid, then efficiency of drug increases.

Also about 4 tablets a day divided into 2 receptions of 5 days after radiation or chemotherapy to avoid the delayed vomiting are recommended to accept.

After operations

The adult appoint intravenously struyno 8 mg of means (in 16 mg, that is 4 tablets) in 60 minutes prior to operation. To children appoint 0,1 mg of medicine to body weight kg intravenously (the maximum dosage of 4 mg) before operation or after it.

At impact of the ionizing radiation accept 2 tablets for an hour before procedure or in an hour after it.

If the patient has serious violations in work of a liver, then the maximum daily dosage makes 8 mg.

It is possible to dissolve drug for injections: 5% glucose rum; 0,3% potassium chloride rum; 0,9% sodium chloride rum; mix of potassium chloride and sodium chloride 0,9% or mix of solution of glucose of 5% and solution of potassium chloride of 0,3%.


Medicine has no specific antidote. At overdose carry out symptomatic therapy.

It is impossible to apply an ipecacuanha.


Process of a metabolism of an ondansatron happens to participation of system of P450 cytochrome therefore at a combination to inductors and inhibitors of microsomal CYP2D6, CYP3A enzymes it is necessary to observe extra care. It means that it is better not to combine medicine with barbiturates, Karizoprodol, Griseofulvin, the Papaverine, Phenytoinum, Rifampicin, Carbamazepine, Glyutetimid, nitrous oxide, Phenylbutazone, Tolbutamidum, Allopyrinolum, MAO inhibitors, Cimetidinum, Diltiazem, Erythromycin, Valproatum of sodium, a ftorkhinolonama, Ketokonazol, Metronidazole, Propranolol, Quinidine, makrolidny antibiotics, chloramphenicol, estrogen, Disulfiramum, Valproic acid, Flukonazol, the Isoniazid, Lovastatin, Omeprazol, Verapamil.

Terms of sale

The recipe is necessary.

Storage conditions

It is necessary to store drug in original packaging, in the dark place, at a temperature not higher than 30 degrees.

Period of validity

3 years.

Special instructions

The probability of development of hypersensitivity reaction increases at the persons which earlier had an allergy on other antagonists of 5-HT3-receptors.

Solution for an injection needs to be prepared directly before introduction. At an urgent need it can be stored at 2-8 degrees within a day.

Patients need to observe extra care at administration of drug with impassability of intestines as medicine can cause a lock.

During a prick or infusion there is no need to protect solution from influence of a sunlight, it is stable within a day.


Coincidence on the ATH code of the 4th level:

Vero-Ondansetron, Zofran, Domiegang, Emetron, Osetron, Ondansetron, Ondatron, Emeset.


  • Latran of 4 mg No. 10 of a tabletkifarmzashchit of NPTs
  • Latran solution for injections of 0,2% 2 ml No. 5 of an ampulyfarmzashchit of NPTs
  • Latran solution for injections of 0,2% 4 ml No. 5 of an ampulyfarmzashchit of NPTs

Drugstore of IFC

  • Latran solution for in 0.2% of amp of 4 ml No. 5, Farmzashchita NPTS Fguprossiya
  • Latran tbl p / about 4 mg No. 10 *, Farmzashchita NPTS Fguprossiya
  • Latran solution for in 0.2% of amp of 2 ml No. 5, Farmzashchita NPTS Fguprossiya
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