Линдинет Drug photo

The description is actual on 04.03.2015

  • Latin name: Lindynette
  • ATH code: G03AA10
  • Active ingredient: Ethinylestradiol + Gestoden (Ethinylestradiol + Gestodene)
  • Producer: Gedeon Richter (Hungary)


Lindinet's structure 20 (1 tablets):

  • ethinylestradiol – 0,02 mg;
  • gestoden – 0,075 mg;
  • calcium sodium edetat – 0,065 mg;
  • magnesium stearate – 0,2 mg;
  • colloid silicon dioxide – 0,275 mg;
  • povidone – 1,7 mg;
  • corn starch – 15,5 mg;
  • monohydrate of lactose – 37,165 mg.

Lindinet's structure 30 (1 tablets):

  • ethinylestradiol – 0,03 mg;
  • gestoden – 0,075 mg;
  • calcium sodium edetat – 0,065 mg;
  • magnesium stearate – 0,2 mg;
  • colloid silicon dioxide – 0,275 mg;
  • povidone – 1,7 mg;
  • corn starch – 15,5 mg;
  • monohydrate of lactose – 37,165 mg.

Both pharmaceutical forms are delivered in the form of tablets which cover has the following components:

  • sucrose – 19,66 mg;
  • calcium carbonate – 8,231 mg;
  • macrogoal of 6000 - 2,23 mg;
  • titanium dioxide – 0,46465 mg;
  • povidone – 0,171 mg;
  • yellow quinolinic dye (D + About yellow No. 10 – E 104) – 0,00135 mg.

Release form

In pharmaceutical booths medicine is presented in the form of round, biconvex tablets which are covered with a cover of light yellow color from two parties. Texts or designations are absent. On a break a tablet white or close to white colors with a light yellow fringing of a cover.

Pharmacological action

Lindinet is carried to group of the monophase combined peroral contraceptive medicines on the basis of sex hormones, it is respectively applied mainly for the purpose of contraception. The main therapeutic effect of drug is connected with several mechanisms of action including decrease in secretion of gonadotropic hormones of a hypophysis, active preventing to ovulatory processes and braking of maturing of follicles in ovaries at once.

First of all, it should be noted that ethinylestradiol, one of biological active components, is synthetic analog of follicular hormone of oestradiol which together with hormones of a yellow body participates in regulation of a menstrual cycle of the woman, considerably braking it at certain stages.

Other active component – gestoden represents a gestagenny derivative of a 19-nortestosteron and is the version of the natural progesterone, stronger and selection on the action, emitted by a yellow body. This component is used in ultra low quantities thanks to what does not implement the androgenic opportunities (a chemical basis for a gestoden the variation of male sex hormone is) and in the weakest measure influences a carbohydrate and lipidic metabolism of an organism.

In addition to the central mechanisms of action directly on sex hormones, medicine implements contraceptive properties indirectly through peripheral components. Under the influence of pharmaceutical drug the endometria susceptibility to a blastocyste decreases that makes almost impossible process of implantation of initial forms of a fruit. Also density and viscosity of the slime which is localized in a neck of uterus which becomes considerably impassable for the spermatozoa making the active movements towards a female ovum increases.

Lindinet renders not only contraceptive effects, pharmaceutical drug promotes active prevention of some gynecologic diseases and not only. In particular, the possibility of emergence of functional ovarian cysts and extrauterine pregnancies decreases. The risk of emergence of fibroadenomas in mammary glands decreases, congestive inflammatory processes of practical come to naught. Favorable properties of medicine extend also to integuments as their general state improves and extent of display of acne rash (at regular use dermatological defects vanish absolutely) decreases.

Pharmacodynamics and pharmacokinetics

Pharmacokinetic abilities of a gestoden

After oral administration quickly enough and almost completely the active component is soaked up from a digestive tract, its bioavailability makes about 99%, and the maximum concentration in 2-4 ng/ml is noted after 1 hour.

In a circulatory bed gestoden contacts albumine and the GSPG specific globulin, in a free look there are only 1-2% of quantity of the operating component. The pharmacokinetics of a gestoden considerably depends on the GSPG level and concentration of oestradiol, the quantity of the selection carrier increases by 3 times under the influence of a sex hormone. Continuous reception of oral contraceptives also promotes active saturation gestodeny, at its daily use concentration increases by 3-4 times.

The active component undergoes the main stages of biochemical transformation in a liver then only in the form of metabolites it is removed with urine (60%) and a stake (40%). The elimination half-life of the operating component two-phase also takes about 1 days as the average plasma clearance makes from 0,8 to 1 ml/one million/kg.

Pharmacokinetic abilities of ethinylestradiol

The second active component possesses a little lower indicators of absorption – because of presistemny conjugation and primary metabolism absolute bioavailability of a pharmacological component makes only 60% of a digestive tube, and the maximum concentration in 30-80 pg/ml is reached in 1-2 hours.

From distribution ethinylestradiol opposite wins against a gestoden, 98,5% of active ingredient contact nonspecific albumine. Also active component induces increase of the GSPG level that highly affects total efficiency of an oral contraceptive. The constant average level of ethinylestradiol is established by 3-4 day after the beginning of a therapeutic course, and it is 20% higher, than after a single dose of a tablet of Lindinet.

Biotransformation of active ingredient occurs in a liver and represents an aromatic hydroxylation with formation of metilirovanny and hydroxylated products of an exchange in a free look or in the form of conjugates with sulfates or glucuronides. The metabolic clearance from a blood plasma fluctuates in borders of 5-13 ml.

Ethinylestradiol only in the form of products of an exchange with urine and bile in the ratio 2:3 is removed. The elimination half-life, as well as at a gestoden, two-phase also makes about 1 days.

Indications to use

  • contraception;
  • functional disturbances of a menstrual cycle.


  • individual hypersensitivity to pharmaceutical drug or its making components;
  • risk factors of arterial or venous thrombosis;
  • arterial hypertension of average and heavy degree;
  • tranzitorny ischemic attack or stenocardia as thrombosis harbingers;
  • surgical intervention with a long immobilization;
  • diabetes mellitus;
  • pancreatitis with the expressed increase of triglycerides of blood;
  • dislipidemiya;
  • serious illness of a liver (hepatitis, cholestatic jaundice and dr);
  • cholelithiasis;
  • Gilbert's syndrome, Cudgel Johnson, Rotor;
  • the new growth localized in a liver;
  • otosclerosis or existence it in the anamnesis of the previous pregnancy or after reception of glucocorticosteroids;
  • smoking is aged more senior than 35 years;
  • hormonedependent malignant tumors of generative organs and mammary glands;
  • vaginal bleeding of the obscure origin;
  • period of a lactation and incubation of the child.

Side effects

The adverse effects of treatment demanding immediate cancellation of pharmaceutical therapy:

Side effects after which emergence expediency of further use of medicine is solved in an individual order:

  • From a reproductive system: acyclic bleedings from a vagina of not clear etiology, an amenorrhea, kolpotsitologichesky change of vulval slime, inflammatory diseases, vagina candidiasis, pain, increase in mammary glands, a galactorrhoea.
  • From the central nervous system: decrease in hearing, depression, migraines, lability of mood.
  • Dermatological reactions: nodal or exudative erythema, unclear rash, hloazma, strengthening of an alopecia.
  • From the alimentary system: pains in epigastriums, nausea and vomiting, an illness Krone, nonspecific ulcer colitis, jaundice and an itch which is caused by it, a cholelithiasis, liver adenoma, hepatitis.
  • From exchange processes: a liquid delay in an organism, decrease in tolerance to carbohydrates, increase of level of triglycerides or glucose of blood, increase in body weight.
  • Other allergic reactions.

Application instruction of Lindinet (Way and dosage)

Lindinet 20, application instruction

Contraceptive tablets are used orally inside once a day, without chewing and washing down with enough water regardless of meal. Whenever possible it is necessary to take a pill at the same time days within 21 days, further it is necessary to take a break within 7 days then to resume use of contraceptives. That is the following tablet needs to be used in 4 weeks from the moment of the beginning of a course of week on the same day. During a break uterine bleedings will be observed that corresponds to periods in a normal cycle.

It is necessary to begin a course of conservative contraception from 1st to the 5th day of a menstrual cycle if before other peroral contraceptive were not used. Otherwise, the 1st pill needs to be taken after reception of the last dose of the previous pharmaceutical drug containing hormones in the 1st day of bleeding after cancellation.

Transition from progestagenosoderzhashchy funds for Lindinet demands use of an additional way of contraception in the first week. Date of the first reception of new contraceptive has to be agreed with a pharmaceutical form of the previous drug:

  • in the form of mini-tablets – in any day of a menstrual cycle;
  • in case of injections – on the eve of the last prick;
  • implant – next day after its removal.

Lindinet 30, application instruction

As this pharmaceutical form represents the strengthened Lindinet's version 20 with bigger concentration of ethinylestradiol, it is recommended to appoint after carrying out abortion that recovery of a physiological hormonal background was much quicker and less painful.

If abortion was made in the 1st trimester of pregnancy, then there is nothing to worry. Reception of oral contraceptives can be begun right after carrying out gynecologic manipulation and need of use of additional methods of contraception is not present.

If abortion or childbirth happened in the 2nd trimester of pregnancy, then reception of pharmaceutical drug can be begun only for the 21-28th days after the performed obstetric operation. At later beginning of a course of conservative protection in the first week it is necessary to use a barrier method of contraception. If full sexual intercourse took place to be prior to medicine reception, then before reception contraceptive it is necessary to be convinced of lack of new pregnancy.

Admission of a tablet of an oral contraceptive

If the next reception of a tablet was missed, then the missing amount of pharmaceutical drug in a circulatory bed needs to be filled as soon as possible. At a delay which on duration does not exceed 12 hours clinical effects of a contraceptive do not decrease also need for additional protection in other ways of contraception by itself disappears. The subsequent pill is taken according to the usual mode.

If the woman passed a tablet and did not fill its loss within 12 hours, then pharmacological efficiency of drug decreases that demands special measures and precaution. First of all, in the shortest possible time it is necessary to resume administration of drug and further to carry out it in the usual mode. For a week after the admission it is recommended to use any other methods of contraception.

This situation can become complicated if in packaging with tablets there were less than 7 pieces. How to accept in that case – to begin the following pack without observance of a necessary week break which is carried out only on the end of the 2nd packaging with contraceptives. It should be noted that in a usage time of the 2nd pack even the breakthrough bleedings indirectly capable to point to pregnancy existence can be observed smearing or. If hemorrhages on the end of the 2nd packaging did not stop, then before continuing reception of contraceptive it is worth seeing a doctor and to exclude existence of the developing fruit in a womb.


Reception of excess quantity of a contraceptive is followed by the following symptoms:

  • nausea;
  • vomiting;
  • vulval bleeding in small amounts.

There is no specific pharmaceutical antidote for medicine therefore symptomatic therapy of separate clinical displays of intoxication is applied.


Contraceptive properties of pharmaceutical drug decrease at its use with such medicines as Ampicillin, Tetracycline, Rifampicin, barbiturates, Primidonum, Carbamazepine, Phenylbutazone, Phenytoinum, Griseofulvin, Topiramat, Okskarbazepin.

Therefore in need of sharing of these drugs with Lindinet it is necessary to apply additional non-hormonal contraceptives within 7 days (it is recommended to visit additional consultation at the attending physician and for certain to specify term). Emergence of the smearing or breaking through bleedings, disturbances of a menstrual cycle or some other side effects is also possible.

In the conditions of the raised vermicular movement or diarrhea the time spent of contraceptive drug in a digestive tract gleam decreases that considerably reduces absorbing properties of a hormonal contraceptive. Any medicine, shortening Lindinet's finding in a digestive tube leads to decrease in concentration of active components of components in blood, and respectively to reduction of their useful effect.

Medicinal interactions at a stage of absorption are modelled on the combined use of a contraceptive with ascorbic acid as biologically active agents equally are exposed to sulphation in an intestines wall that brakes metabolic chains and increases bioavailability of ethinylestradiol.

Terms of sale

Acquisition of medicine is authorized only according to the receptor form.

Storage conditions

It is necessary to preserve pharmaceutical drug in the dry, protected from direct sunshine place unavailable to children of younger age at the temperature condition which is not exceeding 25 degrees Celsius.

Period of validity

3 years

Special instructions

Pregnancy after use of hormonal contraceptives

Peroral hormonal contraceptives are a group of pharmaceutical drugs on the basis of synthetic analogs of female sex hormones (estrogen and progesterone) which interfere with approach of an ovulation, preventing a possibility of fertilization. Of course, the large audience of women is convinced that to use them for the purpose of contraception harmfully as normal, physiologic pregnancy after medicamentous change of a hormonal background most likely will not come. However it is one of myths about this group of medicines.

After the termination of reception of hormonal contraceptives and on the termination of a course of conservative contraception effects of drugs gradually come to naught. Feature consists only that when planning pregnancy it is necessary to learn exact terms of the optimum moment for fertilization in clinic for women or from the personal gynecologist. Every time taking a medicine from a headache the woman does not worry about health of yet not conceived child, in this case the situation is almost identical.

When it is possible not to be protected by barrier methods of contraception

Lindinet belongs to reliable hormonal contraceptive drug that can be learned from a special indicator of number of the pregnancies which came during passing of a course of peroral contraception at 100 women during 1 year. For this pharmaceutical means it makes only 0,05 if to use contraceptive correctly and only according to the scheme of use. However pharmacological effects of Lindinet develop not at once fully, and only by 14th day from the beginning of reception of tablets therefore in the first 2 weeks it is recommended to use barrier methods of contraception.

Lindinet 20 and Lindinet 30 — in what a difference?

A large number of visitors of pharmaceutical forums for women are set by the following number of questions: "Lindinet 20 and 30 — in what a difference?", and whether medicines also are interchangeable and, at last, – that it is better from two forms of contraceptive drug. Distinction of forms of the same contraceptive lies in concentration of one of active components – ethinylestradiol. In peroral tablets its level can make 0,02 mg and 0,03 mg respectively that in the biochemical plan really refers them to various categories.

Lindinet 20 has softer pharmacological effect and in a smaller measure promotes increase of the selection carrier of GSPG that allows to use it for the purpose of contraception, however therapeutic needs, as a rule, require stronger form of medicine therefore Lindinet 30 is used. In what more concentrated drug form differs from weaker tablets — is not advertized as sometimes according to individual indications even as contraceptive it is necessary to apply Lindinet 30 that can be apprehended by the woman as unfair loading hormonal drug.

To independently replace pharmaceutical forms of medicine categorically contraindicated, the qualified specialist who appoints contraceptive or therapeutic means relies on results of clinical trials, their treatment and long-term experience in the sphere, but not on approximate idea of the biomechanism of a female organism. At emergence of any side effects or other adverse effects it is necessary to address for consultation and to resolve the matter in an individual order.


Among similar Lindinet of pharmaceutical drugs should allocate several groups of contraceptives:

  • Lindinet's analogs 20 with the ATH identical code and structure of the operating components: Logest, Model of Oozes, Femoden;
  • analogs with coincidence of the ATH code of the 4th level: Angeleta, Vidor, Dayla, Naadin, Novinet.

Lindinet 20 or Logest — what is better?

As well as Lindinet, Logest treats group of the combined oral hormonal contraceptives. The same active components in identical quantities are a part of pharmaceutical drug, that is 1 tablet of contraceptive contains ethinylestradiol 0,02 mg and a gestoden of 0,075 mg. The only essential distinction of medicines is a country of origin, and respectively and a price indicator.

As Lindinet is made in Hungary, cost in pharmaceutical booths is far lower than it, than at the drug released joint forces of the French and German druggists however it does not speak at all about efficiency of the first therefore the choice of a contraceptive should be assigned to the qualified specialist, it is based on individual indicators of hormonal balance and some other medical aspects.

That it is better: Novinet or Lindinet 20?

Novinet – the monophase oral contraceptive which in addition to ethinylestradiol incorporates synthetic progestogen dezogestret that changes the mechanism of effect of contraceptive drug a little. As well as all artificial pharmaceutical components of this nature, dezogestret has high affinity to the progesteronovy receptors located in gipotalamo-pituitary area what its effects are based on. In rather small quantities it is capable "to include" a negative feedback mechanism what sharp braking of release and development of gonadotrophins and full blocking of an ovulation is result of.

As Novinet includes so strong pharmaceutical component as one of actively active ingredients, respectively and the price is almost twice higher than it, than at Lindinet's drug. However at certain individual indications or contraindications the woman has no opportunity to use cheaper contraceptive that allows to include in a conservative course of contraception of Novinet.


  • Lindinet of the 20th No. 21 tabletkigedeon Richter
  • Lindinet of the 20th No. 21х3 tabletkigedeon Richter
  • Lindinet of the 30th No. 21 tabletkigedeon Richter

Drugstore of IFC

  • Lindinet 20 tbl p / about No. 63, Gedeon Richtervengriya
  • Lindinet 30 tbl p / about No. 21, Gedeon Richtervengriya
  • Lindinet 20 tbl p / about No. 21, Gedeon Richtervengriya
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  • Lindinet of the 20th tablet coated No. 63 Gideon Richter (Hungary)
  • Lindinet of the 20th tablet coated No. 21 Gideon Richter (Hungary)
  • Lindinet of the 30th tablet coated No. 21 Gideon Richter (Hungary)


  • Lindinet of 20 tab. p / about No. 21 Gideon Richter
  • Lindinet of 20 tab. p / about No. 21 Gideon Richter
  • Lindinet of 20 tab. p / about No. 21 Gideon Richter
  • Lindinet of 20 tab. p / about No. 21 Gideon Richter
  • Lindinet of 20 tab. p / about No. 21 Gideon Richter


  • Lindinet of the 20th No. 21х3 of table.
  • Lindinet of the 20th No. 21 of table.
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Section: Gynecologic Contraceptives
in more detail

Education: Kharkiv national medical university

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use of Lindinet surely consult with the attending physician.