Levofloxacin

Левофлоксацин Drug photo

The description is actual on 26.12.2014

  • Latin name: Levofloxacin
  • ATH code: J01MA12
  • Active ingredient: Levofloxacin (Levofloxacin)
  • Producer: Belmedpreparata of RUP (Republic of Belarus), Synthesis of joint stock company, Dalkhimfarm, Active component, MAKIZ-PHARMA, Krasfarm, VERTEXUM, Ozone of Ltd company (Russia), VMG Pharmaceuticals Pvt. Ltd. (India), Zhejiang Apeloa Pharmaceutical Co. (China)

Structure

Active agent of medicine – levofloxacin. Eye drops and solution for internal introduction contain the following auxiliary components:

  • sodium chlorine;
  • the deionized water;
  • dinatrium edetat dihydrate.

Tablets have the following additional components:

  • MKTS;
  • primelloza;
  • macrogoal;
  • iron oxide yellow;
  • gipromelloza;
  • calcium stearate;
  • titanium dioxide.

Release form

Form of release of medicine:

  • yellow, round and biconvex tablets in a film cover;
  • eye drops;
  • solution for internal introduction.

Also such drug synonym as Levofloxacin of Tev which is issued in tablets is known and differs on structure of excipients a little.

Pharmacological action

Drug represents antimicrobic medicine.

Pharmacodynamics and pharmacokinetics

Medicine is an antibiotic. Treats group of ftorkhinolon. Active component of drug possesses bactericidal properties. It is explained by inhibition of enzymes which are responsible for DNA replication in cells of bacteria.

This means is active in relation to the majority of causative agents of a bacterial respiratory infection. Effectively in treatment of the infections provoked by penitsillinrezistentny strains of a pneumococcus, Enterobacter spp., Escherichia coli, Klebsiella spp., Citobacter spp.

Levofloxacin is efficient at sinusitis and tuberculosis.

At reception on an empty stomach its bioavailability makes about 100%. If the dosage in 500 mg is accepted during meal, the maximum plasma concentration is reached on an hour later.

Medicine is distributed in intersticial liquid and plasma, and also to a large extent accumulates in fabrics. Only 5% of drug are split. Kidneys remove up to 85%. Semi-removal time – 6-7 hours. But post-antibiotic action remains by 2-3 times longer.

Indications to use

Drug in the form of tablets is used at infectious and inflammatory diseases which are provoked by sensitive microorganisms:

  • intraabdominal infection;
  • acute sinusitis;
  • uncomplicated infections of urinary tract;
  • exacerbation of chronic bronchitis;
  • prostatitis;
  • community-acquired pneumonia;
  • infections of integuments and soft tissues;
  • the complicated infections of urinary tract;
  • septicaemia or bacteremia.

Solution to internal introduction is applied at infections of lower parts of respiratory and urinary tract, kidneys, skin and soft tissues, ENT organs, generative organs.

Drops eye Levofloxacin are appointed at superficial infections of eyes of a bacterial origin.

Contraindications

This medicine has the following contraindications:

With caution the antibiotic Levofloxacin should be taken to people of advanced age, and also those at whom shortage glyukozo-6-fosfatdegidrogenazy is revealed.

Side effects

Undesirable side reactions at reception of this means are quite numerous. They can develop from various bodies and systems.

It is most often reported about diarrhea, increase of activity of liver enzymes and sick which are made by administration of drug.

Besides, the itch, appetite loss, vomiting, a headache, catalepsy, sleeplessness, decrease in quantity of leukocytes in blood, erubescence, problems with digestion, painful feelings in a stomach, dizziness, drowsiness, increase of maintenance of eosinophils in blood, the general feeling of weakness are possible.

It is in rare instances reported about anaphylactic reactions, a strong bronchospasm, aggravation of porphyrias, trembling of a body, hallucinations, superexcitation, confusion of consciousness, pressure decrease, muscle pains, increase in level of bilirubin and creatinine in blood, decrease in quantity of thrombocytes in blood, the small tortoiseshell, blood allocations at diarrhea, the increased concern, paresthesia on hands, a depression, spasms, a heart consciousness, a tendinitis, joint pains, reduction of number of neutrophils in blood, strengthening of bleeding.

In extremely exceptional cases emergence of hypostases on a face and a throat, blisters on skin, shock is probable. Vision disorders, taste and function of kidneys are possible, decline in the ability to distinguish smells and tactile sensitivity, a rupture of sinews, reduction of number of all blood cells, forming of steady infections, sharp pressure decrease, and also the level of glucose and quantity of basophiles in blood. Besides, hypersensitivity to influence of sunshine and an ultraviolet, a pneumonitis, a mnogoformny exudative erythema, a vascular collapse, muscular weakness, hemolitic anemia, fever, a vasculitis, a Lyell's disease, rabdomioliz, intersticial nephrite can develop.

In addition to the listed side reactions Levofloxacin as an antibiotic, can cause dysbacteriosis, and also lead to the increased reproduction of fungi. Therefore at its use it is also desirable to take antifungal medicine and means which contain bacteria for intestinal microflora normalization.

Eye drops Levofloxacin can provoke the following undesirable side reactions:

  • education mucous tyazhy in the eyes;
  • burning in eyes;
  • hemoz conjunctivas;
  • hypostasis of a century;
  • itch in an eye;
  • reddening of a conjunctiva;
  • erythema on centuries;
  • contact dermatitis;
  • headache;
  • allergy;
  • decrease in visual acuity;
  • blepharitis;
  • growths of nipples on a conjunctiva;
  • irritation of eyes;
  • photophobia;
  • rhinitis.

Application instruction of Levofloksatsin (Way and dosage)

For those who take the pill Levofloxacin the application instruction reports that medicine is intended for the peroral use 1-2 times/days. At the same time tablets cannot be chewed, they need to be washed down with water (about 1 glass). It is possible to accept to or during meals. Exact dosages depend on character and disease severity.

The following scheme of reception is shown to people with normal or moderately reduced function of kidneys:

  • the exacerbation of chronic bronchitis – is appointed by 250/500 mg for reception of times a day, therapy lasts 7-10 days;
  • sinusitis – is appointed by 500 mg for reception of times a day, therapy lasts 10-14 days;
  • uncomplicated infection of urinary tract – appoint 250 mg for reception of times a day, therapy lasts 3 days;
  • community-acquired pneumonia – appoint 500 mg for reception 1-2 times a day, therapy lasts 1-2 weeks;
  • the complicated infection of urinary tract – appoint 250 mg for reception of times a day, therapy lasts 7-10 days;
  • prostatitis – is appointed by 500 mg of times for reception of times a day, therapy lasts 4 weeks;
  • infections of skin and soft tissues – appoint 250 mg for reception of times a day or 500 mg for reception 1-2 times a day, therapy in both cases lasts 1-2 weeks;
  • intraabdominal infection – appoint 250/500 mg for reception of times a day, therapy lasts 1-2 weeks (in combination with antibacterial agents which exert impact on anaerobic flora);
  • the septicaemia, bacteremia – appoint 250/500 mg for reception of times a day, therapy lasts 1-2 weeks.

The instruction on Levofloxacin in the form of solution for internal introduction reports that it is necessary to use drug 1-2 time/day. Medicine is entered kapelno. If necessary solution can be replaced with tablets.

The course of use should not exceed 14 days. It is recommended to carry out therapy throughout an illness and two more days all the time after temperature becomes normal. A usual dosage which is indicated by the instruction Levofloxacin, – 500 mg. The exact scheme of reception and desirable duration of treatment are defined individually depending on a disease:

  • acute sinusitis – medicine is taken once a day by 10-14 days;
  • pneumonia, sepsis – medicine is taken by 1-2 times a day 7-14 days;
  • acute pyelonephritis – medicine is taken once a day by 3-10 days;
  • infection of integuments – medicine is taken by 2 times a day 7-14 days;
  • tuberculosis – medicine is taken by 1-2 times a day 3 months;
  • exacerbation of chronic bronchitis – medicine is taken once a day by 7-10 days;
  • prostatitis – medicine is taken once a day by 14 days, then it is necessary to pass to use of tablets in a dosage 500 mg according to the same scheme;
  • infection of zhelchevyvodyashchy ways – medicine is taken once a day;
  • malignant anthrax – medicine is taken once a day. After the condition of the patient is stabilized, it is necessary to pass to use of the tableted drug form according to the same scheme of 8 more weeks;
  • belly infection – medicine is taken once a day by 7-14 days.

At any disease after normalization of a state it is possible to pass to Levofloksatsin's reception in the form of tablets according to the same scheme before the termination of a course.

Therapy by this medicine cannot be stopped in advance, and also to intentionally miss reception. If the tablet or infusion after all were passed, it is necessary to accept immediately the necessary dosage, and then to continue treatment as before.

The scheme of use is necessary for people with heavy renal failures with clearance of creatinine to 50 ml/min. Depending on the clearance of creatinine (CC) the scheme of treatment can be following:

  • KK of 20 ml/min. – 50 ml/min. – at the beginning of therapy accept 250/500 mg then the patient has to receive a half from primary dosage, i.e. 125/250 mg every day.
  • KK of 10 ml/min. – 19 ml/min. – at the beginning of therapy accept 250/500 mg then the patient has to receive a half from primary dosage, i.e. 125/250 mg of times in two days.

During therapy by this medicine it is desirable to avoid influence of sunshine and not to go to a sunbed.

In rare instances at patients the tendinitis can develop. At the slightest suspicion on an inflammation of sinews it is necessary to stop drug intake and to begin treatment of a tendinitis.

Besides, drug can provoke hemolysiserythrocytes in case of shortage glyukozo-6-fosfatdegidrogenazy. So this category of patients should give medicine with care, watching the level of bilirubin and hemoglobin.

Drug exerts a negative impact on the speed of psychomotor reactions and ability to concentrate attention therefore at its use it is desirable to refuse the work demanding careful concentration of attention and fast reactions. Also driving of cars and service of mechanisms belongs to these types of activity.

Drops eye are dug in in a conjunctival sac in a dosage 1-2 drops in one or both eyes. It is necessary to do it each 2 hours (to eight times during the day) for the first two days of treatment. After that 3-7 more days it is necessary to use medicine each 4 hours (to 4 times during the day). In general, the course is expected 5-7 days.

If it is necessary to apply in addition other drugs to eyes, it is necessary to observe a break between instillations 15 minutes.

During instillations it is necessary to try to avoid a dropper tip touch by centuries and fabrics near eyes.

Overdose

At overdose by drug undesirable reactions from a nervous system are most probable: attacks of spasms, dizziness, confusion of consciousness and other. In addition, disorders of work of a gastrointestinal tract, lengthening of an interval of Q-T, erosive defeats of mucous can be shown.

Therapy is symptomatic. The dialysis is not effective, and the specific antidote does not exist.

Overdose by Levofloksatsin in the form of drops for eyes is improbable. The irritation of fabrics is possible: burning, hypostasis, dacryagogue, reddening, gripes in eyes. At emergence of these symptoms of an eye it is necessary to wash out clear water of room temperature. And if side reactions have the expressed character, it is necessary to address the specialist.

Interaction

Efficiency of medicine considerably decreases at a combination to Sukralfat, and also to antiacid drugs which contain aluminum, magnesium and salts of iron. Thus, between receptions of these means there has to be an interval, at least, two hours.

And in need of simultaneous use with antagonists of vitamin K it is necessary to control coagulant system of blood.

Cimetidinum and Probenitsid somewhat slow down removal of active agent of Levofloksatsin. So it is desirable to carry out therapy at such combination of means with care.

In insignificant degree drug also increases Cyclosporine semi-removal time. And the combination to glucocorticosteroids increases probability of a rupture of sinews.

At interaction with NPVS and Theophylline convulsive readiness increases.

Levofloxacin for infusions is combined with the following solutions for internal introduction:

  • Ringer's solution with a dextrose (concentration of 2,5%);
  • dextrose solution (concentration of 2,5%);
  • normal saline solution;
  • solutions for parenteral food.

It is forbidden to mix medicine with solution of heparin or sodium bicarbonate.

Clinically significant medicinal interactions of eye drops with other means are improbable.

Terms of sale

Is on sale according to the recipe.

Storage conditions

It is necessary to hold medicine in unavailable to small children and the dry place protected from penetration of sunshine. Optimum temperature – to 25 °C.

Period of validity

It is necessary to store drug in any form of release at most 2 years. The bottle with eye drops after opening is suitable for use for 30 days. It is impossible to use medicine on expiry date.

Levofloksatsin's analogs

Levofloksatsin's analogs – medicines which have as the operating component other antibiotic similar on antibacterial activity. For eye drops the following drugs are such:

Levofloksatsin's analogs in the form of tablets and solution for internal introduction the following:

  • tablets – Zarkvin, Ksenakvin, Lomatsin, Lomfloks, Nolicin, Norilet, Norfatsin, Oflotsid, Oflotsid forte, Sparflo, Tariferid, the Factive, Tsipreks, Tsiprodoks, Tsipropan, Ekotsifol, Gatispan, Lokson-400, Lomefloksatsin, Lofoks, Moksimak, Norbaktin, Normaks, Norfloxacin, Ofloks, Oflomak, Pleviloks, Sparbakt, Taritsin, Tseprova, Tsipraz, Tsifloksinal;
  • tablets and solution for internal introduction – Abaktal, Dzheofloks, Ifitsipro, Oflo, Ofloksin, Pefloksatsin, Protsipro, Tsiploks, Tsiprobay, Tsiprolet, Ciprofloxacin, Tsifran, Aveloks, Zanotsin, Zofloks, Kvintor, Ofloxacin, Tarivid, Tsiprobid, Yunikpef;
  • solution for internal introduction – Basidzhen, Ofloksabol, Tsiprolaker, Tsipronat, Tsiprofloksabol, Tsifratsid;
  • solution and powder for internal introduction – Pefloksabol;
  • tablets, solution and concentrate for internal introduction – Tsiprinol.

All specified drugs have the features and the scheme of use. You should not use them without appointment of the doctor. The price of analogs also strongly differs. One of the cheapest Ciprofloxacin, and one of the most expensive – Aveloks is considered.

Levofloxacin and alcohol

During therapy by drug it is necessary to refuse alcoholic drinks. Levofloxacin and alcohol are not compatible. Medicine aggravates its action on TsNS, thus, intoxication will be stronger, than usually. Strengthening of dizziness, confusion of consciousness, disturbance of concentration and speed of response, nausea is possible.

Zdravzona

  • Levofloxacin 5mgml 100 of ml No. 12 fl.
  • Levofloxacin 5mgml solution for infusions of 100 ml No. 1 of a flakonkrasfarm of joint stock company
  • Levofloxacin STADA 500 of mg No. 5 of a tablet
  • Levofloxacin 250 of mg No. 10 tabletkiverteks closed joint stock company
  • Levofloxacin 500 of mg No. 5 tabletkiverteks closed joint stock company

Drugstore of IFC

  • Levofloxacin tbl p/pl/o 500 mg No. 5, Zaorossiya's Vertexum
  • Levofloxacin tbl p/pl/o 500 mg No. 10, Zaorossiya's Vertexum
to show still

Apteka24

  • Levofloxacin
  • Tablet levofloxacin coated 500 mg No. 10 Health (Ukraine, Kharkiv)
  • Tablet levofloxacin coated 250 mg No. 10 Health (Ukraine, Kharkiv)
Section: Antibiotics Antimicrobic
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Levofloxacin surely consult with the attending physician.