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As a part of 1 capsule active agent of a sibutramin of a hydrochloride monohydrate in number of 10 or 15 mg, and also auxiliary components contains: microcrystallic cellulose, monohydrate of lactose, magnesium stearate, silicon dioxides and titan, iron oxide, gelatin, dyes.
Is issued in capsules.
Drug of a lindaks is included into group of the anorectics having the central effect.
Pharmacodynamics and pharmacokinetics
Substance sibutramin blocks the return serotonin reuptake and noradrenaline. The body weight of the patient decreases thanks to impact of this drug on the centers which are responsible for food saturation. Such influence happens in view of blockade of the return capture of substances noradrenaline and serotonin. At the same time Lindaksa does not block the return capture of MAO and has no affinity to the main receptors.
Biotransformation of a sibutramin occurs in a liver, at the same time active metabolites are formed. The greatest concentration of drug in a blood plasma occurs in 1-1.5 hours, after a single dose, 3 hours later for active metabolites. The metabolism of HP is not influenced by age, sex, the patient's weight.
Indications to use
Drug of a lindaks is appointed to patients with alimentary obesity at whom the index of body weight exceeds 30 kg/sq.m. It is applied at alimentary obesity with IMT of 27 kg/sq.m and more which is combined by a non-insulin-dependent diabetes mellitus or a dislipoproteinemiya.
Drug should not be used in the presence of the following diseases: the organic reasons of obesity, serious violations in food, mental diseases, a syndrome Gilles de la Turetta.
It is impossible to use drug at simultaneous treatment by MAO inhibitors or at their use for two weeks prior to reception of a meridi, reception of inhibitors of the return serotonin reuptake, hypnagogues, drugs which contain tryptophane, other HP for weight reduction of the central action.
This drug at diseases of cardiovascular system, a pheochromocytoma, uncontrollable arterial hypertension, a thyrotoxicosis, heavy disturbances in work of a liver, kidneys is contraindicated, to a benign hyperplasia of a prostate, closed-angle glaucoma.
Children, teenagers, people cannot appoint drug, 65 years are more senior, that at whom drug, alcohol, medicinal addiction, high sensitivity to a sibutramin is observed.
Carefully appoint HP at arrhythmias in the anamnesis, a cholelithiasis, chronic heart failure, arterial hypertension, neurologic disturbances, disturbances in functioning of a liver, kidneys easy and moderately severe, in the presence in the anamnesis of motor and verbal tics.
Side effects in the course of therapy can arise in the first three-four weeks of use of drug. Over time their intensity and frequency become less expressed.
In work of cardiovascular system tachycardia, increase of the ABP, a vazodilatation is shown (sometimes).
As a side effect high sweating can be shown.
Also isolated cases of manifestation of a dysmenorrhea, hypostases, grippopodobny syndrome, dorsodynia and in a stomach, a skin itch, increase of appetite, thirst, a depression, drowsiness, rhinitis, uneasiness, irritability, acute intersticial nephrite, bleedings, Shenleyna-Genokh's purpura, spasms, thrombocytopenia are described.
Lindaksa, application instruction (Way and dosage)
Drug the specialist has to establish a reception dose in an individual order. Reception drug is carried out in the morning, meal at the same time does not matter. The initial dose has to make 10 mg.
If the effect at the same time is not observed, that is the patient dumps less than 2 kg in four weeks, then the dose at good tolerance of means can be raised to 15 mg a day. In case of absence effective influence treatment should not be continued.
According to the instruction patients who could not lose weight during this time for 5% of initial level do not need to continue therapy after three-months administration of drug by that.
It is also not necessary to practice further treatment if after weight reduction against treatment to data of HP the patient gains more than 3 kg. Reception duration drug of a lindaks cannot proceed Bol two years, information on safety of administration of drug throughout longer time is absent.
The probability of strengthening of side effects increases.
At treatment of overdose apply therapy on symptoms, a gastric lavage, use of absorbent carbon. There is no specific antidote.
It is careful to use together with Ketokonazol, erythromycin, troleandomitsiny, cyclosporine.
Can lead joint use together with means to serious effects, increasing serotonin level.
Term between the end of reception of inhibitors of monoaminoxidase and the beginning of reception of this means has to make not less than two weeks.
Terms of sale
The recipe is required.
It is necessary to store drug of a lindaks at a temperature which is not exceeding 30 °C.
Period of validity
The period of validity of drug makes 2 years from a date of issue.
Drug is used in exceptional cases when all other attempts to reduce body weight were inefficient. Medicine only under control of the specialist doctor is used.
When using means control of arterial pressure and heart rate is required.
With care the medicine to people with epilepsy, a liver, renal failure is appointed.
Can influence management of a car, speed of physical and mental reactions.
Analogs of tablets it is possible to call drugs: Zeliks, Meridia, Waist.
Section: For weight loss
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