Ледибон Drug photo

The description is actual on 11.07.2016

  • Latin name: Ladybon
  • ATH code: G03CX01
  • Active ingredient: Tibolon (Tibolone)
  • Producer: "ZENTIVA FARMA" (Slovak Republic)


Tibolon, the micronized monohydrate of lactose, potato starch, lactose of direct pressing, offended palmitate, magnesium stearate.

Release form

Tablets round white color, flat in a blister strip packaging in cardboard a crustacean No. 28, 84.

Pharmacological action


Pharmacodynamics and pharmacokinetics


Drug belongs to group of anabolic steroids. Estrogen-gestagennym and poorly expressed androgenic action possesses. After fading of function of ovaries normalizes gipotalamo-pituitary system, reduces production of gonadotropic hormones. In the period of a postmenopause slows down process of a resorption of a bone tissue, softens or stops symptomatology of a menopausal syndrome (headaches, rushes of blood to the person, the strengthened sweating).

Positively influences mood and a libido, stimulates mucous vaginas, without causing at the same time proliferation of an endometria. Suppresses an ovulation at women of fertile age. Reduces concentration in blood serum of ions of phosphates and calcium, prevents osteoporosis.


Drug is quickly soaked up from a gastrointestinal tract. Consumption of food on absorbability of influence. Tibolon's concentration in blood low because of fast process of a metabolism, cumulation is absent. It is metabolized to pharmacological active metabolites. It is brought out of an organism with a stake and it is insignificant with urine in the form of the sulphated metabolites.

Indications to use

Completion of deficit of estrogen in a postmenopause. Prevention of development of osteoporosis and fractures of bones in the period of a postmenopause at contraindications of reception of other HP appointed for prevention of osteoporosis.


High sensitivity to drug, existence or suspicion on hormonedependent tumors, the expressed abnormal liver functions, cerebrovascular frustration, an endometria hyperplasia in the anamnesis, a thrombembolia, thrombophlebitis, vaginal bleedings of the obscure etiology, the period till one year after date of the last periods, the breastfeeding period, pregnancy.

To take drug with caution at migraine, endometriosis, a hypercholesterolemia, an endometria hyperplasia, a leiomyoma, a renal failure, bronchial asthma, epilepsy, disturbances of carbohydrate metabolism, a system lupus erythematosus.

Side effects

Dizziness, depression, migraine, diarrhea, change of body weight, hypostases, seborrheal dermatitis, hypertrichosis, metrorrhagia, hemorrhagic rash, itch, proliferation of an endometria, dorsodynia, extremities, vaginal bleedings, thrombosis of the lower extremities, arthralgia.

Ledibon, application instruction (Way and dosage)

Before therapy it is necessary to exclude malignancies of reproductive organs, especially in the presence of bloody allocations.

Regulations of Admission Ledibon: to begin to take a pill follows from an upper number of packaging, that tablet which is marked by the corresponding day of the week, and then, according to a day of the week before the end of packaging.

It is daily desirable to accept drug in at one time in a dosage 1 tablet a day. To swallow a tablet entirely, if necessary — to wash down with water. Dose adjustment is not required to elderly patients. Drug should be accepted not earlier than a year after date of the last natural periods. At non-compliance with this condition the risk of emergence of irregular bloody vaginal bleedings or allocations increases. After a surgical menopause treatment by drug should be begun immediately. It is desirable to begin treatment of postclimacteric symptomatology with the smallest effective dose. The minimum course of reception Ledibon — 3 months.

Transition on tibolon — reception Ledibon should be begun with the cyclic mode of use of ZGT of drug right after the termination of the previous scheme of treatment (next day), and upon transition from the continuous mode of treatment by the drugs combined by ZGT reception Ledibon can be begun in any day.

In a case when reception of a tablet is missed if the time interval does not exceed 12 hours, the passed dose of drug needs to be accepted whenever possible rather. If the time interval exceeds 12 hours, this reception needs to be missed, and to accept the following dose in usual time. At the same time, at frequent admissions of administration of drug the risk of emergence of vaginal bloody allocations increases.

Ledibon is not a contraceptive.


At administration of drug in the dose which is repeatedly exceeding a therapeutic dose nausea, vomiting, vulval bleeding can develop.


Drug strengthens effect of anticoagulants as increases fibrinolitic properties of blood.

Terms of sale

Prescription sale.

Storage conditions

At a temperature up to 25 °C.

Period of validity

2 years.


Coincidence on the ATH code of the 4th level:

Lindinet, Livial, Mersilon, Femoden, Evista, Femoston, Évian, Trisekvens, Kliogest.

About Ledibon

Comments of women and doctors on Ledibona generally positive:

"… Here nearly three years I take a pill Ledibon. Now on a quarter of a tablet in day. For me it is enough this dose. Any problems, I feel well. It is very happy".


  • Ledibon 2,5mg No. 28kh3zentiva
  • Ledibon 2,5mg No. 28zentiva

Drugstore of IFC

  • Ledibon of table 2,5mg No. 84, Zentiva A.Schekhiya
  • Ledibon of table 2,5mg No. 28, Zentiva A.Schekhiya
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  • Ledibon of 2,5 mg No. 28 of the tab. Zentiva of ampere-second. (Czech Republic)
to show still
Section: Gynecologic Hormonal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Ledibon surely consult with the attending physician.