Layfferon

Лайфферон Drug photo

The description is actual on 27.07.2016

  • Latin name: Lifferon
  • ATH code: L03AB05
  • Active ingredient: Interferon alpha 2b human recombinant (Interferon alfa-2b human recombinant)
  • Producer: Vektor-Medika (Russia)

Structure

In 1 ampoule of 1, 3 or 5 million ME interferon. Sodium chloride, sodium hydrophosphate, sodium of dihydrophosphate, dinatrium edetat, twin, oxyglutathione, nipagin, as excipients.

Release form

Lyophilisate in bottles of 1 million ME, 3 million ME and 5 million ME for solution preparation.

Solution in ampoules of 1 million ME, 3 million ME and 5 million ME.

Pharmacological action

Anti-virus, antineoplastic, immunomodulatory.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Drug is similar to human interferon alpha 2b. Represents the recombinant cleared protein synthesized by colibacillus which genome the genes of human leukocytes coding interferon synthesis are built in. Interferon alfa-2b is active concerning viral infections and to tumor growth factors.

Antiviral action is caused by interaction with membrane receptors and disturbance of products of virus RNA that as a result suppresses reproduction of viruses. At prolonged use of this drug, as well as other interferon, in blood there are antibodies to interferon therefore efficiency of treatment decreases.

Pharmacokinetics

Is exposed to biotransformation in a liver, it is removed in not changed look by kidneys.

Indications to use

Complex treatment:

  • acute viral hepatitis In (severe forms);
  • chronic hepatitis B, C at emergence of cirrhosis;
  • long course of hepatitis B and C;
  • meningoentsefalita virus and virus and bacterial (it is effective in the first 4 days) diseases;
  • viral conjunctivitis, keratitis, keratoconjunctivites, keratouveita;
  • multiple sclerosis;
  • kidney cancer, planocellular carcinoma cutaneum, malignant lymphoma of skin, myelosis, Kaposha's sarcoma, subleukemic myelosis.

At children:

  • juvenile papillomatosis of a throat (after operational removal of papillomas);
  • acute lymphoblastoid leukosis (at remission on 4-5 month after the termination of chemotherapy).

Contraindications

Side effects

  • fever, fatigue, temperature increase, indisposition, headache, grippopodobny syndrome (at intramuscular introduction);
  • hyperemia mucous eyes, a conjunctival infection, a chemosis (at topical administration in an eye); leukopenia, thrombocytopenia, increase of level of alaninetransferase.

At heavy side effects the dose decline or interruption of treatment is allowed.

Layfferon, application instruction (Way and dosage)

Drug is used intramusculary, subkonjyunktivalno or in the defeat center locally. Schemes and terms of treatment at different diseases differ. The matter is resolved by the doctor depending on disease severity. We bring some of them.

Acute hepatitis In — intramusculary on 1 million ME twice a day within 5 days, then 1 million ME a day 5 more days. Continuation of treatment for 2 weeks — on 1 million ME 2 times a week is possible.

Long acute and chronic active hepatitis B — on 1 million ME twice a week about two months, if necessary till 4-6 months. Sometimes conduct 1-2 monthly courses three times with an interval of 2 months.

Chronic active hepatitis C without cirrhosis — on 3 million ME three times a week. A course of treatment till 8 months. If the effect is absent treatment prolong till 1 year.

Chronic active hepatitises V and D  with the cirrhosis phenomena — on 500 thousand ME twice a week.

Acute lymphoblastoid leukosis — on 1 million ME weekly half a year. At the same time appoint chemotherapy.

Myelosis — on 3 million ME every day from 2,5 to 6 months.

Lymphoma and Kaposha's sarcoma — on 3 million ME daily 10 days against tsitostatik and glucocorticosteroids.

Virus meningoentsefalita — on 1 million ME 2 times a day in a complex with antiviral drugs.

Multiple sclerosis — on 1 million ME of 1 - 3 time a day (depending on a condition of the patient) within 10 days, then 1 million ME weekly 6 months.

Conjunctivitis and keratitis — on 2 drops of solution to 8 times a day. In process of improvement the number of instillations reduce up to 3 times.

Bazalnokletochny carcinoma cutaneum — enter perifokalno under the defeat center daily 10 days. Then carry out a cryolysis.

Overdose

Data on overdose are absent.

Interaction

This interferon reduces activity of R-450 cytochrome and changes a metabolism of Cimetidinum, curantyl, Phenytoinum, diazepam, theophylline, warfarin, propranolol. Strengthens myelotoxic, neurotoxic and cardiotoxic effect of other drugs. It is necessary to avoid co-administration with immunosuppressors and medicines, the oppressing TsNS. It is impossible to take alcohol during treatment.

Terms of sale

It is released according to the recipe.

Storage conditions

Temperature of storage and transportation of 2-8 °C.

Period of validity

2 years.

Layfferon's analogs

Altevir, Alfaron, Interferal, Intron And.

About Layfferona

In medical practice the different interferona received by method of genetic engineering are used. These drugs are used for treatment of viral infections and oncological diseases. One of them Layfferon who thanks to lack of human albumine in structure, has a low immunogenicity is better had and is safe. In responses Layfferon's use most often takes place at a chronic viral hepatitis With and a papillomavirus at which it is effective.

Responses concern side reactions. Some patients transfer rather easily, and some — refuse treatment. At high pyrogenic reaction (more than 39 °C) use of indometacin, a nurofen or paracetamol is recommended. It is better to do an injection before going to bed and at once to take an antipyretic medicine. Next day to drink more liquid. It is necessary to tell that all interferona are transferred with high temperature. If it does not rise higher than 37, it means that the patient has a weak immunity.

  • "… Me the gynecologist before a cryolysis appointed. After a prick of hour heat, and then an ache the whole day was obese two".
  • "… At a viral hepatitis with appointed Layfferon (3 million three times a week) and Ribavirin in tablets. I accept 1,5 months. ALT and nuclear heating plant were normalized. Side reactions went — leukocytes fell. Lowered doses of drugs twice".
  • "… I give Layfferon's injections — side effects as at flu: temperature increase to 39, nausea and an ache in a body".
  • "… After the fifth prick the Ambulance as there was an allergic reaction took away me".
  • "… It is found pappilomavirus. After the first time temperature to 39, the head hurt awfully. Then temperature did not rise, but there was an ache, a headache, lymph nodes hurt".
  • "… Health after drug not really. After the first pricks — small weakness and temperature, and after the 8th prick rose to 38 degrees".

Zdravzona

  • Layfferon solution of 3 million ME No. 5 ampulyvektor of closed joint stock company
  • Layfferon solution of 1 million ME No. 5 ampulyvektor of closed joint stock company
  • Layfferon lyophilisate for solution of 3 million ME No. 5 an ampulyvektor of closed joint stock company
  • Layfferon lyophilisate for solution of 1 million ME No. 5 an ampulyvektor of closed joint stock company
  • Layfferon lyophilisate for solution of 5 million ME No. 5 an ampulyvektor of closed joint stock company
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Section: Immunity increase Antiviral Antineoplastic
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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